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2nd ASPIC International Congress, 28 - 29 April, Porto CONGRESS PROGRAMME THURSDAY, 28 APRIL 09.00 Opening Session Symposium II Symposium EARLY CANCER DETECTION TUMOUR IMMUNOLOGY Chairs: José António Dias Pereira,Demengeot Carla Oliveira Chairs: Dinis, Jocelyne 12.30 Paulo Rodrigues-Santos . Portugal PD-1 downregulation on Tregs during Tyrosine Kinase Inhibitor therapy in Chronic Myeloid Leukemia 13.00 Lunch 14.00 Poster Parallel Sessions Chairs: A.T. Maia, A. Preto, F. Carneiro, G. Sousa, I. Fonseca, M. Damasceno, M.J. Cardoso, M.J. Bento, N. Lunet, N. Sousa, R. Seruca, R. Henrique, S. Socorro 16.00 Coffee-break INVITED SPEAKERS 09.30 Bruno Silva Santos . Portugal Gamma-delta T lymphocytes in the tumour environment: from oncoimmunology to adoptive cell immunotherapy. 10.00 Jolanda de Vries . Netherlands Harnessing adaptive immune responses in hereditary cancer. SELECTED SPEAKERS 10.30 Célia Gomes . Portugal Natural Killer cell-based adoptive immunotherapy eradicates and promotes the differentiation of chemoresistant stem-like cells. 10.45 Karine Serre . Portugal Tumour-associated neutrophils inhibit pro-tumour IL17producing gamma-delta T cells. 11.00 Coffee-break Symposium Symposium IIII NEW RESEARCH APPROACHES FROM ASPIC –ASEICA IMMUNOMODULATION OF CANCER Chairs: Bruno Silva Santos, Júlio Oliveira INVITED SPEAKERS 11.30 Frederick Arce Vargas . United Kingdom Targeting immune regulation in the tumour site. 12.00 Jeffrey Weber . United States Efficacy and Biomarker Analyses of the Use of Checkpoint Inhibition in Melanoma. SELECTED SPEAKERS 12.30 Ana Catarina Pinho . Portugal Functional capacity of tumor lysate-pulsed monocytederived dendritic cells inducing in vitro immune responses Symposium III RADIATION BIOLOGY AND RADIOTHERAPY Chairs: Luísa Carvalho, Pedro Almeida INVITED SPEAKERS 16.30 Rolf Lewensohn . Sweden Molecular tumour response to accelerated ions and role of cellular modifying factors. 17.00 Marie Dutreix . France Focus on the combination of DNA repair inhibitors with radiotherapy. SELECTED SPEAKERS 17.30 Paula Boaventura . Portugal TERT promoter mutations in thyroid carcinoma from childhood irradiated tinea capitis patients. 17.45 Ana T. Pinto . Portugal Macrophages modulate colorectal cancer cell response to radiation. 18.00 19:00 ASPIC General Assembly 20.00 Congress Dinner 2nd ASPIC International Congress, 28 - 29 April, Porto FRIDAY, 29 APRIL Symposium III IV Symposium CANCER GENES: WHAT DID LEARN FROM THEM? SIGNALING PATHWAYS: THEWE ANDROGEN RECEPTOR MODELSergio Dias, João Nuno Moreira Chair: Chairs: Carmen Jerónimo, Nuno Sousa INVITED SPEAKERS 09.30 Wytske van Weerden . Netherlands The continued role of AR in castration-resistant prostate cancer. 10.00 Tiffany Traina . United States The role of the AR in advanced breast cancer. 13.00 Lunch MECHANISMS AND IMPLICATIONS OF TUMOUR PLENARY LECTURES HETEROGENEITY Chairs: Manuel Sobrinho Simões, Nuno Miranda, Jorge Soares, Carlos Camps ASPIC Lecture 14.00 Alberto Cambrosio . Canada Mapping the development of Portuguese clinical research in oncology. ASEICA Lecture SELECTED SPEAKERS 14.45 10.30 Cristina Amaral . Portugal Estrogen-dependent breast cancer: the involvement of androgen receptor in exemestane-acquired resistance. 10.45 Inês Graça . Portugal Androgen Receptor mediates castration-resistant prostate cancer cells response to the DNMT inhibitor Hydralazine. EACR Lecture 15.30 Coffee-break Richard Marais . United Kingdom RAS and RAF signalling in melanoma: from basic biology to clinical responses. 16.15 11.00 Luis Paz Ares . Spain Lung cancer precision treatment. Closing Session Research Trial / Pixels Brand Oral Presentation Prize EACR Poster Prizes Symposium V CELL AND TUMOUR BIOLOGY Chairs: Luís Costa, Fátima Baltazar INVITED SPEAKERS 11.30 Gunther Boysen . United Kingdom Molecular features of SPOP mutant/ CHD1 deleted prostate cancer. 12.00 Joan Seoane . Spain Tackling intratumour heterogeneity in brain tumors. SELECTED SPEAKERS 12.30 Joana Vieira de Castro . Portugal Autofluorescence as a new biomarker to identify Glioblastoma Stem Cells. 12.45 Ana Sofia Ribeiro . Portugal P-cadherin, a therapy predictive biomarker for Dasatinib in basal-like triple negative breast cancer. OLI Poster Prizes