Download Introduction to Genetics (Dorn)

BIO 343 INTRODUCTION TO GENETICS
LECTURER: Dr. Lisa Dorn
Fall 2007
OFFICE: HS 45; LAB: HS 47 PHONE: 424-3064; E-MAIL: [email protected]
OFFICE HRS: TBA (discuss this first day)
LECTURE HOURS: 1:50 – 2:50 am in Halsey Science Building; Rm. 260
TEXT: Brooker, Genetics: Analysis & Principles (2nd edition) McGraw Hill.
OBJECTIVES: Genetics and its experimental methods is one of the broadest and most
rapidly evolving fields of science. I cannot possibly cover it all, so my goal is to teach
you how to think like a geneticist, while learning genetics concepts so that you can judge
for yourself the value of emerging genetic technologies and discoveries. This course
covers Mendelian genetics and its complications, the molecular basis of genes and their
affect on phenotypes, the methods of identifying and characterizing the genetic basis of
diseases and other phenotypes as well as population and evolutionary genetics.
The prerequisites for this course are Bio105 and 323, which by extension means you have
taken Chem 105 and 106 as well as Bio111. The laboratory part of this course will
expand on what you have learned in Molecular and Cell Biology (Bio 323). I will
assume you have mastered the Bio323 material and will not waste much time reviewing
this material. However, there will be some review of 323 materials in lab.
ASSESSMENT: How are you going to earn your grade?
EXAMS: 4 exams each worth 100 points. They will be mostly problems similar
to those in your D2L quizzes. (400 total points).
PROBLEM SOLVING: There will be 10 D2L problem-solving sessions where
you will be required to solve problems that will be available on D2L. Worth 10 points
each (total = 100 points). These problems are presented as quizzes. The problems will
be available 1 week before they are due. During those days you are allowed to discuss
potential solutions with your peers and me but once you submit your answer you cannot
change it. You can only see the answers after you submit.
LABORATORY: Is worth 105 points. The lab syllabus is available separately.
Total Possible points = 605.
92 – 100% = A, 89-91% = AB, 82-88% = B, 79-81% = BC, 72 – 78% = C, 68 – 71% =
CD, 67 – 60% = D, below 60 = F.
The schedule of lectures, exams and due dates for problems. There may be minor
changes to this schedule without notice. I will announce such changes in class.
Lec
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1
Date
5-Sep
6-Sep
7-Sep
Topics
Mendels Laws; Monohybrids & Dihybrid Crosses
Book
Ch. 2
2
Day
Wed
Thursday
Friday
Dihybrid Crosses & Pedigrees
Ch. 2
Week
1
1
1
3
Monday
10-Sep
Pedigree Analysis; Probability Rules chi square Test
Ch. 2
2
4
Wed
12-Sep
Chromosomes; Meiosis & Mendel's rules
Ch. 3:
2
Thursday
13-Sep
Ch. 3:
2
5
Friday
14-Sep
Sex chromosomes; Sex-Linked Traits
6
Monday
17-Sep
Sex determination; recessive Lethals
Ch. 3/4
3
7
Wed
19-Sep
Pleiotropy; Incomplete Dominance; co-dominance
Ch. 4
3
Thursday
20-Sep
8
Friday
21-Sep
Gene dosage, Overdominance,
9
Monday
24-Sep
Penetrance, Expressivity, Complementation
Wed
26-Sep
EXAM 1 (covers up to lecture 9)
Thursday
27-Sep
10
Friday
28-Sep
Gene interactions,
Ch. 4
4
11
Monday
1-Oct
Linkage and Recombination;
Ch. 5
5
12
Wed
3-Oct
Mapping genes: dihybrid crosses
Ch. 5
5
13
Thursday
4-Oct
Friday
5-Oct
Trihybrid crosses
Ch. 5
5
14
Monday
8-Oct
Intragenic Mapping, bacteriophage
Ch. 6
6
15
Wed
10-Oct
Complementation tests and deletion mapping
Ch. 6
6
16
Thursday
11-Oct
Ch. 6
6
Friday
12-Oct
Complementation tests and deletion mapping;
17
Monday
15-Oct
Gene Transcription
Ch. 12
7
18
Wed
17-Oct
Gene Transcription
Ch.12
7
Thursday
18-Oct
Friday
19-Oct
Post-Transcriptional Processing
Ch. 12
7
Monday
22-Oct
EXAM 2 (covering lectures 10 to 18)
4, 5, 6, 12
8
Wed
24-Oct
Post-Transcriptional Processing
Ch. 12
8
Thursday
25-Oct
21
Friday
26-Oct
Transcriptional Regulation in Eukaryotes
Ch. 15
8
22
Monday
29-Oct
Transcriptional Regulation in Eukaryotes
Ch. 15
9
23
Wed
31-Oct
Transcriptional Regulation in Eukaryotes
Ch. 15
9
Thursday
1-Nov
Friday
2-Nov
19
20
24
Quiz 1 Due
2
3
Quiz 2 Due
Ch. 4
3
Ch. 4
4
2, 3 & 4
4
4
5
Quiz 3 Due
Quiz 4 Due
6
7
Quiz 5 Due
8
9
Quiz 6 Due
Chromosomes: Change in Number
Ch. 8
9
25
Monday
5-Nov
Chromosomes: Structure; Natural Variation & Mutations
Ch. 8
10
26
Wed
7-Nov
Chromosomes: Polyploidy
Ch. 8
10
Thursday
8-Nov
27
Friday
9-Nov
Gene Mutation
Ch. 16
10
28
Monday
12-Nov
Gene Mutation
Ch. 16
11
29
Wed
14-Nov
Non-Mendelian Inheritance: X-inactivation & Imprinting
Ch. 7
11
Thursday
15-Nov
Friday
16-Nov
'EXAM 3 ( Lectures 19 to 28)
Monday
19-Nov
Non-Mendelian Inheritance: X-inactivation & Imprinting
Wed
21-Nov
THANKS GIVING BREAK: NO lecture
12
Thursday
22-Nov
THANKS GIVING BREAK NO lab Tues or Thurs
12
Friday
23-Nov
THANKS GIVING BREAK NO lecture
12
31
Monday
26-Nov
Non-Mendelian Inheritance/ Quantitative Genetics
Ch. 24
13
32
Wed
28-Nov
Quantitative Genetics
Ch. 24
13
Thursday
29-Nov
33
Friday
30-Nov
34
Monday
3-Dec
Quantitative Genetics; Population Genetics
35
Wed
5-Dec
Population Genetics
Thursday
6-Dec
36
Friday
7-Dec
Population Genetics
37
Monday
10-Dec
Population Genetics/ Review
Wed
12-Dec
EXAM 4 (Lectures 29-37)
30
10
Quiz 7 Due
11
Quiz 8 Due
11
Ch. 7
12
13
Quantitative Genetics
Quiz 9 due
Ch. 24
13
Ch 24, 25
14
Ch 25
14
14
Quiz 10 Due
Ch 25
14
Ch 25
15
Disputing a grade: if you feel your exam has been misgraded, you must submit a
written request for re-grade within a week of the day I have passed exams back (not the
day you picked it up). That request must be in writing accompanied by a copy of the
exam in question that I will keep.
Students With Disabilities are welcome in this class! If you need special
accommodations please contact me during office hours in the first week of class. This
includes students with diagnosed learning disabilities. If you feel you should be
evaluated for a learning disability please contact the Project Success office at 920 4241033 or go to their website at http://www.uwosh.edu/organizations/success.
Classroom Etiquette: please silence all pagers and cell phones; do not talk or whisper
unless called upon in turn (but feel free to raise your hand for a question or comment at
ANY time!).
Incomplete Grades may be given in extreme circumstances, such as when a student
becomes too ill to complete the semester's work. Please talk to me if you think your
situation warrants an "I" grade and be prepared to provide documentation.
15
Late Assignment Submissions may be penalized up to one grade point (e.g. from a B to
a C) at the Instructor's discretion.
Make up exams. If you cannot make one exam several alternatives may be available to
you depending on the rest of my teaching obligations at that time. I will do what I can,
given your circumstance. If you know ahead of time that you must miss an exam (for
instance if your job requires that you work that day) please let me know ahead of time.