Download Introduction to Genetics (Dorn)

BIO 340/343 INTRODUCTION TO GENETICS
LECTURER: Dr. Lisa Dorn
Spring 2008
OFFICE: HS 45; LAB: HS 47 PHONE: 424-3064; E-MAIL: [email protected]
OFFICE HRS: Mon 1:50pm to 3:50pm, Friday 1:50 to 3:50pm
LECTURE HOURS: 9:10 – 10:10 am in Halsey Science Building; Rm. 57
TEXT: Brooker, Genetics: Analysis & Principles (2nd edition) McGraw Hill.
OBJECTIVES: Genetics and its experimental methods is one of the broadest and most
rapidly evolving fields of science. I cannot possibly cover it all, so my goal is to teach
you how to think like a geneticist, while learning genetics concepts so that you can judge
for yourself the value of emerging genetic technologies and discoveries. This course
covers Mendelian genetics and its complications, the molecular basis of genes and their
affect on phenotypes, the methods of identifying and characterizing the genetic basis of
diseases and other phenotypes as well as population and evolutionary genetics.
The prerequisites for this course are Bio105 and 323, which by extension means you have
taken Chem 105 and 106 as well as Bio111. The laboratory part of this course will
expand on what you have learned in Molecular and Cell Biology (Bio 323). I will
assume you have mastered the Bio323 material and will not waste much time reviewing
this material but there will be some review of 323 materials in lab.
ASSESSMENT: How are you going to earn your grade?
EXAMS: 4 exams each worth 100 points. They will be mostly problems similar
to those in your D2L quizzes. (400 total points).
PROBLEM SOLVING: There will be 8 D2L problem-solving sessions where
you will be required to solve problems that will be available on D2L. Worth 10 points
each (total = 80 points). These problems are presented as quizzes. The problems will
be available 1 week before they are due. During those days, you may discuss potential
solutions with your peers and me but once you submit your answer you cannot change
them. You can only see the answers after the submission deadline.
***IMPORTANT***: D2L was behaving very badly last semester. Do not wait for
the last hour to submit your answers. If D2L crashes while you are submitting your
answers and you subsequently miss the deadline, I can help you on a case-by-case basis
but I will do so only once. To help alleviate this problem I will direct D2L to allow late
submissions but it will flag these submissions. If too many students are late repeatedly, I
will remove this feature. However, I may on occasion extend the deadline for a specific
quiz if there are questions that require last minute lecture material.
EXTRA CREDIT QUIZZES: There will be one extra credit quiz at the end of
the semester worth 5 points. Besides the extra credit, it will be very similar to questions
you will find on the last exam so I highly recommend that you do this. *NOTE: If extra
credit points from this quiz are the only way to pass the course that is acceptable.
HOWEVER, you will be offered extra credit points for attending the Celebration of
Scholarship in April and these points can not be used to pass the course.*
LABORATORY: Is worth 105 points. The lab syllabus is available separately.
Total Possible points = 585.
92 – 100% = A, 89-91% = AB, 82-88% = B, 79-81% = BC, 72 – 78% = C, 68 – 71% =
CD, 67 – 60% = D, below 60 = F.
Disputing a grade: if you feel your exam has been misgraded, you must submit to me a
request for re-grade within a week of the day I have passed exams back (not the day you
picked it up). That request must be in writing accompanied by a copy of the exam in
question that I will keep.
Students With Disabilities are welcome in this class! If you need special
accommodations please contact me during office hours in the first week of class. This
includes students with diagnosed learning disabilities. If you feel you should be
evaluated for a learning disability please contact the Project Success office at 920 4241033 or go to their website at http://www.uwosh.edu/organizations/success.
Classroom Etiquette: please silence all pagers and cell phones; do not talk or whisper
unless called upon in turn (but feel free to raise your hand for a question or comment at
ANY time!).
Incomplete Grades may be given in extreme circumstances, such as when a student
becomes too ill to complete the semester's work. Please talk to me if you think your
situation warrants an "I" grade and be prepared to provide documentation.
Late Assignment Submissions may be penalized up to one grade point (e.g. from a B to
a C) at the Instructor's discretion.
Make up exams. If you cannot make one exam several alternatives may be available to
you depending on the rest of my teaching obligations at that time. I will do what I can,
given your circumstance. If you know ahead of time that you must miss an exam (for
instance if your job requires that you work that day) please let me know ahead of time.
The schedule of lectures, exams and due dates for problems. There may be minor
changes to this schedule without notice. I will announce such changes in class.
Lec
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Day
Date
1
Monday
4-Feb
Mendels Laws; Monohybrids & Dihybrid Crosses
Chapter 2
1
2
Wed
6-Feb
Dihybrid Crosses & Pedigrees
Chapter 2
1
3
Friday
8-Feb
Pedigree Analysis; Probability Rules chi square Test
Chapter 2
1
4
Monday
11-Feb
Chromosomes; Meiosis & Mendel's rules
Chapter 3:
2
5
Wed
13-Feb
Sex chromosomes; Sex-Linked Traits
Chapter 3:
2
Thursday
14-Feb
6
Friday
15-Feb
Sex determination; recessive Lethals
Chapter 3/4
2
7
Monday
18-Feb
Pleiotropy; Incomplete Dominance; co-dominance
Chapter 4
3
8
Wed
20-Feb
Overdominance, Penetrance
Chapter 4
3
9
Friday
22-Feb
Complementation, Gene Interactions
Chapter 4
3
10
Monday
25-Feb
Linkage and Recombination;
Wed
27-Feb
EXAM 1 (covers up to lecture 9)
2 & 3, part 4
4
11
Friday
29-Feb
Linkage and Recombination;
Chapter 5
4
12
Monday
3-Mar
Mapping genes: dihybrid crosses
Chapter 5
5
13
Wed
5-Mar
Trihybrid crosses
Chapter 5
5
14
Friday
7-Mar
Intragenic Mapping, bacteriophage
Chapter 6
5
Saturday
8-Mar
15
Monday
10-Mar
Complementation tests and deletion mapping
Chapter 6
6
16
Wed
12-Mar
Complementation tests and deletion mapping;
Chapter 6
6
17
Friday
14-Mar
Complementation tests and deletion mapping;
Chapter 6
6
18
Monday
17-Mar
Chromosomes: Change in Number
Chapter 8
7
Wed
19-Mar
Exam 2 (covering lectures 10 to 17)
Friday
21-Mar
Chromosomes: Structure; Natural Variation & Mutations
Monday
24-Mar
SPRING BREAK
8
Wed
26-Mar
SPRING BREAK
8
Thursday
27-Mar
SPRING BREAK
8
Friday
28-Mar
SPRING BREAK
8
20
Monday
31-Mar
Chromosomes: Polyploidy
Chapter 8
9
21
Wed
2-Apr
Gene Mutation
chapter 16
9
23
Friday
4-Apr
Gene Mutation
chapter 16
9
24
Monday
7-Apr
Gene Mutation
chapter 16
10
25
Wed
9-Apr
Transcription
Chapter 12
10
Thursday
10-Apr
Friday
11-Apr
Chapter 12
10
19
26
Topics
Book
2
Quiz 1 Due
Quiz 2 Due
Week
Chapter 5
4
Quiz 3 Due
Quiz 4 Due
7
Chapter 8
7
Quiz 5 Due
Post-Transcriptional Processing
27
Monday
14-Apr
Post-Transcriptional Processing
Chapter 12
11
28
Wed
16-Apr
Transcriptional Regulation in Eukaryotes
Chapter 15
11
29
Friday
18-Apr
Transcriptional Regulation in Eukaryotes
Chapter 15
11
30
Monday
21-Apr
Transcriptional Regulation in Eukaryotes
Chapter 15
12
31
Wed
23-Apr
Non-Mendelian Inheritance:
chapter 7
12
Friday
25-Apr
'EXAM 3 ( Lectures 18 to 30)
32
Monday
28-Apr
Non-Mendelian Inheritance:
chapter 7
13
33
Wed
30-Apr
Non-Mendelian Inheritance
Ch. 7/24
13
34
Friday
2-May
Population Genetics
Ch. 25
13
Saturday
3-May
35
Monday
5-May
Population Genetics
Ch 25
14
36
Wed
7-May
Population Genetics
Ch 25
14
Thursday
8-May
Friday
9-May
Saturday
10-May
Monday
12-May
Population Genetics/ Review
Wed
14-May
EXAM 4 (Lectures 31-40)
37
38
Quiz 6Due
12
Quiz 7 Due
14
Population Genetics
Ch 25
14
Ch 25
15
Quiz 8 Due
EC Quiz 9 Due
15