Download Introduction to Genetics (Dorn)

BIO 340/343 INTRODUCTION TO GENETICS
LECTURER: Dr. Lisa Dorn
Fall 2006
OFFICE: HS 45; LAB: HS 47 PHONE: 424-3064; E-MAIL: [email protected]
OFFICE HRS: Mon 1:50pm to 3:50pm, Thurs 1:50 to 3:50pm
LECTURE HOURS: 9:10 – 10:10 am in Halsey Science Building; Rm. 268
TEXT: Brooker, Genetics: Analysis & Principles (2nd edition) McGraw Hill.
OBJECTIVES: Genetics and its experimental methods is one of the broadest and most
rapidly evolving fields of science. I cannot possibly cover it all, so my goal is to teach
you how to think like a geneticist, while learning genetics concepts so that you can judge
for yourself the value of emerging genetic technologies and discoveries. This course
covers Mendelian genetics and its complications, the molecular basis of genes and their
affect on phenotypes, the methods of identifying and characterizing the genetic basis of
diseases and other phenotypes as well as population and evolutionary genetics.
The prerequisites for this course are Bio105 and 323, which by extension means you have
taken Chem 105 and 106 as well as Bio111. The laboratory part of this course will
expand on what you have learned in Molecular and Cell Biology (Bio 323). I will
assume you have mastered the Bio323 material and will not waste much time reviewing
this material. There will be some review of 323 materials in lab.
ASSESSMENT: How are you going to earn your grade?
EXAMS: 4 exams each worth 100 points. They will be mostly problems similar
to those in your D2L quizzes. (400 total points).
PROBLEM SOLVING: There will be 10 D2L problem-solving sessions where
you will be required to solve problems that will be available on D2L. Worth 10 points
each except problem set 5 that is worth 15 points (total = 105 points). These
problems are presented as quizzes. The problems will be available 1 week before they
are due. During those days you are allowed to discuss potential solutions with your peers
and me but once you submit your answer you cannot change it. You can only see the
answers after you submit.
LABORATORY: Is worth 100 points. The lab syllabus is available separately.
Total Possible points = 605.
92 – 100% = A, 89-91% = AB, 82-88% = B, 79-81% = BC, 72 – 78% = C, 68 – 71% =
CD, 67 – 60% = D, below 60 = F.
The schedule of lectures, exams and due dates for problems. There may be minor
changes to this schedule without notice. I will announce such changes in class.
Lecture
number
1
2
Day
Monday
Wed
Date
29-Jan
31-Jan
Topics
Mendels Laws; Monohybrids & Dihybrid Crosses
Dihybrid Crosses & Pedigrees
Book
Chapter 2
Chapter 2
Week
1
1
3
Friday
2-Feb
Pedigree Analysis; Probability Rules chi square Test
Chapter 2
1
4
Monday
5-Feb
Chromosomes; Meiosis & Mendel's rules
Chapter 3:
2
5
Wed
7-Feb
Sex chromosomes; Sex-Linked Traits
Chapter 3:
2
Thursday
8-Feb
6
Friday
9-Feb
Sex determination; recessive Lethals
Chapter 3/4
2
7
Monday
12-Feb
Pleiotropy; Incomplete Dominance; co-dominance
Chapter 4
3
8
Wed
14-Feb
Gene dosage, Overdominance,
Chapter 4
3
9
Friday
16-Feb
Penetrance, Expressivity, complementation Problem Set 2 Due
Chapter 4
3
Monday
19-Feb
EXAM 1 (covers up to lecture 9)
2, 3 & 4
4
10
Wed
21-Feb
Gene interactions,
Chapter 4
4
11
Friday
23-Feb
Linkage and Recombination;
Chapter 5
4
12
Monday
26-Feb
Mapping genes: dihybrid crosses
Chapter 5
5
13
Wed
28-Feb
Trihybrid crosses, Interference (no haploid ):
Chapter 5
5
Thursday
1-Mar
14
Friday
2-Mar
Intragenic Mapping, bacteriophage
Chapter 6
5
15
Monday
5-Mar
Complementation tests and deletion mapping
Chapter 6
6
16
Wed
7-Mar
Complementation tests and deletion mapping;
Chapter 6
6
Thursday
8-Mar
17
Friday
9-Mar
Gene Transcription
Chapter 12
6
18
Monday
12-Mar
Gene Transcription
Chapter 12
7
19
Wed
14-Mar
Post-Transcriptional Processing
Chapter 12
7
Thursday
15-Mar
Friday
16-Mar
EXAM 2 (covering lectures 10 to 19)
Part 4, 5, 6
7
Monday
19-Mar
Spring Break
8
Wed
21-Mar
Spring Break
8
Friday
23-Mar
Spring Break
8
21
Monday
26-Mar
Post-Transcriptional Processing
Chapter 12
9
22
Wed
28-Mar
Transcriptional Regulation in Eukaryotes
Chapter 15
9
23
Friday
30-Mar
Transcriptional Regulation in Eukaryotes
Chapter 15
9
24
Monday
2-Apr
Transcriptional Regulation in Eukaryotes
Chapter 15
10
25
Wed
4-Apr
Chromosomes: Change in Number
Chapter 8
10
26
Friday
6-Apr
Chromosomes: Structure; Natural Variation & Mutations
Chapter 8
10
27
Monday
9-Apr
Chromosomes: Polyploidy (Chapter 26 p. 728 - 731)
Ch 8 & 26
11
28
Wed
11-Apr
Gene Mutation and DNA repair
chapter 16
11
20
Problem Set 1 Due
Problem Set 3 Due
Problem Set 4 Due
Problem Set 5 Due
Problem Set 6 Due
Thursday
Problem Set 7 Due
Friday
13-Apr
'EXAM 3 ( Lectures 20 to 28)
12, 15, 8
11
29
Monday
16-Apr
Non-Mendelian Inheritance: X-inactivation & Imprinting
chapter 7
12
30
Wed
18-Apr
Quantitative Genetics
Ch. 24
12
31
Friday
20-Apr
Quantitative Genetics
Ch. 24
12
32
Monday
23-Apr
Quantitative Genetics
Ch. 24
13
33
Wed
25-Apr
No Class
Thursday
34
35
36
37
38
39
13
Problem Set 8 Due
Friday
Monday
Wed
Thursday
Friday
Monday
Wed
27-Apr
30-Apr
2-May
No Class
Quantitative Genetics; Population Genetics
Population Genetics
4-May
7-May
9-May
Population Genetics
Population Genetics
Friday
11-May
EXAM 4
Ch 25
Ch 25
13
14
14
Problem Set 9 Due
Ch 25
Ch 25
Problem Set 10 Due
24, 25, 7 &
16
Disputing a grade: if you feel your exam has been misgraded, you must submit to me a
request for re-grade within a week of the day I have passed exams back (not the day you
picked it up). That request must be in writing accompanied by a copy of the exam in
question that I will keep.
Students With Disabilities are welcome in this class! If you need special
accommodations please contact me during office hours in the first week of class. This
includes students with diagnosed learning disabilities. If you feel you should be
evaluated for a learning disability please contact the Project Success office at 920 4241033 or go to their website at http://www.uwosh.edu/organizations/success.
Classroom Etiquette: please silence all pagers and cell phones; do not talk or whisper
unless called upon in turn (but feel free to raise your hand for a question or comment at
ANY time!).
Incomplete Grades may be given in extreme circumstances, such as when a student
becomes too ill to complete the semester's work. Please talk to me if you think your
situation warrants an "I" grade and be prepared to provide documentation.
Late Assignment Submissions may be penalized up to one grade point (e.g. from a B to
a C) at the Instructor's discretion.
Make up exams. If you cannot make one exam several alternatives may be available to
you depending on the rest of my teaching obligations at that time. I will do what I can,
given your circumstance. If you know ahead of time that you must miss an exam (for
instance if your job requires that you work that day) please let me know ahead of time.
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