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phagocytic
leukocyte
“Fighting the
Enemy Within”
Immune System
AP Biology
lymphocytes
attacking
cancer cell
lymph
system
2006-2007
Avenues of attack
 Points of entry
digestive system
 respiratory system
 urogenital tract
 break in skin

 Pathways for attack
circulatory system
 lymph system

Regents Biology
Why an immune system?
 ___________________________________


lots of organisms want you for lunch!
we are a tasty vitamin-packed meal
 cells are packages of macromolecules
 no cell wall

___________________________________
 _____________________
 HIV, flu, cold, measles, chicken pox, SARS
 _____________________
 pneumonia, meningitis, tuberculosis
 _____________________
 yeast
 _____________________
 amoeba, Lyme disease, malaria

___________________________________
 __________________________
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What’s for
lunch?!
How are invaders recognized?
 ____________________________________

____________________________________
____________________________________
 “self” vs. “invader”
one of your
own cells
disease-causing
virus
disease-causing
bacteria
antigens say:
“I belong here”
antigens say:
“I am an invader”
antigens say:
“I am an invader”
Regents Biology
Lines of defense
 ____________________________

broad, external defense
 “walls & moats”

____________________________
 ____________________________

broad, internal defense
 “patrolling soldiers”

____________________________
 ____________________________

specific, acquired immunity
 “elite trained units”

____________________________
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 B & T cells
1st line: Physical Barriers
 non-specific defense
 external barriers


______________________
______________________
 _________________
 _________________
 _________________
 _________________
 _________________
 “lick your wounds”
Regents Biology
Lining of trachea:
ciliated cells &
mucus secreting
cells
2nd: Generalist, broad range patrols
 Patrolling ________________________

__________________________________
__________________________________
 _____________________________________
_____________________________________
 surface name tag

phagocyte cells
 ____________________
 “big eaters”
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Macrophage “eating” bacteria
Lymph system
Production of white blood cells &
traps “foreign” invaders
lymph vessels
(intertwined amongst blood vessels)
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2nd
“circulatory” system
lymph node
Phagocytes
macrophage
bacteria
white blood cells that eat
macrophage
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yeast
Why do injuries swell?
 Inflammation

injured cells release chemical signals
Pin or splinter
 _____________
 increases blood
flow
 brings more
white blood
cells to fight
bacteria
 brings more red
blood cells &
clotting factors
to repair
Regents Biology
Bacteria
Blood clot
Swelling
Chemical
alarm
signals
Phagocytes
Blood vessel
Fever
 When a local response is not enough

full body response to infection

raises body temperature

higher temperature helps in defense
 slows growth of germs
 helps macrophages
 speeds up repair of tissues
Regents Biology
3rd line: Lymphocytes
 Specific defense

responds to specific
invaders
 recognizes specific
foreign antigens
 ___________________________
 ___________________________
___________________________
 ___________________________
Regents Biology
B cell
B cells & antibodies
 ___________________________
white blood cells that attack
invaders in blood
 mature in Bone marrow

 Plasma B cells

____________________________________
 Memory B cells

____________________________________

can make antibodies quickly the next time
 protects you from getting disease more than once
Regents Biology
Antibodies
 Proteins made by B cells that tag invaders in
the blood so macrophages can eat them

tag says “this is an invader”  gotcha!
 biological handcuffs

__________________________________
B cells
releasing antibodies
Y
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Y
Y
Y
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invading germs tagged
with antibodies
Regents Biology
Y
Y
Y Y
Y
Y
macrophage
eating tagged invaders
Y
B cells immune response
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
“reserves”
Y YY Y
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Y
Y Y memory B cells
Y
Y
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recognition
B cells
Y
Y
Y
Y
Y
Y
B cells
release
antibodies
patrol blood
forever
Y
Y
Y
Y
Y
Y
Y
(foreign antigen)
Y
Y
Y
invader
Y
Y
10 to 17 days
Y
Y
Y
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Y
Y
Vaccinations
 ____________________________________
____________________________________

____________________________________
____________________________________

rapid response if
future exposure
 Most successful
against viral diseases
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1914 – 1995
Jonas Salk
 Developed first vaccine

against polio
April 12, 1955
Regents Biology
Polio epidemics
1994:
Americas polio free
Regents Biology
Protecting you from disease
 ________________________

advantage
 don’t get illness
 long term immunity
 produce antibodies for life
 works against many viruses
& bacteria

IMPORTANT
PROTECTION
 disadvantage
 not possible against all invaders antibodies pass
from mother to
________________________
baby in breast
milk
 mother’s milk gives baby
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antibodies & keeps baby healthy
What if the attacker gets past
the B cells in the blood &
infects some of your cells?
You need trained assassins
to kill off these infected cells!
T
AP Biology
Attack
of the
Killer T cells!
2006-2007
T cells
 T cells mature in Thymus
 Helper T cells

_________________________
________________________
 Killer T cells

_____________________________
 Memory T cells

remembers invader & reacts
against it again quickly
Where’s that?
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Thymus
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Attack of the Killer T cells
 ____________________________________
T cell binds to invaded cell
 secretes perforating protein

 punctures cell membrane of infected cell
 cell bursts
Killer T cell
Vesicle
Cell
membrane
Perforin
punctures
cell membrane
Cell
membrane
Regents Biology
Invaded cell
Immune response
invader
skin
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y Regents Biology Y
Y
Y
Y
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Y
Y
Y
invaders infect cells
Y
Y
invaders in blood
skin
Diseases of the immune system
 HIV: Human Immunodeficiency Virus
__________________________
 helper T cells can’t activate rest of
immune system

 body doesn’t hear the alarm
 AIDS:
Acquired ImmunoDeficiency Syndrome

____________________________________
____________________________________
 death usually from other
diseases or cancer

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Curing you of disease
 _____________________________

advantage
 kill bacteria that have successfully
invaded you
 make you well after being sick

disadvantage
 use only after sick
 only good against bacteria
 possible development of
resistance by bacteria
(if don’t use correctly)
 can get sick again
Regents Biology
Immune system malfunctions
 __________________________

immune system attacks own cells
 lupus
 antibodies attack many different
body cells
 rheumatoid arthritis
 antibodies causing damage to
cartilage & bone
 diabetes
 insulin-making cells of pancreas
attacked & destroyed
 multiple sclerosis
 T cells attack myelin sheath of
brain & spinal cord nerves
 fatal
Regents Biology
Immune system malfunctions
 Allergies

___________________________________
 allergens
 proteins on pollen
 proteins from dust
mites
 proteins in animal
saliva
 body mistakenly
thinks they are
attackers
Regents Biology
Blood type: antigens & antibodies
blood type
antigen
on RBC
antibodies
in blood
Who you
can donate
to
Can
Receive
A
___________
antigens
on surface of RBC
___________
antibodies
___
__________
B
___________
antigens
on surface of RBC
___________
antibodies
___
__________
AB
________________
___
antigens on
surface of RBC
______
antibodies
__________
___
__________
__________
O
________________
on surface of RBC
_____________
___ antibodies
___
__________
__________
___
Matching compatible blood groups is critical for blood transfusions
A Regents
personBiology
produces antibodies against foreign blood antigens
Blood donation
Regents Biology
It’s safe
to ask Questions!
AP Biology
2009-2010