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Beta-1,3/1,6-Glucan
Presented by
Mikuni Immune
www.mikuniimmune.com
Exclusive Importer for Sophy, Japan
Mikuni Immune
• The key to good health is a healthy immune
system however; your immune system can be
compromised by germs, pollution, and stress.
Clinical studies have shown that Mikuni
Immune Beta-1,3/1,6-Glucan helps support
your immune system. Our unique harvesting
process results in a product of exceptionally
high quality and purity.
Laboratory studies on Mikuni
Beta Glucan show the
following health effects:
• Support healthy lymphocyte levels *
• Produces cytokines which is essential to proper
immune function*
• Support regulation of receptors important to
healthy immune response*
• Supports the body’s ability to fight free radicals*
• Supports activation of natural killer cells*
Mikuni Beta Glucan culture fluid may
have a healthful effect on the
following:
• May mitigate menopausal discomfort
• Supports the systems that neutralize free
radicals
• Helps relieve occasional constipation or
irregularity
• Supports healthy immune resistance
• Supports healthy hair growth
• Supports physical strength
What is Beta Glucan?
Molecular Structure of
Beta-1,3/1,6-Glucan
A Polysaccharide (sugar) formed from
linking many glucose molecules together.
The molecular structure (linkage) of Beta
Glucan is a combination of its main and
side chains. The structure, 1,3/1,6,
whereby 1,3 is the main chain and 1,6 is
the side chain, is the most effective
immune booster.
How Does it Work?
• Mikuni Beta Glucan safely supports your immune
system and your body’s natural defenses.*
• Studies in vitro and in animals support the
immune responses seen in humans.*
• Our product is completely pure; harvested during
the natural growth of yeast while the yeast cells
are in the process of reproducing.
• Contains only the 1,3/1,6 linkage, that has been
shown through clinical trials to be the most
bioactive immune stimulator.
Why it is Superior?
• Made with ingredients from U.S. patent No.
6,956,120 B2
• Uniformity of size of particles
• It has a Beta-1,3/1,6 linkage to support the immune
system that makes it unlike the Beta-1,3/1,4 linkages
found in oats or oat fibers
• Has been rated by the FDA as GRAS (Generally
Recognized As Safe)
Superior Immune Support
Mikuni Immune
Beta-1,3/1,6-Glucan
Derived from Black Yeast
(Aureobasidium pullulans)
{NOT BAKERS YEAST}
• A PROMISING PRODUCT DEVELOPED OVER 30
YEARS SUPPORTED BY NUMEROUS CLINICAL
STUDIES BY LEADING JAPANESE PHYSICIANS.
History of Beta-1,3/1,6-Glucan
Beta Glucan research began in 1941 with the
discovery of the immune-activating substance
called Zymosan which is an immunoactive
substance from yeast walls.
In the 1960’s an apparent explanation on this
question was given when a research group
discovered that the active component of
Zymosan was Beta-1,3-1,6-Glucan.
History of Beta-1,3/1,6-Glucan
(cont.)
Over 30 years ago, inventors Nobunao Ikawaki,
Nobouru Fujii, & Takashi Onaka traveled to
Norway to visit a fishery where the fish were not
receiving any antibiotics or additives, yet
remained very healthy. The inventors learned
that the fish were being fed glucan. As the result
of their discovery, they received a grant from the
Japanese Government to research this in state
owned hospitals.
History of Beta-1,3/1,6-Glucan
(cont.)
In 1996, SOPHY B-glucan under the trade name
Aureobasidium (a scientific name for black yeast)
Cultured Solution became the first B-glucan to be
approved by Japan’s Ministry of Health, Labor &
Welfare as an existing food additive (also called a
‘natural food additive’), thus gaining official
recognition as being safe for use as an ingredient in
food. SOPHY B-glucan has transcended the
boundaries of conventional health food & now is
used to provide added functionality as an additive in
ordinary food & cuisine.
About Us
The primary goal of Mikuni Immune is to contribute to society
globally by offering the highest quality, pure Beta-1,3 /1,6-Glucan
available derived from a natural product that is effective and safe
for people, animals and the environment.
Mikuni Beta-1,3 /1,6-Glucan is derived from the black yeast,
Aureobasidium pullulans, cultivated in Japan and harvested
under sterile conditions.
Produced by SOPHY Corporation, Japan
Exclusively Imported By Mikuni Immune
More about SOPHY B-Glucan
• Is being used by Shiseido – a top of the line
international cosmetics company – in products
for anti-aging & sun protection.
• For Pet Food and supplements
• Contains no proteins, fat, fillers, or
contaminates that could be toxic
The characteristics of SOPHY Bglucan as an ingredient is not
limited to food products:
• Live stock farming
• Pharmaceutical or medical products or
treatments.
• Nutritional products
• In diagnostic products & methods
Clinical Studies: (Sophy Beta1,3/1,6-Glucan) Japan
Date: Jan 15, 2011 The 14th Annual Assembly of Japan
Society of Metabolism and Clinical Nutrition. Presented by
Sasaoka et al.
Patients were given Sophy beta glucan. 18 patients took
15mL 3 times per day for 3 months. Blood was drawn
prior to administration of beta glucan. Natural Killer Cell
activity was measured and examined each time. NK cell
activity was increased in 1 month(126.4±13.76.%), 2
months (129.7±10.24%), and 3 months (116.2±8.36%)
time period. Beta glucan appears to induce cell immunity
and thereby may be beneficial in helping to support
immune system function.
Clinical Studies: (Sophy Beta1,3/1,6-Glucan) Japan
(cont.)
Date : Jan 29, 2009 The 24th Assembly of Japanese Society for Parenteral
and Enteral Nutrition. Presented by Yano et al.
Immunostimulatory effects of Sophy beta glucan in humans. Study on 29
healthy individuals. Group 45ml: 11 people took Sophy beta glucan 45ml a
day (15ml each, 3 times a day) for a month. NK activity was measured by
51Cr- release assay.
Group 5ml: 9 people took 5 ml a day
Group 30 ml: 9 people took 30 ml a day
In Group 45 ml, 90.9 % (10/11) of the people had an increase of NK activity.
The NK activity increased from 100% (before intake) to 122.5 ±8.48%
(p=0.0213) and it was statistically significant. After stopping taking, NK
activity decreased to the original level in 62.5 % of the people. The data
were statistically significant (p=0.0002, p=0.0402). Sophy beta glucan was
proved to increase immunostimulatory effects in human. The effect depends
on the duration of intake.
References:
Ikewaki N, Fujii N, Onaka T, Ikewaki S, Inoko H. Immunological actions of Sophy beta-glucan (beta-1,3-1,6
glucan), currently available commercially as a health food supplement. Microbiol
Immunol. 2007;51(9):861-873.
Ikewaki N, Fujii N, Onaka T. et al. Immunologic responses of human peripheral blood mononuclear cells
(PBMCs) derived from healthy donors cultured with β-1,3-D/1,6 glucan produced by Aureobasidium
pullulans. J of Kyushu University of Health and Welfare. 2005;6:193-198.
Ikewaki N, Fujii N, Onaka T, Inuko H. Unique immunological actions of a new β-1,3-D/1,6 glucan (Sophy βglucan) produced by Aureobasidium pullulans strain AFO-202. J of Clin Immun 2000;20:4:317-324.
Yatawara L, Wickramasinghe S, Nagataki M, Takamoto M, Nomura H, Ikeue Y, Watanabe Y, Agatsuma T.
Aureobasidium-derived soluble branched (1,3-1,6) beta-glucan (Sophy beta-glucan) enhances natural killer
activity in Leishmania amazonensis-infected mice. Korean J Parasitol. 2009 Dec;47(4):345-51.
The adjuvant effect of Sophy β-glucan to the antibody response in poultry immunized by the avian
influenza A H5N1 and H5N2 vaccines. Le T, Le T, Doan TH, Quyen D, Le KX, Pham V, Nagataki M, Nomura H,
Ikeue Y,
Watanabe Y, Agatsuma T. J Microbiol Biotechnol. 2011 Apr;21(4):405-11.
Effects of Sophy β-glucan on growth performance, carcass traits, meat composition, and immunological
responses of Peking ducks. Tang XY, Gao JS, Yuan F, Zhang WX, Shao YJ, Sakurai F, Li ZD. Poult Sci. 2011
Apr;90(4):737-45.
Effect of Sophy β-glucan on immunity and growth performance in broiler chicken. Rajapakse JR, Buddhika
MD, Nagataki M, Nomura H, Watanabe Y, Ikeue Y, Agatsuma T.
J Vet Med Sci. 2010 Dec;72(12):1629-32. Epub 2010 Jul 21.
Personal Testimonials
I'm in my 40's and due to my family history, I was concerned about
maintaining my health. I took Mikuni Beta Glucan 500mg daily for six
months, and along with diet changes and regular exercise I am confident
that I can stay healthy. My doctor is amazed! I continue to take 250mg
of Mikuni Beta Glucan daily to compliment my healthy lifestyle
changes. Toby Scott, San Diego CA
After recovering from a respiratory infection I wanted to do something
to keep my immune system strong. Along with limiting my exposure to
allergens by getting dust mite covers for my bedding and limiting
exposure to second hand smoking, I began taking 400mg of Mikuni Beta
Glucan per day mixed in my green tea. I would recommend it to anyone
to help support their immune system. Dennis Burnham, Poway CA
Product of 250mg x 30 capsules
Label
Serving Size:
Take 1 capsule, 250 mg daily
Contains no:
Dairy, Lactose, Egg, Corn,
Soy, Wheat, Gluten, Starch,
Preservatives, or Artificial
colors
Laboratory tested and
Quality Guaranteed.
• To activate your immune
system, start with 2
capsules per day
(500mg). Take one in the
AM and one in the PM for
two weeks