Download Why Stem Cells - Stem Cell Banking

Bank your Baby’s
Cord Blood Stem Cells
and secure your family’s Health
@
“Your Stem Cell Bank”
Why Stem Cells ?
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Self renewal capacity.
Long term culture mode.
Elevated proliferation rate.
Insignificant response to naïve cord blood T cells.
Extremely high probability of cure.
Master cells.
Repair, Regenerate & Replace damaged cells.
Form heart, liver, nervous system, spinal cord etc.
Over 200 types of tissues – Clinical significance.
Ability to divide, differentiate continuously – to
address diseases like Heart failures, Alzheimer’s,
Parkinson’s, Thalassemia, Leukemia, Liver,
Diabetes problems.
Sources of Stem Cells
Blastocyst
Birth
Adult
CBSC
UCSC
ASC
PSC
ASC
BMSC
Stem Cell
Fetal source
ESC-P
FTSC
P,M
P, M
P, M
FTSC-Fetal Tissue Stem Cells
CBSC-Cord Blood Stem Cells
UCSC-Umbilical Cord Stem Cell
ASC-Amniotic Stem Cell
PSC-Placental Stem Cell
ASC-Adult Stem Cell
BMSC-Bone Marrow Stem Cell
Umbilical Cord/Blood
• Umbilical Cord/Blood Stem
Cells
• Traditional discard - byproduct of the birth process
• Multipotent - stem-cell - rich
blood found in the umbilical
cord has proven useful in
treating the diseases
• Umbilical cord blood stem cell
transplants - less prone to
rejection than either bone
marrow or peripheral blood
stem cells - the cells have not
yet developed the features that
can
be
recognized
and
attacked by the recipient's
immune system
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Also, because umbilical cord blood lacks welldeveloped immune cells, there is less chance
that the transplanted cells will attack the
recipient's body, a problem called graft versus
host disease
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Versatility and availability of umbilical cord
blood
stem cells
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potent resource for
transplant therapies
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These cells have no morbidity, it is possible to
isolate huge numbers and they do not belong
to an ethically controversial source
Fewer limitations - not tumorigenic, maintain for several serial passages - short population doubling time
Advantages...
Cord/Blood Source
• Collection process is easy
• There is no harm done
either to the mother or the
baby
• High probability of HLA
matching
• Medical waste – Rich
source of high therapeutic
potential stem cells
Cord Blood Easier & Safer
Adult Stem Cells
• Peripheral Blood Stem Cells
• While most blood stem cells reside in the bone
marrow, a small number are present in the
bloodstream. These multipotent PBSCs, can be used
just like bone marrow stem cells to treat leukemia,
other cancers and various blood disorders
• PBSCs are easier to collect than bone marrow stem
cells
• PBSCs - less invasive treatment option than bone
marrow stem cells
• PBSCs are sparse in the bloodstream
Collecting enough to perform a transplant can pose challenge
Adult Stem Cells - Sources
Present throughout the body from head to toe
• Brain
• Liver
• Skin
• Dental pulp
• Adipose tissue
• Placenta
• Menstrual blood
• Synovial fluid
• Umbilical cord
• Heart
• Pancreas
• Intestine
Adult Stem Cells
Bone Marrow
Mesenchymal
Stem Cells
Hematopoietic
Stem Cells
MSC are the most preferred cell types in clinical
applications
During the past 50 years, intensive studies into the
characteristics of
hematopoietic stem cell transplantation
immunology with the emergence of new immunosuppressant
and anti-infective drugs have significantly improved the clinical
result of hematopoietic stem cell transplantation .
Advantageous Features
• Already
somewhat
specialized:
Inducement may be simpler
• Immune hardy: Recipients who receive the
products of their own stem cells will not
experience immune rejection
• Flexible: Adult stem cells may be used to
form other tissue types
• Mixed degree of availability: Some adult
stem cells are easy to harvest and others,
such as neural (brain) stem cells, can be
dangerous to the donor
The surprising property of adult stem cells: transdifferentiation
CB Stem Cells – For
Patients Suffering from
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Acute Leukemia
Chronic Leukemia
Myelodysplastic Syndrome
Myeloproliferative Disorder
Lymphoproliferative Disorder
Familial Erythrophagocytic
Lymphohistiocytosis
Histiocytic Disorder
Inherited Metabolic Disorder
Platelet Abnormality
Plasma Cell Disorder
Thalassemia
Other Malignancies
What is a Stem cell
transplant?
• Infusion of healthy cells to
replace
diseased
or
damaged ones
• The
healthy
replacement stem cells
will integrate into the
body and give rise to
more cells that can all take
on the necessary functions
for a specific tissue
Diseases Treatable by
Stem Cell Transplantation
Today
• Leukemia's
• Lymphomas
• Multiple myeloma
• Radiation sickness
• Autoimmune Dx
• Tissue repair and Burns
• Breast and Ovarian cancers
Near Future
• Diabetes
• Cardiovascular Dx
• Spinal Cord Injuries
• Skin Rejuvenation
• Rheumatologic
• Orthopedics
• Stroke
Sources include: www.marrow.org; www.viacord.com; www.cryo-cell.com
Stem Cells in Gynecology & Obstetrics
For
Solid Tumors
Renal Carcinoma
Melanoma
Ovarian Cancers
Metastatic Breast Cancers
In utero HSC transplantation
In vitro Generation of Gamestes
Treating
Abdominal Wall Defects
Umbilical Hernia
Spina Bifida
Flexibility
Who Should Bank Their
Stem Cells
• Health conscious individuals
• Individuals with family history of cancer, diabetes
and heart diseases
• Individuals diagnosed with cancer
• Individuals - exposed to toxins or harmful
radiation because of their jobs
• “First responders”, who may be exposed to lethal
levels of radiation
Why Tran-Scell ?
• Tran-Scell is state of the art stem cell banking
and processing centre.
• Tran-Scell is highly equipped with expertise
and
optimal
microenvironment
for
processing and preserving your child’s
precious stem cells for all the potential future
medical requirements.
• Personal commitment from enrollment,
collecting the source, processing the stem
cells, cryopreserving the customized stem
cell units for future therapeutic options,
reporting associated with safe service
delivery.
• Stringent quality control and quality assurance
ensured.
• Standard operating procedures and automated
processing protocols followed.
• Samples are stored in an fire and earthquake
proof vaults with 24x7 monitored ambience.
• Emergency UPS, Access restriction systems and
Backup arrangements installed.
Services @ Tran-Scell
• Umbilical Cord Blood Collection, Processing &
Storage of Haemopoitic stem cells.
• Umbilical Cord Tissue Collection, Processing, Cell
expansion & Storage of harvested Mesenchymal
stem cells.
• Processing of Bone Marrow for adult stem cells &
storage.
• Processing & storage of Peripheral Blood stem
cells.
• Generation of stem cells from various sources for
therapeutic applications on various dread full
diseases.
• Private Banking facilities.
Research @ Tran-Scell
• Isolation & Expansion of Stem cells from Dental
Pulp for therapeutic application on dental
disorders.
• Isolation & Expansion of Acinar cells from Human
lacrimal gland for treating Dry eye syndrome.
• Isolation of stem cells from Human adipose tissue.
@ Tran-Scell?
Safety and Security
• Tran-Scell maintains optimal conditions for
processing and storing stem cells
• Quality control measures for each stage of
the stem cell banking process
Processing
• Automated Processing using SEPAX.
• Manual processing allows trained scientists
to perform quality control at every step
• Standard Operating Procedures – Batch wise
specifications
• Certificate of Analysis of the final finished
personalized product
• On average, the process employed recover
over 90% of total nucleated cells and high
density of mesenchymal stem cells from the
sample
Storage
• Initial quarantine
• Long-term storage in liquid nitrogen
maintains temperatures at -196°C, far
below the recommended minimum
standard for storage at -150°C
• On-site tank feeds a constant supply of
liquid nitrogen, even during a power
outage
• Electronic systems constantly monitor
temperature and liquid nitrogen levels
• Functional In-built remote alarm
system
Advantage with
Tran-Scell
FDA APPROVED REAGENTS
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HLA for every sample
Associate Banking
Formulation
For Immediate Therapy & Future Applications
Application Specific
Duplicates – Multiple Vials
Expansion – Whole Diseases Management
Automated and Semi automated process
Regenerative medicine factor
“Alone we can do so little;
together we can do so much.”
Thank You