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The CVS is the First major system to function in the embryo. The primordium of the heart Begins at (18) days. It appears as: Aggregation of Splanchnic Mesenchymal cells in the Cardiogenic Area (ventral to the pericardium). The cells arrange themselves to form: Two Longitudinal Cellular Cardiac Primordia. This is under the influence of the embryonic endoderm. The cords canalized and become thin walled. As a result of lateral folding: The tubes approach each other and begin to fuse. Fusion of the tubes begin: At the Cranial end of the developing heart. It extends Caudally. A Single Endocardial Tube is formed. The First Beats are detected at: 22- 23 Days. Blood Flow: Starts during the 4th week. This can be detected by Doppler ultrasonography. It is part of the Intraembryonic Celomic Cavity. It lies over the Horse Shoe –Shaped Cardiogenic area. The heart and pericardial cavity come to lie: Ventral to the foregut. Caudal to the oropharyngeal membrane. This is a result of head folding. The cardiac tube is attached to the dorsal side of the pericardial cavity by Dorsal Mesocardium. Ventral Mesocardium. is Never formed. Transverse Sinus: It is between the right and left sides of the pericardial cavity. It is formed by: Degeneration of the Central part of the Dorsal Mesocardium. Endocardium: It is the Endothelial tube. Primordial Myocardium: It is the Splanchnic Mesoderm surrounding the pericardium. Cardiac Jelly: A gelatinous layer which separates the two. Epicardium : Derived from cells in the external surface of the sinus venosus. It elongates and forms Constrictions and Dilatations : Truncus arteriosus. Bulbus cordis. Ventricle. Atrium. Sinus venosus. The Bulbus Cordis and Ventricle grow faster than the others. The cardiac loop bends upon itself. The Cranial part bends: Ventrally, Caudally and to the Right. The Atrial portion shifts : Dorso Cranially and to the Left. It is U-shaped. It has : Cranial Arterial End: Truncus Arteriosus. Aortic sac. Aortic Arches. It is fixed through the pharyngeal arches. Caudal Venous End It is fixed to the Septum Transversum. A separate chamber. It opens into: The center of the dorsal wall of the primitive atrium. It has: Right and Left Horns of the same size. Each Horn receives (3) Veins: 1. Common Cardinal (from the embryo). 2. Umbilical (from the placenta). 3. Vitelline (from the yolk sac). The Sinoatrial Orifice moves to the Right Because of: Obliteration of the following veins: Right Umbilical. Left Vitelline. Left Common Cardinal. The left horn becomes : Coronary Sinus. The right horn: Incorporated into the Right Atrium. It has: Smooth part: Incorporated from Sinus Venarum Rough trabeculated part: Derived from the primordial atrium. The two parts are demarcated by The Crista and Sulcus Terminalis (internally and Has right and left venous valvular folds (venous valves). Right Valve: Cranial part : Crista Terminalis Caudal part : valves of Coronary Sinus and IVC. Left Valve : Incorporated into the Interatrial Septum. The Rough Trabeculated Left Auricle: From the primordial atrium. The smooth part: From incorporation of the primordial Pulmonary Vein. The (4) pulmonary veins are formed from: Gradual incorporation of the pulmonary vein and its main branches into the wall of the expanded atrium.