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Anatomic overview. (A) The nuclei and course of cranial nerves (CNs) III, IV, and VI are shown. CN IV is the only cranial nerve to exit the dorsal brainstem. All three ocular motor nerves travel through the cavernous sinus to enter the orbit. (B) Cavernous sinus (coronal view). CNs III and IV travel in the lateral wall of the sinus, but CN VI occupies a more vulnerable mid-cavernous route. The first (ophthalmic) branch of the trigeminal nerve (V1) traverses the length of the sinus to enter the orbit through the superior orbital fissure; the second (maxillary) branch (V2) exits mid-cavernous sinus; and the third (mandibular) branch (V3) may variably have a brief appearance in the posterior cavernous sinus (not pictured). Source: Ocular Motility Disorders: Cranial Nerve Palsies, Practical Neuroophthalmology Citation: Martin TJ, Corbett JJ. Practical Neuroophthalmology; 2013 Available at: http://mhmedical.com/ Accessed: May 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved