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Introduction to Anatomy and Physiology History of Anatomy • Early interest from desire to live through injuries and illnesses • Primitive healers learned medicinal value of herbs and potions • Ancient peoples believed that natural processes caused by spirits and supernatural forces Trepanation • Process of opening the skull • Used in primitive days to release evil spirits from head • As you can guess – high mortality • Still done today – Subdural hematomas History of Anatomy • Alcmaeon – c. 400 BC – First known scientist to perform dissection. Searching for human intelligence (still ongoing?) • Herophilus – c. 300 BC – Human vivisection • Galen – AD 158 – dissection of apes and pigs. Overturned idea that arteries contain air. • Vesalius – AD 1533 – dissection of human corpses. De humani corporis fabrica libri septem • William Harvey – AD 1628. Proposes blood flows in a circulatory system with the heart as pump. • Microscope (Malpighi and Leeuwenhook) – first scientists to see capillaries and egg development De humani corporis fabrica libri septem (On the fabric of the human body in seven books) • Vesalius published his book at the age of 28. • It was often bound in human skin. What is Anatomy and Physiology? • Anatomy – the study of the structures and relationships between the parts • Physiology – the study of the function of body parts and the body as a whole • Anatomy will name a bone and its position while physiology will describe its function, growth, repair, and importance to rest of body • Movement - self initiated change in position, motion of internal parts • Responsiveness (irritability) - Ability to sense changes within, or around the organism and react to them • Growth - increase in body size • Reproduction - Parents produce offspring / producing new individuals • Respiration - Obtaining oxygen (O2), using it to release energy from food substances, and getting rid of wastes • Digestion - Chemically changing (breaking down) food substances, and getting rid of wastes • Absorption - Passage of Digested products (food substances) through membranes and into body fluids • Circulation - Movement of substances throughout the body • Assimilation - Changing absorbed substances into chemically different substances • Excretion - Removal of wastes • • • • • • • I am walking to Mcdonalds (movement) I stop at the traffic light (response) My body is growing (growth) I am breathing air (respiration) I get a hamburger and eat it (digestion) My body absorbs the hamburger (absorption) The hamburger circulates in my body (circulation) • The hamburger is changed to things my body needs (assimilation) • Eventually, I go to the bathroom (excretion) • Someday I may reproduce (reproduction) Levels of Organization • Chemical – atoms and molecules provide framework for all living activities • Cell – smallest unit of life; structural unit • Tissue – group of cells with common function • Organ – different tissues working together to perform activity Levels of Organization • Organ system – two or more organs working together to accomplish a task • Organism – obtain and process energy, respond to stimuli, and ability to reproduce Levels of Structural Organization Smooth muscle cell Molecules Cellular level Cells are made up of molecules Atoms Chemical level Atoms combine to form molecules Tissue level Tissues consist of similar types of cells Smooth muscle tissue Epithelial tissue Smooth muscle tissue Connective tissue Organ level Organs are made up of different types of tissues Blood vessel (organ) Cardiovascular system Organismal level Human organisms are made up of many organ systems Organ system level Organ systems consist of different organs that work together closely Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Figure 1.1 Levels of Structural Organization Molecules Atoms Chemical level Atoms combine to form molecules Figure 1.1, step 1 Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Levels of Structural Organization Smooth muscle cell Cellular level Cells are made up of molecules Molecules Atoms Chemical level Atoms combine to form molecules Figure 1.1, step 2 Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Levels of Structural Organization Smooth muscle cell Molecules Cellular level Cells are made up of molecules Atoms Chemical level Atoms combine to form molecules Tissue level Tissues consist of similar types of cells Smooth muscle tissue Figure 1.1, step 3 Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Levels of Structural Organization Smooth muscle cell Molecules Cellular level Cells are made up of molecules Atoms Chemical level Atoms combine to form molecules Tissue level Tissues consist of similar types of cells Smooth muscle tissue Epithelial tissue Smooth muscle tissue Connective tissue Blood vessel (organ) Organ level Organs are made up of different types of tissues Figure 1.1, step 4 Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Levels of Structural Organization Smooth muscle cell Molecules Cellular level Cells are made up of molecules Atoms Chemical level Atoms combine to form molecules Tissue level Tissues consist of similar types of cells Smooth muscle tissue Epithelial tissue Smooth muscle tissue Connective tissue Organ level Organs are made up of different types of tissues Blood vessel (organ) Cardiovascular system Organ system level Organ systems consist of different organs that work together closely Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Figure 1.1, step 5 Levels of Structural Organization Smooth muscle cell Molecules Cellular level Cells are made up of molecules Atoms Chemical level Atoms combine to form molecules Tissue level Tissues consist of similar types of cells Smooth muscle tissue Epithelial tissue Smooth muscle tissue Connective tissue Organ level Organs are made up of different types of tissues Blood vessel (organ) Cardiovascular system Organismal level Human organisms are made up of many organ systems Organ system level Organ systems consist of different organs that work together closely Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Figure 1.1, step 6 Organ Systems • 11 organ systems make up the organism: – – – – – – – – – – – Integumentary Skeletal Muscular Nervous Endocrine Cardiovascular Lymphatic Respiratory Digestive Urinary Reproductive • The organ systems work together, not in isolation Integumentary System Skeletal System Muscular System Nervous System Endocrine System Cardiovascular System Lymphatic System Respiratory System Digestive System Urinary System Reproductive System Anatomical Terminology • Anatomical Position – standing erect, facing forward, arms down at side with palms forward • Directional terms used to describe relative position of one part to another Directional Terms • • • • • • • • Anterior (Ventral) – front Posterior (Dorsal) – back Proximal – near Distal – far Lateral – to the side Medial - toward middle Superior – above Inferior - below Anterior Body Landmarks • Abdominal – anterior body trunk inferior to ribs • Acromial – point of shoulder • Antebrachial – forearm •Antecubial – anterior surface of elbow •Axillary – armpit •Brachial – arm •Buccal – cheek area •Carpal – wrist •Cervical – neck region •Coxal –hip •Crural –leg •Deltoid – curve of shoulder formed by large deltoid muscle •Digital – fingers, toes •Femoral – thigh •Fibular – lateral part of leg •Inguinal – area where thigh meets body trunk; groin •Nasal – nose area •Oral – mouth •Orbital – eye area •Patellar – anterior knee •Pelvic – area overlying the pelvis anteriorly •Pubic – genital region •Sternal – breastbone area •Tarsal – ankle region •Thoracic – chest •Umbilical - navel Posterior Body Landmarks •Calcaneal – heel of foot •Cephalic – head •Femoral – thigh •Gluteal – buttock •Lumbar – area of back between ribs and hips •Occipital – posterior surface of head •Olecranal – posterior surface of elbow •Popliteal – posterior knee area •Sacral – area between hips •Scapular – shoulder blade region •Sural – posterior surface of lower leg; calf •Vertebral – area of spine •Plantar (interior body) – sole of the foot Body Planes and Sections • To look at the internal structures of the body, physicians make a section, or cut. • When a section goes through an organ, it is along an imaginary line called a plane. Sagittal Section • Sagittal section – cut along lenthwise (logitudinal) plane of the body, diving into L and R •If L and R are equal and cut is down the median plane of the body, it is called a median or midsagittal section Frontal Section • Frontal section – cut along the lengthwise plane that divides the body into anterior and posterior parts. Also called a coronal section. Transverse Section • Transverse section – cut along a horizontal plane, dividing the body into superior and inferior parts. •Also called a cross section Body Cavities •Body cavities provide different degrees of protection to the organs within them. •There are two: dorsal and ventral. •Dorsal body cavity –two divisions: •Cranial cavity – space inside skull •Spinal cavity – extends from cranial cavity to end of vertebral column. •Vertebrae surround spinal cavity Body Cavities •Ventral body cavity is much larger than the dorsal cavity. •Contains all structures within the chest and abdomen •Subdivisions: •Superior thoracic cavity – separated by diaphragm •Protected by rib cage •Abdominopelvic cavity •Abdominal cavity – contains stomach, liver, intestines •Pelvic cavity – reproductive organs, bladder, rectum Quadrants of Abdominopelvic Cavity Regions of Abdominopelvic Cavity Anterior view of ventral body cavity Homeostasis • Conditions remaining relatively stable • Response of an organism to stimuli maintains homeostasis of the organism • Operates on a negative feedback cycle. Negative Feedback • Control center in brain, set point at 37°C. • When body temp climbs above 37.2°C, heat loss is increased through blood flow to skin. • Similar to thermostat, with set point and effector response to return to normal temp. • What is an example of positive feedback? – Labor. Oxytocin is a hormone that stimulates uterine contractions. As contractions occur more oxytocin is released and so on. Homeostasis • All homeostatic control mechanisms have: • Receptor – sensor that monitor and responds to changes in environment (stimuli) – Afferent pathway from receptor to control center • Control Center – determines the level at which a variable is to be maintained and determines appropriate response • Effector – controls means for response – Efferent pathway from control center to effector Homeostasis Homeostasis • Body temperature is an example of something that the human body maintains through homeostasis = human thermoregulation • Example: Heat • Receptor? – Skin cells • Control Center? – Hypothalamus • Effector? – Sweat glands secrete sweat; causing heat loss by evaporative cooling