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“Optical Tracking of Molecular Processes at High
Resolution with a Novel Traveling Wave Technique”
Irene Dujovne
Postdoctoral Fellow, Technical University of Delft
Friday, March 30, 2007 10:00 a.m.
LSC 220-2
In order to understand the basic mechanisms of living cells, it is essential to
elucidate the complexity of fundamental interactions and dynamical processes
between their underlying molecular building blocks, such as DNA, RNA, and
proteins. High resolution, non invasive, optical methods are outstanding tools
that can provide us with unique insights into such sophisticated molecular
In this talk I will present a new optical experimental technique which is highly
sensitive and minimally invasive that allows, in particular, study of real time
dynamics of molecular motors in the single molecule limit. These dynamical
processes are essential to many cell functions, such as intracellular transport,
cell division, growth, and locomotion. The extremely high temporal (~10
microsecond) and spatial (subnanometer) resolutions provided by the new
method may be key to studying various interactions and dynamical mechanisms
of molecular motors. I will describe the basic physical principles of the
technique, and will discuss preliminary results from several systems, whose
detailed study is currently underway.
Please contact Prof. Carmen Menoni, [email protected], with any questions.