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Cardiac Catheterization Older Equipment Video camera or CCD Image intensifier Cine camera Cine film: Best spatial resolution Dynamic Digital: 60, 30, 15 frames/s Video tape: Only as a back-up due to poor spatial resolution Nonionic contrast: high iodine concentration (omnipaque 350) Patient table X-ray tube Modern equipment Charge Coupled Device (CCD) replace vidicon, or plumbicon tubes and Image Intensifiers Lightweight Fast movements Photoelectric detectors embedded in layers of silicon Each pixel is 6 to 25 microns in size, and can store 10,000 to 50,000 electrons. Pixels of a CCD arranged in a matrix. Each pixel corresponds to a pixel on a monitor Software: Diagnostic reporting aid that replaces the hand drawings of yesteryear. Superior vena cava Pulmonary valve AV node SA node Lt & Rt bundle branches (of HIS) Endocardium Myocardium Interventricular septum Pericardium Selected injection of the left coronary Artery: Cardiac Catheterization Coronary Arteries Left: Main CA Anterior descending: LAD (or anterior interventricular branch) Circumflex Diagonal branches Right: Main Posterior descending: PDA (or posterior interventricular branch) Marginal branch Perforating branches to myocardium Coronary Arteriography Rt coronary A RAO view Rt Marginal Branch Post. Descending A (PDA) (Post Interventricular A) LAO view Rt coronary A Rt Marginal Branch Post. Descending A (PDA) (Post Interventricular A) LAO view Lt coronary A Circumflex Branch of LCA Lt. Ant. Descending: LAD (Ant. interventricular branch) Diagonal Branches of LAD Lt coronary A Lt. Ant. Descending (LAD) RAO view Circumflex Branch of LCA Diagonal Branch of LAD Indications, Contraindications, and Risks for Cardiac Catheterization Angina (vs indigestion) Poor exercise tolerance Chest pain/pressure, left arm, jaw (or silent) MI from CAD Contraindications Cardiac or CAD Recent CVA Sepsis Risks bradycardia & hypotension PVCs V Tach V Fib Angiocardiography (Chambers and Valves) * Septal defects (PDA) * Valvular disease (Pulmonary valve stenosis casues increased pressure in Rt. vent) * Transposition of great vessels (Dextra cardia) * Tetralogy of Fallot 6 f pig for chambers, 40-60 cc of contrast Fetal Circulation Demonstrating the origins of patent ductus arteriosis (PDA) and patent foramen ovale Left Ventriculogram Calculating the ejection fraction of the left ventricle is accomplished by defining the edge of the ventricle wall during systole and diastole (top), by tracing the borders (bottom), and allowing the computer to do its work. Hemodynamics: Appendix B in Handbook of Radiologic Procedures With the catheter in place, and the manifold connected, accurate pressures can be taken within chambers or vessels through a device called a strain gauge R T P T QS Systole Diastole Hemodynamics: Appendix B in Handbook of Radiologic Procedures The Manifold and strain gauge transducer form a closed system Strain gauge transducer Contrast Heperinized Saline flush Waste fluid Systolic pressure measured through the catheter in the left ventricle. Manifold Syringe for hand injections of contrast and flushing catheter Pulmonary Wedge Pressures The right heart is accessed via puncture of the femoral vein. Following the normal blood flow, a partially inflated balloon aids in placement of the Swan-Ganz catheter tip in the pulmonary trunk, or pulmonary arteries. With the balloon fully inflated and wedged in the pulmonary trunk the pressure is the same as in the left atrium, (green arrows) which is otherwise difficult to access. Aorta Pulmonary arterioles, capillaries, & venules Vena Cava Pulmonary veins Pulmonary trunk Pulmonary Wedge Pressure In patient’s with no cardiac disease or pulmonary hypertension a wedge mean pressure of > 25 mm Hg indicates thrombus 40 mm Hg indicates 60% - 70% obstruction. Pressure wave forms superimposed on ECG Pulmonary wedge: mean < 12 mm Hg a R 10 c v 5 T P T QS Systole Diastole Pulmonary artery: mean 9-17 Systolic 15-30, Diastolic 4-14 20 Pressure in the right or left pulmonary arteries, though slightly higher, is similar to that in the trunk vessel. R 15 10 5 T mm Hg Systole P T QS Diastole Atrial Pressure Wave Forms superimposed on ECG Left Atrium: Mean 2-12 Same as pulmonary wedge Right Atrium: Mean 0-8 mm Hg 10 mm Hg R T c v 5 T P x Systole Diastole P T QS Ty QS Systole v c 5 10 a R a Diastole Summary of Measurements from the Atria and Pulmonary vessels Right Atrium: Mean 0-8 mm Hg Pulmonary wedge: mean 2-12 mm Hg R a 10 R 10 a v P T y x 5 T QS Systole Diastole mm Hg T Systole Diastole Pulmonary artery: mean 9-17 Systolic 15- 30, Diastolic 4-14 20 R a P QS Left Atrium: Mean 2-12 10 v c 5 T c v 10 5 P T QS Systole 5 T mm Hg Diastole The most notable difference is the right atrium’s mean of < 5 mm Hg, versus the pulmonary wedge and left artium pressures of < 12. R 15 c T As a generality the characteristics of the atria and pulmonary vessels are essentially the same. Systole P T QS Diastole The wedge and left atrium wave forms are differentiated by the phasic delay. Ventricular Pressure Wave Forms Characteristics of the right and left ventricles are similar, except the left is five to six times that of the right. Right Ventricle: Systolic 15-30, Diastolic 0-8 mm Hg 150 R Left Ventricle: Systolic 100-140, Diastolic 3-12 mm Hg 150 R 100 100 50 50 T P T QS Systole Diastole T P T QS Systole Diastole Left Ventricular Pressure Compared to the Aorta Left Ventricle: Systolic 100-140, Diastolic 3-12 Aorta: Systolic 100-140, Diastolic 60-90 mm Hg 150 mm Hg 150 R 100 100 50 50 T P T T QS Systole R P Dicrotic notch T QS Diastole Systole Diastole During ejection the pressure in the left atrium and aorta are the same up to the closure of the aortic valve (dicrotic notch). The pressure drop in the ventricle is dramatic after valve closure (<12), but remains high (<90) in the aorta. Coronary Artery Disease (CAD) CAD - stenosis from atherosclerosis causing ischemia. Leads to myocardial infarction (MI) and necrosis of the myocardium. Previous MIs are demonstated by impaired wall motion on angiocardiography. Most common form of heart disease and the leading cause of death in the United States. Primarily effects the right coronary, left coronary, and circumflex arteries. Typically the left coronary is dominant, which is why a high grade blockage of it has been dubbed the “widow maker.” Signs and Symptoms of CAD * * * * * * * Temporary chest pain (angina), SOB Nausea Weakness Diaphoresis Left arm, shoulder & upper abdomen pain Tightness and burning in chest Atherosclerotic disease of the: Has the sign of: Which may results in: Coronary artery Carotid artery Lower extremities Angina Transient ischemic attacks (TIA) Intermittent claudication myocardial infaction (MI) Cerebrovascular accident (CVA, stroke) Arteriosclerosis Obliterans Diagnostic Tests for CAD Blood tests Electrocardiogram (EKG) Echocardiography Exercise stress test Coronary angiography Myocardial perfusion imaging (nuclear) Electron-beam computed tomography (EBCT) Telemetry monitoring Prevention and treatment of CAD • Lifestyle changes • Statin drugs: Lipid (cholesterol) lowering • Calcium channel blockers: or nitrate drugs dilate arteries allowing more oxygenated blood to reach the myocardium • Beta blockers: control symptoms of angina by reducing the workload on the heart. • Coronary artery bypass graft (CABG), (not open heart) was first used in 1964. Veins, harvested from the leg (or internal mammary artery) are reversed and grafted from the aorta to the distal side of the blockage.