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EBOLA IN CONTEXT: UNDERSTANDING TRANSMISSION, RESPONSE AND CONTROL WEEK 1 STEP 1.9 THE LOGIC BEHIND ISOLATION: INCUBATION, LATENT AND INFECTIOUS PERIODS (VIDEO) This lecture introduces the key periods that are characteristics of infectious diseases: incubation, latent and infectious periods, and looks at how they interact to influence transmission. The incubation period is the time from acquiring the infection to the first symptoms of illness. The incubation period varies from person to person within a range that is characteristic for the disease. It may be shorter with a higher infecting dose. The latent period is the time from acquiring infection to the onset of infectiousness. The duration of the latent period is characteristic of particular infections. The infectious period is the time during which someone with an infection can transmit the infection to someone else. The degree of infectiousness varies through the infectious period. The length and relationship between the incubation, latent and infectious periods influence how infections spread. If the latent period is shorter than the incubation period, then individuals are infectious before they have symptoms. This can help the infection to spread more easily. If the latent period is longer than the incubation period, then people are infectious only after symptoms start. This means they can be recognised as being ill before they are infectious. For Ebola the incubation period is 2-21 days. The latent period is longer than the incubation period so people infected with Ebola are not infectious until after the symptoms have started. Infectiousness increases when the disease becomes more severe, and the bodies of people who die of Ebola are very infectious. The virus persists in the body fluids of survivors for a short period after recovery, and can persist in semen for up to three months. Complete the quiz in the next step and read this editorial to see if you think Kaci Hickox should have been quarantined. 1 This material has been repackaged from a free, online course delivered by the London School of Hygiene and Tropical Medicine on the FutureLearn platform in 2015. Additional information about the course and its contributors can be found on the School website. Future iterations of the course may feature slightly different material. Further live runs of this and other courses can be found on the platform. Please visit the School’s FutureLearn webpage for more details. Ebola in Context: Understanding Transmission, Response and Control by the London School of Hygiene & Tropical Medicine is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. 2