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Figure 8.19 Inhibition of enzyme activity A substrate can bind normally to the active site of an enzyme. Substrate Active site Enzyme (a) Normal binding A competitive inhibitor mimics the substrate, competing for the active site. A noncompetitive inhibitor binds to the enzyme away from the active site, altering the conformation of the enzyme so that its active site no longer functions. Competitive inhibitor (b) Competitive inhibition Noncompetitive inhibitor (c) Noncompetitive inhibition