Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Genetic code wikipedia , lookup
Basal metabolic rate wikipedia , lookup
Butyric acid wikipedia , lookup
Citric acid cycle wikipedia , lookup
Amino acid synthesis wikipedia , lookup
Biosynthesis wikipedia , lookup
Biochemistry wikipedia , lookup
Glyceroneogenesis wikipedia , lookup
Fatty acid synthesis wikipedia , lookup
Lecture 22 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964 <your question> Hormonal regulation The TCA The brain problem… Most energy stored as fatty acids Brain only uses Glc Fatty acids Glc? How does brain function during starvation? Production of ketone bodies Starvation Glycogen = 1 day Amino acids Glc. BUT… Muscles can use fatty acids (↓ need for Glc) Gluconeogenesis ↓ OAA, so ↓ TCA Without TCA, liver makes “Ketone bodies” from fats Ketone bodies Diabetes & ketone bodies Starvation ↑ KB Used by brain Extreme starvation Muscle breakdown No insulin ↑ Blood sugar, AND ↑ FA breakdown Too much Acetyl CoA ↑ Ketone bodies Brain has plenty of Glc! ↑ Ketone bodies in blood = ↓ pH ↑ Death If only… Making fatty acids = adding 2 Cs to chain! AcCoA Malonyl CoA ACP in FAS FAS FAS Fatty acid synthesis Substrate shuttling in FAS Substrate shuttling in FAS Further steps… Further steps… Regulation of FAS & breakdown Allosteric regulation of ACC