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Download Metabolism of the whole organism
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Metabolism of the whole organism • • • • • • • Metabolic profiles of organs Metabolic conditions Blood glucose levels: 90 mg/dL Fuel reserves glucose triacylglycerols proteins Metabolic homeostasis Metabolic profiles Brain • Nervous system: maintain membrane potentials • uses glucose (120g/day) • 60% of all glucose • blood levels of 84.7 = 1mM in brain • starvation use ketone bodies • Heart : uses fatty acids or ketone bodies Muscle • contraction • store glycogen • resting use fatty acid oxidation • active use glucose • starvation muscle broken down to alanine for gluconeogenesis Adipose Tissue • uses fatty acids for energy • exports fatty acids • glycerol exported out to the liver Liver & Kidney • Liver: provides fuel to other organs • gluconeogenesis, maintain blood glucose • store glycogen • export ketone bodies • uses keto acids for fuel • Kidney: needs energy for active transport • uses FA, KB, glucose, amino acids, • gluneogenic tissue Metabolic conditions • Controlled by hormones • insulin • glucagon • epinephrine • Normal regulation of blood glucose Insulin secretion Hormonal control Hormones Exercise • fuels during different levels of exercise • ATP production Starvation/Fasting • • • • Fuel mobilization after 3 day changes long term shifts hormonal changes Starvation profiles Fuel Modifications Liver modifications Diabetes • types of diabetes • changes in fuels • problems Insulin deficiency
