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Transcript
The Digestive System
19
Unit 1
Chapter 19
• Tube that includes: mouth, Pharynx,
Esophagus, Stomach, Small
intestine, Large intestine
• Accessory organs: teeth, tongue,
salivary glands, liver, gallbladder, and
pancreas
19
Unit 1
Gastrointestinal (GI) Tract
Figure 19.1
Overview- Operations
19
• Ingestion: eating
• Secretion: release of water, enzymes &
buffers
• Mixing & propulsion: movement along
GI tract
•
•
breakdown of foods
Absorption: getting it into the body
Defecation: dumping waste products =
defecation
Unit 1
• Digestion: mechanical and chemical
Wall Layers- Everywhere
19
• 4 layers
• Mucosa- epithelium, connective layer, glands,
muscularis mucosae
• Submucosa- connective tissue, blood vessels,
• Muscularis- circular layer, longitudinal layer
In mouth, pharynx & upper esophagus –skeletal muscle
Also in external anal sphincter
• Serosa or Visceral peritoneum
Unit 1
lymphatic vessels, enteric nervous system
Figure 19.2
Figure 19.3a
Figure 19.3b
Mouth
19
Unit 1
• Formed by cheeks, hard & soft palate &
tongue
• Soft palate at back includes a “hangy
down” part = uvula
• Tongue- muscular accessory organ
Salivary Glands
19
• 3 pairs of salivary glands
• Parotid• Submandibular-
• Saliva contains 99.5% water, salivary
amylase, mucus and other solutes
Unit 1
• Sublingual
Figure 19.4
Teeth
19
• Accessory organs in bony sockets of
mandible & maxilla
• 3 external regions:
• 3 layers of material
Enamel- covers crown
Dentin- majority of interior of tooth
Pulp cavity - nerve, blood vessel & lymphatics
Unit 1
Crown- above gums
Root- 1 or more parts embedded in socket
Neck – between crown and root near gum line
Figure 19.5
Digestion in the Mouth
19
maltose and larger fragments
Continues in the stomach until acidified
• Rounds up food into a soft bolus for
swallowing
Unit 1
• Mechanical breakdown- chewing
• Mixed with saliva by tongue
• Salivary amylase chemically breaks
down polysaccharides (starch)
Pharynx & Esophagus
19
• On swallowing:
• Bolus of food  oropharynx
• Laryngopharynx esophagus
Muscular contractions in pharynx help
Skeletal muscle –controls entry to esophagus
• Lower esophageal sphincter (LES)
Smooth muscle- regulates entry to stomach
Unit 1
• Upper esophageal sphincter (UES)
Figure 19.6a,b
Swallowing
19
Involuntary & breathing interrupted
Soft palate move up-close nasopharynx
Epiglottis seals off larynx
Bolus moves into esophagus through UES
• Esophageal stage peristalsis moves it
toward stomach
Unit 1
• Voluntary: bolus forced into oropharynx
• Triggers oropharyngeal stage
Figure 19.6c
Stomach
19
Cardia- surrounds upper opening
Fundus- superior & to left of cardia
Body – large central portion
Pylorus- lower part leading to pyloric sphincter
& duodenum
Unit 1
• J- shaped enlargement of tract
• Serves as mixing chamber and holding
reservoir
• Very elastic & muscular
• 4 regions
Figure 19.7
Stomach Wall
19
• Mucosa:
Folds called rugae
Epithelium- simple columnar mucous
Form gastric glands lining gastric pits
Chief cells inactive enzyme pepsinogen
Parietal cells HCl & intrinsic factor
Collectively = gastric juice
• Muscularis- 3 Layers: longitudinal,
circular & oblique
Unit 1
• Secretory cells: mucous neck cells
Figure 19.8
Figure 19.9
Digestion & Absorption
19
• Food entry stretch & rise in pH
• Pepsin digests protein peptides
• Little absorption- water, ions & some drugs
Unit 1
Nerve impulses  secretion & mixing waves
Food mixed with juice Chyme
Small amount pushed through pyloric sphincter
= gastric emptying- Carb. foods fastest, Entry
in duodenum feedback inhibition of stomach
activity
Pancreas
19
• Behind stomach-
Produces pancreatic juice
to duodenum via pancreatic duct
• NaHCO3 solution (pH 7.1-8.2)–
1000ml/day
Neutralize stomach acid and dilutes chyme
Proteases: chymotrypsinogen, trypsinogen, et. al.
Activated by entreokinase from intestine
Starch digesting- pancreatic amylase
Pancreatic lipase
Nucleotidases – RNAase & DNAase
Unit 1
• Pancreas- digestive enzymes
• Largest organ after the skin
• right below diaphragm
Bile   hepatic duct
• Gall bladder =Pear-shaped organ
on front (stores bile)
• cystic duct common bile duct
19
Unit 1
Liver & Gall Bladder
Bile
19
• Bicarbonate, bile salts & waste. – 1000
ml/day
• Important for emulsifying fats
• Pigment is bilirubin- from broken-down
heme during RBC recycling
• Bile salts reabsorbed at end of small
intestine- ileum
• recycle to liver in portal circulation
Unit 1
Increases surface area for digestion
Figure 19.10
Figure 19.11a
Figure 19.11b
Liver Function
19
• Maintains blood glucose
Stores as glycogen
Uses absorbed sugars & Converts amino
acids glucose
• Lipid metabolism
Excretion of bilirubin
Processes drugs and other chemicals
Store fat soluble vitamins
Make active vitamin D
Unit 1
•
•
•
•
Produces cholesterol & triglycerides, makes bile
Makes lipoproteins for lipid transport
• 3 parts: duodenum, jejunum, ileum
• Where most of the digestion occurs
• Essentially all of the nutrient
absorption
• Ends in ileocecal sphincter
19
Unit 1
Small Intestine
Figure 19.12a
Figure 19.12b
Wall Structure
19
• Same 4 layers
• Epithelial- simple columnar
Unit 1
Absorptive cells with microvilli
Goblet cells- secrete mucus
Wall Structure (Cont.)
19
Increase surface area for absorption
Include lacteals for lipid absorption
Unit 1
• Circular folds- increase surface area
• Villi- finger like projections of
mucosa
Figure 19.13
Motility & Secretions
19
• Secretions: alkaline, some enzymes
• Segmentation activity- for mixing
• Peristalsis for movement after most
absorption completed- slow waves
Unit 1
Water and salt to balance osmolality
~2000 ml/day
• Chyme enters with partially digested
carbohydrates & proteins
• Bile + pancreatic juice + intestinal
juice completes the job
• Absorption is of monosaccharides;
amino acids; phosphate sugar &
bases of DNA & RNA; fatty acids &
monoglycerides
19
Unit 1
Digestion & Absorption
Absorption
19
• By diffusion, facilitated diffusion, osmosis
& active transport
• Carbohydrates  monosaccharides
Via portal system to liver
Via portal system to liver
• Lipids reformed to triglycerides
Packaged in chlyomicrons with protein
Via lacteals  lymphatics
Unit 1
• Proteins (jejunum & ileum) amino
acids
Absorption (Cont.)
19
• Water & salt
Primarily osmotic movement along with
other nutrients
Fat soluble absorbed with fat
Water soluble with simple diffusion
B12 combines with intrinsic factor &
absorbed by active transport in ileum
Unit 1
• Vitamins:
Figure 19.14a
Figure 19.14b
Large Intestine
19
• Cecum, colon, rectum, anal canal
• Ileocecal canal large intestine
• Colon- ascending, transverse,
descending & sigmoid
•  rectum anal canal
Unit 1
Below is cecum with appendix
Figure 19.15a
Figure 19.15b
Figure 19.16
Digestion & Absorption
19
• Slow emptying of ileum
• Slow peristalsis
• Mass peristalsis with food in stomach
Moves from middle of colon  rectum
Unit 1
• Bacterial digestion