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The Leading Provider of Advanced Neurostimulation Products
Advanced Neurostimulation
The Magstim range of magnetic stimulation systems provide a variety of high quality solutions for
researchers and clinicians working within Neurology, Neuroscience, Psychiatry and Rehabilitation.
Magstim has substantial expertise in magnetic stimulation, and is a leader in the field, offering a wide
range of magnetic stimulators and stimulating coils to suit a variety of clinical and research
applications.
Non-invasive Neuromodulation
Magnetic stimulation is a non-invasive and painless method of stimulating human tissue using strong,
time varying magnetic fields to induce small currents in nerve tissue. These are able to stimulate
the human cortex, spinal roots and peripheral nerves.
Depending on the application a variety of output waveforms may be used to excite or inhibit nerve
response. These pulses can be either monophasic or biphasic, or a combination of the two.
This brochure is intended for users of TMS equipment outside of the USA.
a leader in the field of magnetic stimulation
Users of Magstim Transcranial Magnetic Stimulators in the USA please note:
Caution - Investigational Device. Federal (or United States law) limits device to investigational use.
Magstim
Magstim
Controlled
Trains
Magstim
2002
& BiStim2
- Monophasic
Monophasic
Systems
Magstimproduce
BiStim² offers
the potentialsystems;
to combine
two
Magstim
two monophasic
the Magstim
component
clinical
and research
assessment techniques,
Two
ISI optionsofoffer
maximum
controllability:
including:
● 1ms - 999ms in 1ms resolution
Triple
Stimulation
Technique
● ● 1.0ms
- 99.9ms
in 0.1ms
resolution
coil. The
ability
to changemonophasic
pulse intervals
and to systems
single
pulse
functionality,
waveform
● Resting Motor Threshold
BiStim² has the added advantage of being able to sum the
2
independently
power 2level
of each Magstim
Magstim
& the
BiStim
- Monophasic
are
favoured 200
for:control
● Active Motor Threshold
two single pulses provided by the Magstim 2002
Magstim
produce
monophasic
systems;
the Magstim2002
allows
fortwo
precise
sub- and
supra-threshold
●200²Neurological
research
● Central Conduction Time
stimulators to produce a single high power pulse equal to
and
BiStim2, which
are used
extensively
within the for
fields
of
and test
pulses.
Thisresearch
is invaluable
the
●conditioning
Cortical mapping
and
brain
● Motor Evoked Potential
neurology and neurophysiology. For accurate single pulse functionality, 113% of a single Magstim 200².
Inter-Cortical
and Intra-Cortical
●investigation
Functionalofassessment
of central
motor pathways
● Input-Output Curve
monophasic waveform systems are favoured for:
and Facilitation.
●Inhibition
Early diagnosis,
assessment and monitoring
● Cortical Silent Period
l Neurological research
of nervous diseases, such as Multiple
inter-stimulus
interval
(ISI) of the two pulses is
Magstim 200² offers complete flexibility and can be
lThe
Cortical
mapping and
brain research
Sclerosis and Motor Neurone Disease.
ladjustable
using either
integral
Functional assessment
of the
central
motorstimulator
pathways controls,
interfaced with a wide range of commercially available
lremote
Early diagnosis,
assessment
and
monitoring
of
nervous
diseases,
EMG systems. The monophasic waveform provides a high
Single control
pulsecoil or externally via triggering
such
as
Multiple
Sclerosis
and
Motor
Neurone
Disease.
software offering complete user flexibility.
degree of hemispheric accuracy, low noise and less coil
Magstim 200² provides users with the ability to elicit
heating
than other Trains
pulse waveforms.
Controlled
Single
pulsepotentials, quickly and easily, as a routine
cortical evoked
2
2
Magstim
offers the potential
to combine
Magstim
Magstim 200 provides users with the ability to elicit cortical
The
MagstimBiStim
200² is backward
compatible
with all two
Magstim
2
200 units to provide fully programmable paired pulse stimulation
evoked potentials, quickly and easily, as a routine component of clinical
stimulating coils.
Monophasic single pulse systems are favoured in neurological
Magstim
unitswhich
to provide
fullyextensively
programmable
2002
and 200²
BiStim2,
are used
within the
applications due to the accuracy of the stimulation and the low heat
paired
stimulation
through a single For
stimulating
fields
of pulse
neurology
and neurophysiology.
accurate
output.
through a single stimulating coil. The ability to change pulse intervals
and to independently control the power level of each Magstim 2002
allows for precise sub- and supra-threshold conditioning and test pulses.
This is invaluable for the investigation of Inter-Cortical and
Intra-Cortical Inhibition and Facilitation.
and research assessment techniques, including:
l
Triple Stimulation Techniquev
l
Resting Motor Threshold
l
Active Motor Threshold
l
Central Conduction Time
l Motor
Evoked Potential
l Input-Output
l Cortical
l Motor
a worldThemarket
leader in the field of
inter-stimulus interval (ISI) of the two pulses is adjustable using
either the integral stimulator controls, remote control coil or externally
magnetic stimulation
via triggering software offering complete user flexibility.
Curve
Two ISI options offer maximum controllability:
Silent Period
Mapping
l 1ms
- 999ms in 1ms resolution
- 99.9ms in 0.1ms resolution
l 1.0ms
Magstim 2002 offers complete flexibility and can be interfaced with
a wide range of commercially available EMG systems.The monophasic
waveform provides a high degree of hemispheric accuracy, low noise
and less coil heating than other pulse waveforms. The Magstim 2002 is
backward compatible with all Magstim stimulating coils, via the coil adaptor.
BiStim2 has the added advantages of being able to sum the two
single pulses provided by the Magstim 2002 stimulators to produce
a single high power pulse equal to 113% of a single Magstim 2002,
as well as having the functionality to connect two individual coils for
interhemispheric stimulation.
Magstim
200²
Magstim
BiStim²
Magstim
Rapid²
Magstim
Rapid² Plus¹
Monophasic
Monophasic
Twin Pulse
Biphasic
Biphasic
2.80kV
2.50kV*
1.67kV
1.67kV
2.0s
3.0s
4.0s
2.0s
3.0s
4.0s
Single PSU - 50Hz Dual PSU - 100Hz
Single PSU - 30Hz Dual PSU - 50Hz
Single PSU - 15Hz Dual PSU - 25Hz
100Hz
97Hz
41Hz
Minimum Inter Stimulus Interval
N/A
1.0ms
N/A
N/A
Minimum Inter Train Interval
N/A
4.0s
0.5s
0.5s
Maximum voltage
Maximum repetition rates
(230V configuration)
30%
50%
100%
“
* Also available as 2.80kV
“
Output Type
Magstim
Magstim 2002
& BiStim2 - Monophasic
Biphasic
Systems
Magstim
Rapid2 - Biphasic
2002 and BiStim2, which are used extensively within the
component of clinical and research assessment techniques,
including:
● Functional
assessmentviof- in
central
motor pathways
Cognitive
Neuroscience
the investigation
of learningvii viii,
ix
x
memory
, speech
, hearing,
visual, perception
and functional connection
● Early
diagnosis,
assessment
and monitoring
●withTriple
Stimulation
Technique
integral
system acquisition
software including latency and
●amplitude
Restingmeasurements.
Motor Threshold
The dedicated touch screen user interface
internal
and external
memory makes storage and retrieval
●withActive
Motor
Threshold
of
results
straightforward.
Connecting the optional thermal printer
● Central Conduction Time
allows for the provision of hard copies.
● Motor Evoked Potential
2
can be usedCurve
with other investigation tools such as fMRI, EMG,
●Rapid
Input-Output
EEG, tDCS, tACS and Image-guided TMS over a broad range of
● Cortical Silent Period
Magstim produce two monophasic systems; the Magstim
Magstim Rapid2 repetitive Transcranial Magnetic Stimulation (rTMS)
fields of neurology and neurophysiology. For accurate
devices are highly effective non-invasive biphasic magnetic stimulators
single pulse
functionality,
monophasic
waveform
designed
to meet
the exacting
needs of those
involvedsystems
at all levels of
are
favoured
for:
clinical and academic research. Highly efficient, short duration biphasic
pulses
makes it very well
suited to bilateral cortical stimulation and is
● Neurological
research
used
in
many
different
areas
of brain
research,
including:
● Cortical mapping and
research
of nervous xidiseases,
such as
Multiple
Psychiatry
- to influence
specific
brain function within the
Sclerosis and
Motorcortex
Neurone Disease.
dorsolateral
prefrontal
Neurophysiology - used in the stimulation of the peripheral
Single pulse
and central nerve pathways
Magstim 200² provides users with the ability to elicit
Rehabilitation - used in the promotion of muscle recovery
cortical
evoked
potentials,
and
the relief
of nerve
spasticityquickly and easily, as a routine
The Magstim Rapid2 range of repetitive stimulators has been
developed to maintain a consistent pulse amplitude/frequency during
the delivery of stimulation trains through Single Pulse, Repetitive, Burst
and Session modes of operation. Rapid2 stimulators offer frequencies
of up to 100Hz, with a 0.1Hz frequency resolution for the first 30Hz.
Magstim Rapid2 has a unique in built two channel EMG amplifier
protocols and is fully compatible with existing Magstim coils through
Magstim
200²
offers complete flexibility and can be
customised
hardware.
2
1
interfaced
with
a wide
range
of innovative
commercially
availableto the
Magstim Rapid
Plus
is an
enhancement
2
EMG
Theonly
monophasic
provides ahigher
high
Rapidsystems.
and is the
system ablewaveform
to offer a significantly
repetition
rate
at
stimulation
output
of
30%
and
higher.
This
degree of hemispheric accuracy, low noise and less coil is
particularly
applications
using protocols such as Theta Burstxii,
heating
thanuseful
otherinpulse
waveforms.
as the Magstim Rapid2 Plus1 is capable of up to 89% output at 50Hz.
The Magstim 200² is backward
compatible with all Magstim
With the addition of a Plus1 module a single PSU Rapid2 can be easily
stimulating
coils.
upgraded to dual PSU performance, whereas the addition of the Plus1
module to a dual PSU Rapid2 make high powered protocols feasible.
100
Rapid2 Plus1
90
Dual PSU Rapid2
80
Single PSU Rapid2
(230v configurations)
Frequency (Hz)
70
60
50
40
30
Magstim Rapid2 is for single pulse
and repetitive stimulation
20
10
0
0
10
20
30
40
50
60
70
80
90
100
80
90
100
Power (%)
Magstim Rapid2 Performance
100
90
80
Frequency (Hz)
70
60
50
40
30
20
“
10
0
0
10
20
30
40
50
60
Power (%)
Rapid2 Plus1
Dual PSU Rapid2
Single PSU Rapid2
70
Magstim
Magstim 2002 & BiStim2 - Monophasic
component of clinical and research assessment techniques,
Magstim produce two monophasic systems; the Magstim
including:
2002 and BiStim2, which are used extensively within the
fields of neurology and neurophysiology. For accurate
● Triple Stimulation Technique
single pulse functionality, monophasic waveform systems
● Resting Motor Threshold
are favoured for:
● Active Motor Threshold
● Neurological research
● Central Conduction Time
● Cortical mapping and brain research
● Motor Evoked Potential
● Functional assessment of central motor pathways
● Input-Output Curve
As
the original pioneers of TMS, Magstim are industry recognised
● Early diagnosis, assessment and monitoring
● Cortical Silent Period
as world leaders in diagnostic, research and therapy solutions.
of nervous diseases, such as Multiple
Magstim 200² offers complete flexibility and can be
rTMS (Repetitive
Transcranial
Sclerosis
and Motor Neurone
Disease. Magnetic Stimulation) is a treatment
interfaced with a wide range of commercially available
for patients that have not responded to pharmaceutical solutions - it is
EMG systems. The monophasic waveform provides a high
Single pulse
estimated
that up to 40% of patients do not benefit from, or cannot
degree of hemispheric accuracy, low noise and less coil
tolerate,
antidepressant
medications
– even after repeated
attempts.
Magstim 200²
provides users with
the ability to elicit
heating than other pulse waveforms.
evoked
potentials,
quickly that
and easily,
as ahas
routine
Acortical
recent
study
has shown
rTMS
a 58% response rate and
The Magstim 200² is backward compatible with all Magstim
37% remission rate and has shown efficacy as a well-tolerated
stimulating coils.
1
therapeutic option .
An effective treatment where
traditional medication has failed
Benefits of rTMS
● Treatment with rTMS has a fast onset of action with
significant patient improvement2
● Treatment is provided as an outpatient procedure
● Patients can return to normal activities
after treatment
● No anaesthesia or sedation required
● 20-30 treatments over 4-6 weeks
● 37.5 minute treatment time
Is rTMS right for you?
rTMS is a treatment that can be used as an adjunct with medication, or as a drug free treatment.
This therapy avoids the side effects associated with antidepressant medication.
rTMS is the future for depressed patients who are proving resistant to traditional
pharmaceutical solutions.
To request more information, please visit:
“
www.magstim.com/TMSclinical
email: [email protected] or Tel: +44 (0) 1994 240798
1 Carpenter. L, et al: Transcranial Magnetic Stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes
in clinical practice (2012)
2 Rossini. D, et al: Transcranial magnetic stimulation in treatment-resistant depressed patients: A double-blind, placebo-controlled trial (2005)
Magstim
Magstim 2002 & BiStim2 - Monophasic
Magstim produce two monophasic systems; the Magstim
Part
Coil
Description
2002 and BiStim2, which
are used
extensively
within the
No.
fields of neurology and neurophysiology. For accurate
single pulse functionality, monophasic waveform systems
are favoured for:
3192-00 90mm
Standard
Single
High Power
● Neurological research
Coil
Remote
● Cortical mapping and brain research
Control
● Functional assessment of central motor pathways
● Early diagnosis, assessment and monitoring
of nervous diseases, such as Multiple
9784-00 Disease.
90mm
Coil
Sclerosis and Motor Neurone
*
Single
High Power
Coil
1st generation
Single pulse
Magstim 200² provides users with the ability to elicit
cortical evoked potentials, quickly and easily, as a routine
1165-00
*
25mm
Double
Coil
Branding Iron
Polyurethane
1st generation
Stimulator Compatibility
Clearance
● Triple Stimulation Technique
● Resting Motor Threshold
Cortical
● Active Motor Threshold
Stimulation
● Central Conduction Time
Cervical
nerve ●
rootsMotor Evoked Potential
● Input-Output Curve
Lumbosacral
nerve ●
rootsCortical Silent Period
3
3
3
3
Magstim 200² offers complete flexibility and can be
Cortical
a wide range of commercially available
interfaced with
Stimulation
EMG systems. The monophasic waveform provides a high
Cervical
nerve degree
roots of hemispheric accuracy, low noise and less coil
Lumbosacral
heating than other pulse waveforms.
nerve roots
The Magstim 200² is backward compatible with all Magstim
stimulating coils.
Facial nerve
Median nerve
Ulnar nerve
Somatosensory
evoked potentials
F-Wave and
reflexes
3
3
3
3
3
3
3190-00 70mm
Double
Coil
Remote
Coil
Cortical
Stimulation
Spinal roots
Peripheral
nerves
3
3
3
3
3271-00
*
70mm
Double
Coil
Branding Iron
Polyurethane
1st generation
Cortical
Stimulation
Femoral nerve
Back and neck
3
3
3
3
3281-00
*
70mm Flat coil
Double Polyurethane
Coil
1st generation
Cortical
Stimulation
Femoral nerve
Back and neck
3
3
3
3
Please refer to www.magstim.com for regular product updates.
* Requires coil adapter
Regulatory
component of clinical and research assessment techniques,
2002 Bistim2 Rapid2 CE Mark
FDA
Application
including:
“
3
3
3
Magstim
Magstim 2002 & BiStim2 - Monophasic
Magstim produce two monophasic systems; the Magstim
Part
2002 and BiStim2, which
are usedCoil
extensivelyDescription
within the
No.
fields of neurology and neurophysiology. For accurate
single pulse functionality, monophasic waveform systems
are favoured for:
High
4102-00 D702
Performance
Double
● Neurological research
Double Coil
Coil
● Cortical mapping and brain research
● Functional assessment of central motor pathways
● Early diagnosis, assessment and monitoring
of nervous diseases, such as Multiple
Cone Coil
9902-00Disease.
110mm
Sclerosis and Motor Neurone
1st generation
*
Double
Coil
Single pulse
Magstim 200² provides users with the ability to elicit
cortical evoked potentials, quickly and easily, as a routine
4150-00 Alpha
70mm
Double
Coil
Alpha Coil
3530-00 70mm
Double
Coil
Air Cooled
Coil
3910-00 70mm
Double
Coil
3950-00 70mm
Double
Coil
(Placebo)
Stimulator Compatibility
● Triple Stimulation Technique
● Resting Motor Threshold
Cortical
● Active Motor Threshold
Stimulation
● Central Conduction Time
Spinal Roots
● Motor Evoked Potential
Peripheral
Nerves
● Input-Output Curve
● Cortical Silent Period
3
3
3
3
3
3
3
3
The Magstim 200² is backward compatible with all Magstim
stimulating coils.
Cortical
Stimulation
Spinal roots
Peripheral
nerves
3
3
3
3
Power intensive
protocols
Long duration
protocols
3
3
Air Film
Coil
Psychiatry
Cognitive
Neuroscience
Neurology
Neurophysiology
Rehabilitation
3
3
Identical to the
active coil (see
above) other than
the stimulating
output. Suitable
for double-blind
trials
Cortical
Stimulation
Cervical
nerve roots
Lumbosacral
nerve roots
3
3
“
FDA
Clearance
Magstim 200² offers complete flexibility and can be
Central motor
interfaced with a wide range of commercially available
disorders
EMG
systems. The monophasic waveform provides a high
Spinal
injuries
Urology
degree of hemispheric accuracy, low noise and less coil
heating than other pulse waveforms.
Please refer to www.magstim.com for regular product updates.
* Requires coil adapter
Regulatory
component of clinical and research assessment techniques,
Application
2002 Bistim2 Rapid2 CE Mark
including:
3
Magstim
Magstim 2002 & BiStim2 - Monophasic
Magstim produce two monophasic systems; the Magstim
2002 and BiStim2, which are used extensively within the
fields of
neurology and
neurophysiology. For accurate
Distributor
Information
single pulse functionality, monophasic waveform systems
are favoured for:
● Neurological research
● Cortical mapping and brain research
● Functional assessment of central motor pathways
● Early diagnosis, assessment and monitoring
of nervous diseases, such as Multiple
Sclerosis and Motor Neurone Disease.
Single pulse
Magstim 200² provides users with the ability to elicit
cortical evoked potentials, quickly and easily, as a routine
References
component of clinical and research assessment techniques,
including:
● Triple Stimulation Technique
● Resting Motor Threshold
● Active Motor Threshold
● Central Conduction Time
● Motor Evoked Potential
The Magstim
CompanyCurve
Ltd
● Input-Output
Spring
●Gardens,
CorticalWhitland
Silent Period
Carmarthenshire,
Magstim 200²SA34
offers0HR
complete flexibility and can be
Wales,
UK
interfaced
with a wide range of commercially available
T: +44
(0)1994
240798
EMG systems.
The monophasic waveform provides a high
E: [email protected]
degree of hemispheric accuracy, low noise and less coil
heating than other pulse waveforms.
www.magstim.com
The Magstim 200² is backward compatible with all Magstim
stimulating coils.
i Combining TMS
and fMRI: From 'virtual lesions' to
functional-network accounts of cognition.
Ruff CC, Driver J, Bestmann S.
Cortex. 2008 Dec 6. [Epub ahead of print]
ii Combining TMS and EEG to study cognitive function and
cortico-cortico interactions.
Taylor PC, Walsh V, Eimer M.
Behav Brain Res. 2008 Aug 22;191(2):141-7. Epub 2008 Apr 1.
iii Mapping of the human visual cortex using image-guided
transcranial magnetic stimulation.
Fernandez, E., Alfaro, A., Tormos, J.M., Climent, R., Martinez, M., Vilanova, H.,
Walsh, V., and Pascual-Leone, A.
Brain Research Protocols 10:115-124, 2002.
iv Complementary
localization and lateralization of orienting
and motor attention.
Rushworth, Matthew F.S., Ellison, Amanda, and Walsh, Vincent.
Nature Neuroscience, 4(6), June 2001.
v Triple
stimulation technique (TST) in amyotrophic lateral
sclerosis
Leonid Komissarow, Jens D. Rollnik, Dessislava Bogdanova, Klaus Krampfl, F.
A. Khabirov, Andon Kossev, Reinhard Dengler and Johannes Bufler
Clinical Neurophysiology, Volume 115, Issue 2, Pages 356-360
vi Transcranial
magnetic stimulation and cognitive
neuroscience
Vincent Walsh and Alan Cowey
Nature Reviews – Neuroscience, Volume 1, October 2000, 73-79
vii The Contribution of Primary Motor Cortex is Essential for
Probabilistic Implicit Sequence Learning: Evidence from Theta
Burst Magnetic Stimulation
Leonora Wilkinson, James T. Teo, Ignacio Obeso, John C. Rothwell and
Marjan Jahanshahi
Journal of Cognitive Neuroscience
viii Transcranial
magnetic stimulation can measure and
modulate learning and memory
J Grafman E Wassermann
Neuropsychologia 37 (1999) 159-167
ix Contribution
of noninvasive cortical stimulation to the study
of memory functions
A. Floela, L.G. Cohen
Brain Research Reviews 53 (2007) 250–259
x Stimulating
language: insights from TMS
Joseph T. Devlin and Kate E. Watkins
Brain 130, (2007) 610–622
xi Applications
of TMS to Therapy in Psychiatry.
Lisanby, Sarah H.; Kinnunen, Leann H.; Crupain, Michael J.
Journal of Clinical Neurophysiology. 19(4):344-360, August 2002.
xii Exploring Theta
Burst Stimulation as an intervention to
improve motor recovery in chronic stroke
P. Talelli, R. Greenwood, J. Rothwell
Clinical Neurophysiology, Volume 118, Issue 2, Pages 333-342
“
Users of Magstim Transcranial Magnetic Stimulators
in the USA please note:
Caution - Investigational Device. Federal (or United
States law) limits device to investigational use.
All standard products carry the
mark, comply with the Medical Device Directive
93/42/EEC, and are manufactured under a Quality System certified to ISO 13485.
© 2012 The Magstim Company Limited. Magstim®, and Air FilmTM are registered
trademarks of The Magstim Company Limited.
All specifications are subject to change. All material in this literature is produced in
good faith
This brochure is intended for users outside the USA