Download Book 1 - 33rd Annual Meeting of the European Section of the ISHR

from 1st to 4th of July 2015
in Bordeaux, France
33 meeting of the European
Section of ISHR
Preliminary program
rd
The organizing committee
The team in charge of logistic
Pierre Dos Santos: LIRYC Institute & CardioThoracic
Research Center of Bordeaux (UMR 1045 InsermUniversity of Bordeaux) & University Hospital of Bordeaux,
France
Rodolphe Fischmeister: President-Elect of the ISHRES - Signaling and Cardiac Pathophysiology (UMR-S 769
Inserm-University Paris Sud), France
David Eisner: President ISHR-ES - Manchester Academic
Health Science Centre, University of Manchester,
Manchester, UK
Peter Ferdinandy: Past-President of ISHR-ES
Department of pharmacology and pharmacotherapy,
Semmelweis University, Budapest, Hungary
Derek J Hausenloy: Secretary of the ISHR-ES - The Hatter
Cardiovascular Institute, University College of London, UK
Jolanda Van der Velden: Treasurer of the ISHR-ES
Laboratory for physiology, Institute for cardiovascular
research, VU University Medical Center, Amsterdam,
Netherlands
Thomas Eschenhagen: Department of Experimental
Pharmacology and Toxicology, University Medical Center
Hamburg-Eppendorf, Hamburg, Germany
Emilio Hirsch: Member of the ISHR-ES Council Department of Molecular Biotechnology and Health
Sciences, Center for Molecular Biotechnology, Torino, Italy
Michel Haïssaguerre: LIRYC Institute & CardioThoracic
Research Center of Bordeaux (UMR 1045 InsermUniversity of Bordeaux) & University Hospital of Bordeaux,
France
Pierre Jaïs: LIRYC Institute & CardioThoracic Research
Center of Bordeaux (UMR 1045 Inserm-University of
Bordeaux) & University Hospital of Bordeaux, France
Roger Marthan: LIRYC Institute & CardioThoracic
Research Center of Bordeaux (UMR 1045 InsermUniversity of Bordeaux) & University Hospital of Bordeaux,
France
Olivier Bernus: LIRYC Institute & CardioThoracic Research
Center of Bordeaux (UMR 1045 Inserm-University of
Bordeaux), France
Pierre Bordachar: LIRYC Institute & CardioThoracic
Research Center of Bordeaux (UMR 1045 InsermUniversity of Bordeaux) & University Hospital of Bordeaux,
France
Philippe Ritter: LIRYC Institute & University Hospital of
Bordeaux, France
Raymond Roudaut: University of Bordeaux & University
Hospital of Bordeaux, France
Thierry Couffinhal: Cardiovascular adaptation to
Ischemia (UMR 1024 Inserm-University of Bordeaux) &
University Hospital of Bordeaux, France
Cécile Duplàa: Cardiovascular adaptation to Ischemia
(UMR 1024 Inserm-University of Bordeaux), France
Pascale Dufourcq: Cardiovascular adaptation to Ischemia
(UMR 1024 Inserm-University of Bordeaux), France
Pierre-Alain Gadeau: Cardiovascular adaptation to
Ischemia (UMR 1024 Inserm-University of Bordeaux),
France
Fabrice Blanquie, Deputy head of administration in
charge of communication and institutional life, Security
and Defense Officier, University of Bordeaux
Norbert Loustaunau, Communication Manager,
Communications Direction, University of Bordeaux
Sandrine Micheneau, Audiovisuel Support Service
manager, Audiovisual and Multimedia Service, Logistic
Direction, PILPSE Pôle, University of Bordeaux
Céline Thouvenin, Event Manager, Congress & Events
Department, University of Bordeaux
Sophie Vialle, Communication Manager, LIRYC Institute,
Bordeaux
The contact
Danielle Pichereau-Le Ster, PTIB Manager
Campus Xavier Arnozan, Avenue du Haut-Lévêque 33604 Pessac - France
[email protected]
+33 (0)5.57.10.28.60
Partners
Photo credit
© Mairie de Bordeaux - Thomas Sanson - Château Olivier - Château
Pichon-Longueville
Welcome to Bordeaux,
World Capital of Wine
The 33rd Annual Meeting of the European Section of the ISHR will be held in Bordeaux from the 1st until
the 4th July 2015. It will be hosted by the University of Bordeaux (http://www.u-bordeaux.com). The University
of Bordeaux is the fifth largest university in France with 63,000 students, including 7,500 foreign students, 3,900
researchers and 110 research units. It contains several major national research centres including various laboratories
for major national centres (CNRS, INSERM, INRA, INRIA, IFREMER...). Ranked among the top universities in France, the
University of Bordeaux is renowned for the quality of its academic courses and research.
Cardiology, whether it concerns clinical care or research, is a field for which Bordeaux has long been an
internationally recognized site. The teams of clinicians and researchers have contributed to major scientific
developments in the fields of atrial fibrillation, ventricular fibrillation, cardiac resynchronization therapy for patients
suffering from heart failure and thrombosis. Such developments have led to therapeutic applications that have been
carried out throughout the world.
You will be received by the teams of the institute Liryc (http://www.ihu-liryc.fr), a multidisciplinary research,
clinical practice and training institute that is dedicated to understand electrical malfunctions of the heart.
This institute is one of a kind in Europe and gathers together on one platform a unique concentration of worldwide
renowned skills in the fields of cardiology, medical imagery, image analysis and modelling.
We have no doubt you will enjoy your stay in Bordeaux, the world capital of wine. 10,000 new inhabitants arrive
every year in this attractive city and has a UNESCO World Heritage classification. As well as participating in excellent
science, we hope you will take the opportunity to stroll through the streets of Bordeaux and appreciate its sights,
restaurants and cafes.
Rodolphe Fischmeister
President-Elect of the ISHR-ES
Pierre Dos Santos
President of the organizing committee
A world-renowned destination for its prestigious vineyards, Bordeaux is a beautiful city in
an outstanding region, with a habit of surprising its visitors …
Beyond the architectural and cultural heritage, Bordeaux has become an influential and
attractive metropolis.
• UNESCO World Heritage Site since 2007
• The world capital of wine
• 300 professional meetings per year
• One of the top french congress destination
• 4 million visitors per year
The wine-growing activities and the strong political and cultural links with the British Isles
have given Bordeaux an international flavour since the Middle Age!
General informations
Registration (Prices included taxes)
The registration to participate at the ISHR can only be done by internet. You can be connected from now
on the website ishr2015.com.
Registration fee to the Congress
ISHR non member
ISHR member
Students
Until 14th april 2015
400€
300€
100€
From the 15th april 2015
500€
400€
150€
The registration fee includes access to the Conference rooms and the rest of the Congress, the coffee
breaks, the lunches and the Gala dinner.
Registration fee for the social Program: 30€ ; 45€ for the accompanying person and 10€ for students.
Registration conditions and cancellation
Each registration will only be valid after the reception of the payment.
The closure date for the on-line registration is 29th May 2015. After that, the registration can be done
on the spot at the Congress with an increase of 15%.
Any cancellation must be done absolutely in writing (letter or fax) to Madame Danielle Pichereau Le Ster PTIB - Campus Xavier Arnozan - 33604 Pessac - France - Fax: (+33) 05 57 10 28 69
Before 29th May 2015, the Registration will be reimbursed minus 60€ of Administration fee (30€ for the
Students). After this deadline, it will not be possible to get any reimbursement.
Accomodation
For all accomodation requests, you can consult the site ishr2015.com in the item “Accomodation”: you will
find a list of Hotels and prices.
Internet site
Up to date Program, information, registration, submit of the abstracts on line on the website ishr2015.com
Place of the Congress
Université de Bordeaux - Campus Victoire
Place de la Victoire
33000 Bordeaux
Public transport
Tram: Line B - Victoire stop
Bus: Line 11 - 16 - 43 - 45 - Victoire stop
Meeting venue
Poster Display
15:30-17:00
Session 1 - Emerging Ca2+ channels in cardiovascular David J. Beech (Leeds, UK),
system
Marie Demion (Montpellier, France)
Stim 1 and Orai1 in cardiac hypertrophy
Jean-Sébastien Hulot (Paris, France)
Opening ceremony
Plenary session 1 - Outstanding Investigator Award lecture
microRNAs and the heart: what comes next? Thomas Thum (Hannover, Germany)
Orai1 channels in cardiac arrhythmias
TRPC in the heart
Jessica Sabourin (Châtenay-Malabry,
France)
Session 10 - Myocardial protection by remote ischemic Derek Yellon (London, UK)
pre-conditioning
Keith Garlid (Portland, USA)
Clinical application of RIPC
Hans Erik Bøtker (Aarhus, Denmark)
Confounders of cardioprotection by RIPC
17:00-18:00
18:00-19:30
Petra Kleinbongard (Essen, Germany)
Circulating nitrite during cardioprotection by RIPC
Tienush Rassaf (Düsseldorf, Germany)
Session 11 - Pathophysiology of heart failure with Jolanda van der Velden (Amsterdam,
preserved ejection fraction
The Netherlands)
Important players of diatolic dysfunction?
Nazha Hamdani (Amsterdam, The
Netherlands)
Titin-based stiffness in heart failure with preserved ejection Wolfgang Linke (Münster, Germany)
fraction: Novel regulatory mechanisms and therapeutic
implications
Collagen network
Javier Diez (Pamplona, Spain)
Coffee break and Posters
Session 2 - Calcium induced arrhythmias
David Eisner (Manchester, UK)
Donald M. Bers (Davis, USA)
Posttranslational modifications of ryanodine receptor
Ernst Niggli ( Bern, Switzerland)
Ca2+ handling in CPVT
Ana Maria Gomez (Châtenay-Malabry,
France)
Ultrastructural remodeling in CPVT
Session 9 - Inflammation in ischemia and reperfusion Peter
Ferdinandy
(Budapest,
injury revisited
Hungary), Stéphanie Barrère-Lemaire
(Montpellier, France)
The innate immune response in reperfused myocardium
Dominique P. V. de Kleijn (Utrecht, The
Netherlands & Singapore)
Molecular imaging of inflammation during ischemia and Robin P. Choudhury (Oxford, UK)
reperfusion using targeted microparticles
Monocytes and heart function after acute myocardial infarction Ziad Mallat (Paris, France & Cambridge,
UK)
Session 13 - Novel aspects of cell death and survival Metin Avkiran (London, UK),
mechanisms in heart failure
Lucie Carrier (Hambourg, Germany)
Autophagy, mitochondria and heart failure
Asa Gustafsson (San Diego, CA, USA)
Interplay between UPS and autophagy in the development of Tania Zaglia (Padova, Italy)
cardiomyopathies
Novel cAMP signalling in cardiac autophagy and apoptosis Frank Lezoualc’h (Toulouse, France)
during myocardial stress
Amphitheater Broca
Amphitheater Durkeim
Amphitheater E
Wednesday July, 1 st 2015
12:00
14:00-14:15
14:15-15:15
08:30
09:00-10:00
10:00-10:30
10:30-12:00
Poster Display
Cour d‘honneur
Plenary session 2 - Peter Harris Distinguished Scientists Award
Cell-Based Therapies for Ischemic Cardiomyopathy - Roberto Bolli (Louisville, KY, USA)
Coffee break
Atrium & Cour d’honneur
Session 3 - Electrophysiological and structural Michel Haïssaguerre (Bordeaux,
determinants of driver mechanisms in persistent AF: France), Yoram Etzion (Beer-Sheva,
insights from experimental models
Israel)
Rotors as drivers of atrial fibrillation
Jose Jalife (Ann Arbor, MI, USA)
Remodeling in atrial fibrillation
Epi-endocardial dissociation in persistent AF
Thursday July, 2 nd 2015
Session 8 - Looking beyond mitochondrial dynamics
12:00-13:30
13:30-15:00
Stéphane Hatem (Paris, France)
Ulrich Schotten (Maastricht, The
Netherlands)
Non-fusion effects of mitofusin 2 in the heart
Livia Hool (Western Australia), Jérémy
Fauconnier (Montpellier, France)
Gerald W. Dorn (St Louis, MO, USA)
Non-fusion effects of OPA1 in the heart
Luca Scorrano (Padova, Italy)
Mitochondrial-lysosomal axis in myocardial disease and aging
Session 12 - Extreme adrenergic stress and the heart Takotsubo cardiomyopathy and beyond
Myocardial responses to supraphysiological catecholamine
stimulation - differential effects of β1 and β2 signalling
Altered myocardial lipid metabolism after severe adrenergic
stress - Cause or effect?
Dolphins, diving and arrythmias: autonimic conflict as a trigger
for sudden death?
Lunch and Posters
Session 4 - Genetics of cardiac arrhythmias
Aleksei Terman (Linköping, Sweden)
Yoshihiko Saito (Nara, Japan),
Alexander Lyon (London, UK)
Sian E. Harding (London, UK)
In left ventricular hypertrophy
Session 14 - Pregnancy as a cardiac stress model
Torsten Doenst (Jena, Germany)
Masatsugu Hori (Osaka, Japan),
Constantinos Pantos (Athens, Greece)
Elmir Omerovic (Gothenburg, Sweden)
Michael J. Shattock (London, UK)
Atrium & Cour d’honneur
Pierre Jaïs (Bordeaux, France),
Pascale Guicheney (Paris, France)
Genetic aspects of arrhythmias
Jean-Jacques Schott (Nantes, France)
Targeted arrhytmia management
Andrew Grace (Cambridge, UK)
Modeling inherited arrhythmogenic syndromes with iPS
Oren Capsi (Haifa, Israel)
Session 6 - Subsarcolemmal vs interfibrillar mitochondria: Rainer Schulz (Germany),
Location, location, location!
Pierre Dos Santos (Bordeaux, France)
Differences in proteomics and function
Rainer Schulz (Germany)
In cardioprotection
Marisol Ruiz-Meana (Barcelona, Spain)
Physiological hypertrophy: Pregnancy and exercise, what is
the difference?
Pregnancy unmasks genetic cardiomyopathies
Protection against pregnancy induced cardiac stress: Role of
inter- and intra-cellular communication
Amphitheater Broca
Amphitheater Durkeim
Amphitheater E
Karin Y. van Spaendonck-Zwart
(Amsterdam, The Netherlands)
Denise Hilfiker-Kleiner (Hannover,
Germany)
15:00-16:30
16:30-18:00
Coffee break
Atrium & Cour d’honneur
Session 5 - New Insights into the mechanisms of Mélèze Hocini (Bordeaux, France)
ventricular fibrillation and defibrillation
Human ventricular fibrillation dynamics
Role of the Purkinje network in maintenance of ventricular Raymond E. Ideker (Birmingham,
fibrillation
Alabama, USA)
Low-energy defibrillation of ventricular fibrillation
Igor Efimov (St Louis, MO, USA)
Session 7 - Mitochondrial Ca transport & cardiac diseases Hossein Ardehali (Chicago, USA),
Rosario Rizzutto (Padova, Italy)
The mitochondrial Na+/Ca2+ exchanger and cardiac
arrhythmias
The mitochondrial calcium uniporter and the heart
Elizabeth Murphy (Columbia, MD, USA)
18:00-19:30
Michel Ovize (Lyon, France)
Keiichi Fukuda (Tokyo, Japan),
Michel Puceat (Marseille, France)
Clinical translation of pluripotent stem cell-based heart repair
Immunological considerations of stem cell-based heart repair Reem Al-Daccak (Paris, France)
Translating engineered heart muscle-based heart failure repair Wolfram H. Zimmermann (Göttingen,
Germany)
Plenary session 3 - Young investigator prize ceremony
Posters award ceremony & Award Servier
Presentation of ISSHR-ES Medal of Merit to Fabio di Lisa (Bologna, Italy)
Presentation of “Distinguished Leader Award” to David Hearse (London, UK)
Gala Dinner
Amphitheater Broca
Amphitheater Durkeim
Amphitheater E
Thursday July, 2 nd 2015
Endoplasmic reticulum, Ca2+ and mitochondria
Session 22 - Heart repair with pluripotent stem cells
8:30-9:00
09:00-10:00
Friday July, 3 rd 2015
10:00-10:30
10:30-12:00
12:00-13:30
13:30-15:00
Poster Display
Cour d’honneur
Plenary session 4 - Peter Harris Distinguished Scientists Award
X-ROS signaling in Heart - Jon Lederer (Maryland, USA)
Coffee break and Posters
Atrium & Cour d’honneur
Session 16 - Metabolic signalling pathways
Derek J Hausenloy (London, UK),
Fabio Di Lisa (Padova, Italy)
AMPK, a multifaceted target for therapeutic strategies against Luc Bertrand (Louvain, Belgium)
various heart diseases
Sirt1 and energy metabolism in normal and failing heart
Anne Garnier (Châtenay-Malabry,
France)
Adiponectin in heart failure
An M. Van Berendoncks (Antwerp,
Belgium)
Session 18 - Heart and cancer: Is the enemy of my enemy David Lefer (Atlanta, USA), Eric Morel
really my friend?
(Châtenay-Malabry, France)
Cardiac complications of thoracic radiotherapy
Marie Catherine Vozenin (Lausanne,
Switzerland)
Recent advances in understading to the mechanisms of Martin Sterba (Hradec Králové, Czech
anthracycline cardiotoxicity and links toward effective Republic)
cardioprotection
Targetting PI3K in the heart and in cancer
Emilio Hirsch (Torino, Italy)
Session 15 - Myocardial permeability, intersticial edema Cécile Duplàa (Bordeaux, France),
and cardiac function
Alain Lacampagne (Montpellier,
France)
Control of vascular integrity by endothelial cell junctions
Cardiac aquaporins
Arkadi Rutkovskiy (Oslo, Norway)
Myocardial edema: A translational view
David Garcia-Dorado (Barcelona, Spain)
Lunch and Posters
Atrium & Cour d’honneur honneur
Session 17 - Compartmentation of cardiac signaling
Lea M. Delbridge (Melbourne,
Australia), Rodolphe Fischmeister
(Châtenay-Malabry, France)
A-kinase anchoring proteins: molecular regulators of cardiac Dario Diviani (Lausanne, Switzerland)
remodeling
Real-time visualization of cyclic nucleotide signaling in Viacheslav O. Nikolaev (Hamburg,
cardiomyocytes
Germany)
Cyclic nucleotide signaling compartmentation in normal and Grégoire Vandecasteele (Châtenay
failing heart
Malabry, France)
Session 23 - Imaging the heart from within
Derek Hausenloy (London, UK),
Sean M Davidson (London, UK)
Superresolution meets physiology: EC coupling super-hubs in Stephan E. Lehnart (Göttingen,
atria
Germany)
Fluorescence imaging of cardiac mitochondria in ischaemia
Sean M Davidson (London, UK)
and reperfusion
Multimodality imaging of the adult murine heart
Daniel J. Stuckey (London, UK)
Session 21 - Joint SASCAR-ISHR-ES Session - Cardiovascular Thomas Eschenhagen (Hamburg,
biomaterials and regenerative medicine
Germany), Sandrine Lecour (Cape
Town, South Africa)
The fascinating journey of stem cell therapy for heart disease Massimiliano Gnecchi (Pavia, Italy)
Injectable biomaterials therapy for heart failure
Neil H. Davies (Cape Town, South Africa)
Engineered heart tissues for cardiac repair
Thomas Eschenhagen (Hamburg,
Germany)
Social event & Dinner
8:30-9:00
09:00-10:00
10:00-10:30
10:30-12:00
Poster Display
Cour d’honneur
Plenary session 5 - President’s Distinguished Lecture
Role of E3 ligase MG53 in metabolic syndrome and its cardiovascular complications Rui-Ping Xiao (China)
Coffee break and Posters
Atrium & Cour d’honneur
Session 25 - Gene therapy of cardiac diseases
Emilio Hirsch (Torino, Italy),
Finn Olav Levy (Oslo, Norway)
Gene therapy in hypertrophic cardiomyopathy
Lucie Carrier (Hamburg, Germany)
Gene therapy for arrhythmia control
Gene therapy in heart failure
Session 26 - Control of cardiac performance by sarcomere
proteins
Sarcomere mutations and energetic cost of cardiac contraction
Sarcomere active drugs in heart failure
12:00-13:30
13:30-15:00
Troponin I residues as molecular determinants of cardiac
myocyte performance
Session 19 - MicroRNAs for regenerative therapy of the
heart
microRNAs to direct cellular cardiac repair
Myocyte proliferation by microRNAs to enhance cardiac repair
microRNAs in cardiac regeneration
Lunch and Posters
Session 27 - Epigenetic control of cardiac remodeling
Alexander Lyon (London, UK)
Y. Zhu (China), Jean-Jacques Mercadier
(Châtenay-Malabry, France)
Jolanda van der Velden (Amsterdam, The
Netherlands)
Zoltan Papp (Debrecen, Hungary)
Joseph M. Metzger (Minneapolis, MN,
USA)
Manual Mayr (London, UK), Joost P. G.
Sluijter (Utrecht, The Netherlands)
Jean-Luc Balligand (Brussels, Belgium)
Mauro Giacca (Trieste, Italy)
Eva van Rooij (Utrecht, The Netherlands)
Atrium & Cour d’honneur honneur
Federica del Monte (Boston, MA, USA),
Kewal K. Talwar (New Delhi, India)
Amphitheater Broca
Amphitheater Durkeim
Amphitheater E
Saturday July, 4 th 2015
Histone deacetylase signaling in cardioprotection
Joahnnes Backs (Heidelberg, Germany)
Altered epigenetic profiles at enhancers and promoters during Roberto Papait (Rozzano, Italy)
cardiac hypertrophy
Epigenetics and noncoding RNAs in heart failure
Leon de Windt (Maastricht, The
Netherlands)
Session 24 - Sex differences in cardiovascular Renée Ventura-Clapier (Châtenaypathophysiology
Malabry, France), Jean-François Arnal
(Toulouse, France)
Sex-based differences in cardiovascular diseases
Jane-Lyse Samuel (Paris, France)
Sex and gender differences in pharmacotherapy
Vera Regitz-Zagrosek (Berlin, Germany)
Sex differences in excitation-contraction coupling
Susan E. Howlett (Halifax, Canada)
Session 20 - Circadian rhythms in cardiac repair: new Rui-Tai Hui (Beijing, China), Manuel
mechanisms for an old phenomenon
Galiñanes (Barcelona, Spain)
Circadian rhythms in cardiac regeneration: experimental basis Linda W. van Laake (Utrecht, The
for a clinical phenomenon
Netherlands)
Hematopoietic stem cell function is controlled by circadian
mechanisms
Angiogenesis is regulated by the circadian clock
Plenary session 6 - Closing session (optional)