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Probiotic for Oral and Immune Health FPO Support Healthy Bacteria in the Mouth for Breath and Immune Support The mouth is an entry point for pathogens as it comes into contact with billions of bacteria. If a healthy balance of oral bacteria is thrown off by stress, exposure to disease or antibiotics, it can quickly lead to problems such as bad breath, throat and ear infections. The microorganisms in our mouth are a first line of defense against pathogens and an important part of maintaining healthy oral bacteria. Streptococcus salivarius (S. salivarius) is one of the most numerous beneficial bacteria found in the mouth of healthy individuals. However, only a small percent of people have S. salivarius with BLIS K12 activity. The K12 strain was originally discovered as scientists tracked the oral bacteria of a healthy child that did not develop sore throats for several years. Scientists found that this particular K12 strain of S. salivarius secretes powerful antimicrobial molecules called BLIS: Bacteriocin-Like-Inhibitory Substances, with the ability to inhibit harmful bacteria such as the bacteria responsible for bad breath, sore throat and other upper respiratory infections. BLIS K12 is an advanced probiotic for the oral cavity (mouth) and upper respiratory tract. It is a specific strain of S. salivarius with actions to help provide a natural long-term breath support while boosting our immune system’s natural defenses. Why is BLIS K12 so unique? Most probiotic bacteria, including S. salivarius, compete with other microorganisms for space and nutrients in the oral cavity and in this way, act to maintain a healthy balance of oral bacteria. BLIS K12 works beyond competitive inhibition. It secretes two anti-microbial proteins called Salivaricin A and Salivaricin B which inhibit undesirable bacteria, making it more effective at fighting off pathogens.(5) When BLIS K12 enters the mouth, it attaches to cells in the oral cavity and colonizes.(6) By colonizing, BLIS K12 crowds out pathogenic bacteria, keeping them from adhering to the host. The final antibacterial punch comes from the production of BLIS molecules, Salivaricins A and B. Many potential pathogens are susceptible to these Salivaricins, including the bacteria that cause bad breath, sore throats, and those that cause upper respiratory tract and ear infections.(5) The Halitosis Issue Halitosis is the term given to bad breath. Studies have shown up to 50% of people can suffer from halitosis.(1) Like body odor, it is a major source of personal embarrassment and can severely affect social interactions. There are a number of factors that contribute to bad breath including metabolic disorders and poor diet choices, however the main source of bad breath is due to an imbalance of bacteria residing in the oral cavity. Odiferous species such as Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia grow uncontrollably and produce malodorous by-products, known as volatile sulfur com-pounds (VSCs) following metabolism of e.g. amino acids. These VSCs are the basis for experiencing bad breath. Advantages of Furthermore, studies have found halitosis sufferers have lower numbers of beneficial bacteria such as Streptococcus salivarius.(3) Therefore, reintroducing these bacteria addresses the root cause of bad breath. How does BLIS K12 Fight Bad Breath? Typically, sufferer’s attempt to “mask” the odor with cosmetic products such as mouth rinses, gums and sprays. Alternatively, various expensive and complicated treatments involve the short-term reduction of the malodorous bacteria (as well as good bacteria) from the mouth. However, their numbers soon return to previous levels without structurally solving the problem. • Activates in the mouth to support healthy balance of bacteria • Proprietary strain of bacteria with potent BLIS antibacterial molecules: Salivaricins A and B Using the S. salivarius K12 probiotic increases beneficial S. salivarius levels in the mouth as these microbes bind to human epithelial cells restoring a balance of beneficial non-malodorous bacteria.(2) Studies (Figure 1), have shown subsequent reduction in VSC levels from malodorous to more acceptable levels as a result of taking S. salivarius K12 products daily for 14 days.(4) Figure 2. Reduction of Oral Malodor 300 • Robust science with over 30 years’ research and an extensive collection of peer reviewed papers, articles and book chapters. • Safe and effective for children and adults • Supports our natural immune system defenses* • Promotes oral health • Supports healthy levels of beneficial microbes in the mouth • Helps colonize healthy oral microbes • Helps maintain long-term breath freshness* Sulfur Compounds (ppb) • Able to colonize and persist in the mouth 250 PRE-ppb 200 POST-ppb Offensive Breath Odor Marginal Breath Odor 150 100 50 0 Hydrogen Sulfide Methyl Mercaptan Methyl Disulfide Figure 1: Reduction of total measurable Volatile Sulfur Compounds (VSCs) (ppm) after 2 weeks dosing with S. salivarius BLIS K12. Bad breath is mainly caused by the breakdown of proteins on the tongue by certain bacteria, and the subsequent release of volatile sulfur compounds. BLIS K12 inhibits these bacteria and therefore targets the source of bad breath instead of just masking it. By promoting a healthy balance of bacteria in the oral cavity – BLIS K12 can help protect the gateway to our body’s health. BLIS K12™ is a specific strain of S. salivarius that has been shown in clinical trials and population-based studies to help provide a natural resistance to harmful bacteria such as S. Pyogenes, shown as a contributor to bacterial sore throats and ear infections.(1,7) BLIS K12 promotes healthy levels of beneficial oral microbes to support upper respiratory health and immune health.* Product Applications Ideal applications for BLIS K12 are those that allow prolonged contact with the mouth, such as: • Chewable tablets or lozenges • Fast-melt tablets • Powders • Yogurt • Ice cream • Chewing gum • Stick packs ABOUT STRATUM NUTRITION Stratum Nutrition is Empowering Product Innovation with functional and specialty ingredients for manufacturers and marketers of foods, beverages, and dietary supplements. Stratum offers a portfolio of branded, value-added ingredients that are progressive, safe and reliable. These ingredients are based on consumer need, supported by science and the backing of a trusted multi-national company. As a Novus International company, we support the Corporate Mission to make a clear difference in sustainably meeting the growing global needs for nutrition and health with a Vision to help feed the world affordable, wholesome food and achieve higher quality of life. References 1.US patent 6,773,912 B1 for S. Pyogenes. 2.Guglielmetti et al, Appl. Environ. Microbiol. 2010 June;76(12): 3948–58 3.Kazor et al. J. Clin. Microbiol. 2003. 41: 558–63. 4.Burton et al. J. Appl. Microbiol. 2006, 100(4):754-64. 5.Wescombe PA, Heng NC, Burton JP, Chilcott CN, Tagg JR. Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiol. 2009 Sep;4(7):819-35. 6.Burton et al. Probiotics & Antimicro Prot. 2010, 2(3):135-44. 7.Acquisition of S. pyogenes during eight month study of Dunedin, NZ school children. Screening S. salivarius population for BLIS producers in comparison of recurrent tonsillitis and otisis media. *These statements have not been evaluated by the Food & Drug Administration. Our products are not intended to diagnose, treat, prevent or cure any disease. To learn more information on our unique product portfolio, contact our sales team: [email protected] | Ph. 888.403.5039 | www.StratumNutrition.com Not all products are available in all countries. Stratum Nutrition • 20 Research Park Dr. • St. Charles, MO 63304 • 1.888.403.5039 • www.StratumNutrition.com NOTICE: While the information contained herein (“Information”) is presented in good faith and believed to be correct as of the date hereof, Novus Nutrition Brands, LLC (“NNB”) does not guarantee satisfactory results from reliance upon such Information, disclaims all liability for any loss or damage arising out of any use of this Information or the products to which said Information refers and MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE WITH RESPECT TO THE INFORMATION OR PRODUCTS, except as set forth in NNB’s standard conditions of sale. Nothing contained herein is to be construed as a recommendation to use any product or process in conflict with any patent, and NNB makes no representation or warranty, express or implied, that the use thereof will not infringe any patent. ® STRATUM NUTRITION is a trademark of Novus Nutrition Brands, LLC., and is registered in the United States and other countries. ™ BLIS K12 is a trademark of BLIS Technologies Limited. © 2012 Novus Nutrition Brands, LLC. All rights reserved. LIT3187_v1_EN_GLOBAL