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Probiotic for Oral and Immune Health
FPO
Support Healthy Bacteria in the Mouth
for Breath and Immune Support
The mouth is an entry point for pathogens as it comes into contact with billions of bacteria. If a healthy balance of oral
bacteria is thrown off by stress, exposure to disease or antibiotics, it can quickly lead to problems such as bad breath,
throat and ear infections. The microorganisms in our mouth are a first line of defense against pathogens and an important
part of maintaining healthy oral bacteria.
Streptococcus salivarius (S. salivarius) is one of the most numerous beneficial bacteria found in the mouth of healthy
individuals. However, only a small percent of people have S. salivarius with BLIS K12 activity. The K12 strain was originally
discovered as scientists tracked the oral bacteria of a healthy child that did not develop sore throats for several years.
Scientists found that this particular K12 strain of S. salivarius secretes powerful antimicrobial molecules called BLIS:
Bacteriocin-Like-Inhibitory Substances, with the ability to inhibit harmful bacteria such as the bacteria responsible for
bad breath, sore throat and other upper respiratory infections.
BLIS K12 is an advanced probiotic for the oral cavity (mouth) and upper respiratory tract. It is a specific strain of S. salivarius
with actions to help provide a natural long-term breath support while boosting our immune system’s natural defenses.
Why is BLIS K12 so unique?
Most probiotic bacteria, including S. salivarius, compete
with other microorganisms for space and nutrients in the
oral cavity and in this way, act to maintain a healthy balance
of oral bacteria. BLIS K12 works beyond competitive
inhibition. It secretes two anti-microbial proteins called
Salivaricin A and Salivaricin B which inhibit undesirable
bacteria, making it more effective at fighting off pathogens.(5)
When BLIS K12 enters the mouth, it attaches to cells in the
oral cavity and colonizes.(6) By colonizing, BLIS K12 crowds
out pathogenic bacteria, keeping them from adhering to
the host. The final antibacterial punch comes from the
production of BLIS molecules, Salivaricins A and B. Many
potential pathogens are susceptible to these Salivaricins,
including the bacteria that cause bad breath, sore throats,
and those that cause upper respiratory tract and ear
infections.(5)
The Halitosis Issue
Halitosis is the term given to bad breath. Studies have shown up to 50% of
people can suffer from halitosis.(1) Like body odor, it is a major source of
personal embarrassment and can severely affect social interactions.
There are a number of factors that contribute to bad breath including
metabolic disorders and poor diet choices, however the main source of bad
breath is due to an imbalance of bacteria residing in the oral cavity. Odiferous
species such as Porphyromonas gingivalis, Fusobacterium nucleatum and
Prevotella intermedia grow uncontrollably and produce malodorous by-products,
known as volatile sulfur com-pounds (VSCs) following metabolism of e.g.
amino acids. These VSCs are the basis for experiencing bad breath.
Advantages of
Furthermore, studies have found halitosis sufferers have lower numbers of
beneficial bacteria such as Streptococcus salivarius.(3) Therefore, reintroducing
these bacteria addresses the root cause of bad breath.
How does BLIS K12 Fight Bad Breath?
Typically, sufferer’s attempt to “mask” the odor with cosmetic products such as
mouth rinses, gums and sprays. Alternatively, various expensive and
complicated treatments involve the short-term reduction of the malodorous
bacteria (as well as good bacteria) from the mouth. However, their numbers
soon return to previous levels without structurally solving the problem.
• Activates in the mouth to support
healthy balance of bacteria
• Proprietary strain of bacteria with
potent BLIS antibacterial molecules:
Salivaricins A and B
Using the S. salivarius K12 probiotic increases beneficial S. salivarius levels in
the mouth as these microbes bind to human epithelial cells restoring a balance
of beneficial non-malodorous bacteria.(2) Studies (Figure 1), have shown
subsequent reduction in VSC levels from malodorous to more acceptable
levels as a result of taking S. salivarius K12 products daily for 14 days.(4)
Figure 2. Reduction of Oral Malodor
300
• Robust science with over 30 years’
research and an extensive collection of
peer reviewed papers, articles and
book chapters.
• Safe and effective for children and adults
• Supports our natural immune system
defenses*
• Promotes oral health
• Supports healthy levels of beneficial
microbes in the mouth
• Helps colonize healthy oral microbes
• Helps maintain long-term breath freshness*
Sulfur Compounds (ppb)
• Able to colonize and persist in the mouth
250
PRE-ppb
200
POST-ppb
Offensive Breath Odor
Marginal Breath Odor
150
100
50
0
Hydrogen
Sulfide
Methyl
Mercaptan
Methyl
Disulfide
Figure 1: Reduction of total measurable Volatile Sulfur Compounds (VSCs) (ppm) after 2 weeks
dosing with S. salivarius BLIS K12.
Bad breath is mainly caused by the breakdown of proteins on the tongue by
certain bacteria, and the subsequent release of volatile sulfur compounds.
BLIS K12 inhibits these bacteria and therefore targets the source of bad breath
instead of just masking it.
By promoting a healthy balance of bacteria in the oral cavity –
BLIS K12 can help protect the gateway to our body’s health.
BLIS K12™ is a specific strain of S. salivarius that has been
shown in clinical trials and population-based studies to help
provide a natural resistance to harmful bacteria such as S.
Pyogenes, shown as a contributor to bacterial sore throats and
ear infections.(1,7) BLIS K12 promotes healthy levels of beneficial
oral microbes to support upper respiratory health and immune
health.*
Product Applications
Ideal applications for BLIS K12 are those that allow prolonged
contact with the mouth, such as:
• Chewable tablets or
lozenges
• Fast-melt tablets
• Powders
• Yogurt
• Ice cream
• Chewing gum
• Stick packs
ABOUT STRATUM NUTRITION
Stratum Nutrition is Empowering Product Innovation with
functional and specialty ingredients for manufacturers and
marketers of foods, beverages, and dietary supplements.
Stratum offers a portfolio of branded, value-added ingredients
that are progressive, safe and reliable. These ingredients are
based on consumer need, supported by science and the
backing of a trusted multi-national company.
As a Novus International company, we support the Corporate
Mission to make a clear difference in sustainably meeting the
growing global needs for nutrition and health with a Vision to
help feed the world affordable, wholesome food and achieve
higher quality of life.
References
1.US patent 6,773,912 B1 for S. Pyogenes.
2.Guglielmetti et al, Appl. Environ. Microbiol. 2010 June;76(12): 3948–58
3.Kazor et al. J. Clin. Microbiol. 2003. 41: 558–63.
4.Burton et al. J. Appl. Microbiol. 2006, 100(4):754-64.
5.Wescombe PA, Heng NC, Burton JP, Chilcott CN, Tagg JR. Streptococcal bacteriocins
and the case for Streptococcus salivarius as model oral probiotics. Future Microbiol.
2009 Sep;4(7):819-35.
6.Burton et al. Probiotics & Antimicro Prot. 2010, 2(3):135-44.
7.Acquisition of S. pyogenes during eight month study of Dunedin, NZ school children.
Screening S. salivarius population for BLIS producers in comparison of recurrent
tonsillitis and otisis media.
*These statements have not been evaluated by the Food & Drug Administration.
Our products are not intended to diagnose, treat, prevent or cure any disease.
To learn more information on our unique product portfolio, contact our sales team: [email protected] | Ph. 888.403.5039 | www.StratumNutrition.com
Not all products are available in all countries.
Stratum Nutrition • 20 Research Park Dr. • St. Charles, MO 63304 • 1.888.403.5039 • www.StratumNutrition.com
NOTICE: While the information contained herein (“Information”) is presented in good faith and believed to be correct as of the date hereof, Novus Nutrition Brands, LLC (“NNB”) does not guarantee
satisfactory results from reliance upon such Information, disclaims all liability for any loss or damage arising out of any use of this Information or the products to which said Information refers and MAKES
NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE WITH RESPECT TO THE
INFORMATION OR PRODUCTS, except as set forth in NNB’s standard conditions of sale. Nothing contained herein is to be construed as a recommendation to use any product or process in conflict with
any patent, and NNB makes no representation or warranty, express or implied, that the use thereof will not infringe any patent.
® STRATUM NUTRITION is a trademark of Novus Nutrition Brands, LLC., and is registered in the United States and other countries.
™ BLIS K12 is a trademark of BLIS Technologies Limited.
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