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Transcript
Department of Pathology 2016 Seminar Programme Presents: Amarni Thomas and Luke Henderson Friday 5th August 2016 D’Ath Lecture Theatre, Hercus Building Amarni Thomas: Transcrip/onal regula/on of the Runx1 gene The developmental transcription factor RUNX1/AML1 is a well-known leukaemia-associated gene. Runx1 is an important regulator of definitive haematopoiesis in vertebrates; it is crucial for early myeloid differentiation, and plays a vital role in adult haematopoiesis. Although RUNX1 is frequently translocated or mutated in AML, 25 % of patients do not have a disruption in known AML genes. We hypothesise that in cases where no mutation or translocation is found in the coding sequence of RUNX1, there may be mutations in non-coding regulatory sequences that affect gene expression. This PhD project aims to provide insight into the elaborate orchestration of Runx1 regulation, as well as reveal the genetic roles of RUNX1 and cis-regulatory elements in AML development. Luke Henderson: Melanoma and the regula/on of the p53 pathway" The developmental transcription factor RUNX1/AML1 is a well-known leukaemia-associated gene. Runx1 is an important regulator of definitive haematopoiesis in vertebrates; it is crucial for early myeloid differentiation, and plays a vital role in adult haematopoiesis. Although RUNX1 is frequently translocated or mutated in AML, 25 % of patients do not have a disruption in known AML genes. We hypothesise that in cases where no mutation or translocation is found in the coding sequence of RUNX1, there may be mutations in non-coding regulatory sequences that affect gene expression. This PhD project aims to provide insight into the elaborate orchestration of Runx1 regulation, as well as reveal the genetic roles of RUNX1 and cis-regulatory elements in AML development. Proudly sponsored by