Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
SANJIB GOGOI, Ph.D. Residential Address Scientist apt. 8, NEIST, Jorhat-785006 Assam Ph: 7896747138 [email protected] Departmental Address Medicinal chemistry division NEIST, Jorhat-785006 Assam PERSONAL PROFILE Date of Birth: 03rd March, 1976 Sex: Male Languages Known: English, Hindi and Assamese Nationality: Indian Marital Status: Married EDUCATION 2003-2008 Ph. D., Organic Chemistry National Chemical laboratory, Pune, India (Pune University) Thesis title: “Studies on total synthesis of bioactive natural butyrolactones” Advisor: Dr. N. P. Argade (Senior Scientist) 1999-2001 M. Sc., Organic Chemistry First Class (75.5%), Department of Chemistry, Dibrugarh University, Dibrugarh, Assam, India 1994-1998 B. Sc., Chemistry (Ancillary subjects: Mathematics & Physics) First Class (64.5%), DHSK College (Dibrugarh University), Dibrugarh, Assam, India PROFESSIONAL EXPERIENCE 2009-2011 Postdoctoral Fellow, Wayne State University, Detroit, Michigan, USA Advisor: Dr. Aloke K. Dutta Design and synthesis of dopamine receptor agonists that have been used frequently in the therapy of Parkinson’s disease, which is an age-related progressive, chronic neurodegeneration disorder and is characterized by gradual loss of dopamine producing cells in the brain Design and synthesis of blockers for serotonin transporter (SERT), norepinephrine transporters (NET) and dopamine transporter (DAT) for the treatment of depression Completed design, synthesis of multi-functional pro-drug derived from novel dopamine agonist, and in vitro/vivo studies of this prodrug for symptomatic and neuroprotective therapy for Parkinson’s disease Completed design, synthesis and in vitro/vivo studies of multifunctional 4-(4-(2-((2-amino4,5,6,7-tetrahydrobenzo[d]-thiazol-6yl)(propyl)amino)ethyl)piperazine-1-yl)quinoline-8-ol and its analogues which are found to be highly potent dopamine D2/D3 agonist SANJIB GOGOI, Ph.D. Page 2 Completed design, synthesis and in vitro/vivo studies of analogues of 4-((((3S,6S)-6benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenols, which are found to be triple uptake inhibitory activity and useful as potential antidepressant agents 2008-2009 2005-2007 2003-2004 Postdoctoral Researcher, University of Texas at San Antonio, San Antonio, Texas, USA Advisor: Dr. Cong-Gui Zhao Development of new methodology to synthesize bioactive molecules using organocatalyst Completed highly enantioselective synthesis of β-(3-hydroxypyrazol-1-yl) ketones using an organocatalyzed Michael addition reaction Completed enantioselective synthesis of aldol adducts using modularly designed organocatalytic assemblies of organocatalyst Completed organocatalyzed enantioselective synthesis of 6-amino-5cyanodihydropyrano[2,3-c]pyrazoles Senior Research Fellow, National Chemical Laboratory, Pune, India Advisor: Dr. N. P. Argade Completed the first synthesis of germination inhibitor (+)-erigeronic acid and its analogous Completed the synthesis of plant growth regulator (–)-saccharinic acid lactone and leaf closing compound potassium (2R,3R)-2,3,4-trihydroxy-2-methylbutanoate by using enzyme Amano PS Completed the synthesis of pandanus alkaloid (±)-Norpandamarilactonines A-B, (±)Pandamarilactonines A-D and Pandanamine Junior Research Fellow, National Chemical Laboratory, Pune, India Advisor: Dr. N. P. Argade Completed first synthesis of leaf-closing compound (±)-erythro potassium 2,3,4-trihydroxy2-methyl-butanoate Completed the synthesis of marine anti-fouling agents maculalactones A-C and cytotoxic nostoclide I Completed the first synthesis of cytotoxic ellipsoidone A and B OTHER EXPERIENCE AND TECHNICAL SKILLS Worked for eight months (2002), as project assistant (isolation of natural product) at Regional Research Laboratory (CSIR), Jorhat, Assam, India Worked as a chemist for three months (2002), in Dr. Reddy’s Laboratory, one of the leading pharmaceutical industry in India Experience in design and synthesis of a variety of biologically active natural products and synthetic molecules and expertise in multistep synthesis Experience with purification and separation techniques pertinent to synthetic organic chemistry Expertise in analysis of compounds by NMR, MS, FTIR, and UV Expertise in operating NMR, UV-Vis spectroscopy, analytical/semi-preparative HPLC, HPLC with EC detector Experience in working Molecular Modeling Softwares like Sybyl, MOE on linux red hat Profound efficiency in handling of hygroscopic, air sensitive reagents and reactions Identification of research problems and resolving them independently Capable of performing collaborative as well as independent research SANJIB GOGOI, Ph.D. Page 3 Familiar with Microsoft Office, Chem. Draw, ISIS Draw, Versamax, Rotomax etc Excellent communication and presentation skills in both oral and written form An easy going and friendly interpersonal relationship Experience in cell culture techniques Adept at maintaining cell lines including N-27, SH-SY5Y Experience in performing in vivo pharmacological assays including animal model of Parkinson’s disease using 6-hydroxy dopamine treated unilaterally lesioned rats, locomotor activity test using animal activity monitor (Versamax), forced swim test and tail suspension test to evaluate the antidepressant activity of a compound Experience in performing biochemical colorimetric assays to evaluate the antioxidant property of a compound Experience in performing cytotoxicity assay (MTT assay) to evaluate the toxicity as well as the neuroprotective efficacy of a compound upon treatment with known neurotoxic agent on N-27 and SH-SY5Y cell lines AWARDS AND HONORS Senior Research Fellowship (SRF), Council of Scientific and Industrial Research (CSIR), Government of India, India (2004-2007) Junior Research Fellowship (JRF), Council of Scientific and Industrial Research (CSIR), Government of India, India (2003-2004) Ranked first in M.Sc.(Organic Chemistry) of 1999-2001, Dibrugarh University, Assam, India RESEARCH INTERESTS Medicinal Chemistry, mainly to discover novel drugs for the CNS to explore their potential therapeutic application in several neuro-disorders like Parkinsonís disease (PD), depression and drug addiction Total synthesis of bioactive natural products and natural product hybrids Development of novel organocatalysts for enantioselective reactions Combinatorial chemistry and drug design Chemoenzymatic preparation of important chiral compounds & intermediates and also the development of enzymes as reagents for effecting organic transformations PROFESSIONAL SOCIETIES Member, American Association of Pharmaceutical Scientist (AAPS) POSTER/ORAL PRESENTATION Poster presented in 40th Neuroscience, SfN's 40th annual meeting, San Diego, CA, USA Nov. 13-17, 2010 Poster presented in 237th ACS National Meeting, Salt Lake City, UT, USA, March 22-26, 2009 Poster presented in the Science Day Celebration at National Chemical Laboratory, Pune, India during February, 2007 SANJIB GOGOI, Ph.D. Page 4 Oral presentation of Ph. D. work in Junior National Organic Symposium Trust (JNOST) held at International girls college, Jaipur, India during October, 2006 Poster presented in the Ramanbhi foundation 2nd international symposium on “Current Trends in Pharmaceutical Sciences” held at Zydus Research Centre, Ahmedabad, India during January, 2005 PEER REVIEWED PUBLICATIONS 1. Synthesis of potassium 2,3,4-trihydroxy-2-methylbutanoate: a leaf-closing substance of Leucaena leucocephalam Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2004, 60, 9093. 2. Synthesis of naturally occurring bioactive butyrolactones: maculalactones A–C and nostoclide I Anirban Kar, Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2005, 61, 5297. 3. A facile chemoenzymatic approach to natural cytotoxic ellipsoidone A and natural ellipsoidone B Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2006, 62, 2715. 4. A facile two-step chemoenzymatic access to natural germination inhibitor (+)-erigeronic acid A Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2006, 62, 2999. 5. An efficient Amano PS-catalyzed chemo-, regio- and enantioselective hydrolysis of (±)-2,3di-O-acetyl-2-C-methyl-D-erythrono-1,4-lactone: a facile preparation of bioactive natural products (–)-saccharinic acid lactone and potassium (2R,3R)-2,3,4-trihydroxy-2- methylbutanoate Sanjib Gogoi and Narshinha P. Argade* Tetrahedron: Asymmetry 2006, 17, 927. 6. Synthesis of norpandamarilactonines, pandamarilactonines and pandanamine Sanjib Gogoi and Narshinha P. Argade* Synthesis 2008, 1455. 7. Enantioselective Synthesis of -(3-Hydroxypyrazol-1-yl) Ketones Using an Organocatalyzed Michael Addition Reaction Sanjib Gogoi, Cong-Gui, Zhao,* Derong, Ding Organic Letters 2009, 11(11), 2249. 8. Organocatalyzed enantioselective synthesis of 6-amino-5-cyanodihydropyrano[2,3- c]pyrazoles Sanjib Gogoi, Cong-Gui Zhao* Tetrahedron Letters 2009, 50(19), 2252. 9. Dopamine D2/D3 agonist with potent iron chelation and antioxidant properties: Potential implication in symptomatic and neuroprotective treatment of Parkinson’s disease SANJIB GOGOI, Ph.D. Page 5 Sanjib Gogoi, Tamara Antonio, Maarten Reith and Aloke Dutta* Chem. Med. Chem 2011, 6, 991. 10. Development of an efficient asymmetric synthetic route to a novel triple uptake inhibitor antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran4-ol (D-142). Bhaskar Gopishetty, Sanjib Gogoi, Aloke Dutta* Tetrahedron: asymmetry 2011, 22, 1081. 11. The novel trisubstituted pyran derivative D-142 with triple monoamine reuptake inhibitory activity: potent antidepressant-like activity from animal models of depression studies. Aloke Dutta,* Bhaskar Gopishetty, Sanjib Gogoi, Solav Ali, Juan Zhen, Maarten Reith Eur. J. Pharmacol. 2011, 671, 39. 12. Facile ultrasound-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione fused steroidal derivatives by a three-component reaction Mandakini Dutta, Junali Gogoi, Kommoori Shekarrao, Jonalee Goswami, Sanjib Gogoi* and Romesh Chandra Boruah* Synthesis 2012, 44, 2614-2622. 13. A microwave promoted solvent-free approach to steroidal quinolines and their in-vitro evaluation for antimicrobial activities Shyamalee Gogoi, Kommuri Shekarrao, Aparajita Duarah, Tarun C Bora, Sanjib Gogoi, Romesh C Boruah* Steroids 2012, 77, 1438-45. 14. (3S,6S)-6-Benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants. Santra, Soumava; Gogoi, Sanjib; Gopishetty, Bhaskar; Antonio, Tamara; Zhen, Juan; Reith, Maarten E. A.; Aloke K. Dutta, Chem. Med. Chem. 2012, 7, 2093-2100. 15. Asymmetric Aldol reaction catalyzed by modularly designed organocatalysts. Sinha debarshi, Mandal Tanmay, Gogoi Sanjib, Goldman Joshua, Zhao, Cong-Gui Chin. J. Chem. 2012, 30, 2624-2630. 16. Novel bivalent ligands for D2/D3 dopamine receptors: significant cooperative gain in D2 affinity and potency. Sanjib Gogoi, Swati Biswas, Modi Gyan, Antonio Tamara, Maarten E Reith, Aloke K Dutta ACS Med. Chem. Lett. 2012, 3, 991-996 17. A rapid and convenient synthesis of 3, 5 disubstituted 2-chloropyridines and tetrazolo[1,5a]pyridines under microwave irradiation Shyamalee Gogoi, Sanjib Gogoi, Romesh C Boruah Synthesis 2013, 45, 219-24. SANJIB GOGOI, Ph.D. Page 6 18. Microwave-promoted and Lewis acid catalysed synthesis of steroidal A- and D-ring fused 4,6-diarylpyridines. Mandakini Dutta, Pallabi Saikia, Sanjib Gogoi*, Romesh C. Boruah*. Steroids 2013, 78, 387-395. 19. Palladium-catalyzed multi-component synthesis of steroidal A- and D-ring fused 5,6disubstituted pyridines under microwave irradiation. Kommuri Shekarrao, Dipankar Nath, Partha Pratim Kaishap, Sanjib Gogoi,* Romesh C Boruah*. Steroids 2013, http://dx.doi.org/10.1016/j.steroids.2013.08.002.