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SANJIB GOGOI, Ph.D.
Residential Address
Scientist apt. 8,
NEIST, Jorhat-785006
Assam
Ph: 7896747138
[email protected]
Departmental Address
Medicinal chemistry division
NEIST, Jorhat-785006
Assam
PERSONAL PROFILE
Date of Birth: 03rd March, 1976
Sex: Male
Languages Known: English, Hindi and Assamese
Nationality: Indian
Marital Status: Married
EDUCATION
2003-2008
Ph. D., Organic Chemistry
National Chemical laboratory, Pune, India (Pune University)
Thesis title: “Studies on total synthesis of bioactive natural butyrolactones”
Advisor: Dr. N. P. Argade (Senior Scientist)
1999-2001
M. Sc., Organic Chemistry
First Class (75.5%), Department of Chemistry, Dibrugarh University,
Dibrugarh, Assam, India
1994-1998
B. Sc., Chemistry (Ancillary subjects: Mathematics & Physics)
First Class (64.5%), DHSK College (Dibrugarh University),
Dibrugarh, Assam, India
PROFESSIONAL EXPERIENCE
2009-2011
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Postdoctoral Fellow, Wayne State University, Detroit, Michigan, USA
Advisor: Dr. Aloke K. Dutta
Design and synthesis of dopamine receptor agonists that have been used frequently in the
therapy of Parkinson’s disease, which is an age-related progressive, chronic
neurodegeneration disorder and is characterized by gradual loss of dopamine producing
cells in the brain
Design and synthesis of blockers for serotonin transporter (SERT), norepinephrine
transporters (NET) and dopamine transporter (DAT) for the treatment of depression
Completed design, synthesis of multi-functional pro-drug derived from novel dopamine
agonist, and in vitro/vivo studies of this prodrug for symptomatic and neuroprotective
therapy for Parkinson’s disease
Completed design, synthesis and in vitro/vivo studies of multifunctional 4-(4-(2-((2-amino4,5,6,7-tetrahydrobenzo[d]-thiazol-6yl)(propyl)amino)ethyl)piperazine-1-yl)quinoline-8-ol
and its analogues which are found to be highly potent dopamine D2/D3 agonist
SANJIB GOGOI, Ph.D.
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 Completed design, synthesis and in vitro/vivo studies of analogues of 4-((((3S,6S)-6benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenols, which are found to be triple
uptake inhibitory activity and useful as potential antidepressant agents
2008-2009
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2005-2007
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2003-2004
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Postdoctoral Researcher, University of Texas at San Antonio, San Antonio, Texas, USA
Advisor: Dr. Cong-Gui Zhao
Development of new methodology to synthesize bioactive molecules using organocatalyst
Completed highly enantioselective synthesis of β-(3-hydroxypyrazol-1-yl) ketones using an
organocatalyzed Michael addition reaction
Completed enantioselective synthesis of aldol adducts using modularly designed
organocatalytic assemblies of organocatalyst
Completed
organocatalyzed
enantioselective
synthesis
of
6-amino-5cyanodihydropyrano[2,3-c]pyrazoles
Senior Research Fellow, National Chemical Laboratory, Pune, India
Advisor: Dr. N. P. Argade
Completed the first synthesis of germination inhibitor (+)-erigeronic acid and its analogous
Completed the synthesis of plant growth regulator (–)-saccharinic acid lactone and leaf
closing compound potassium (2R,3R)-2,3,4-trihydroxy-2-methylbutanoate by using enzyme
Amano PS
Completed the synthesis of pandanus alkaloid (±)-Norpandamarilactonines A-B, (±)Pandamarilactonines A-D and Pandanamine
Junior Research Fellow, National Chemical Laboratory, Pune, India
Advisor: Dr. N. P. Argade
Completed first synthesis of leaf-closing compound (±)-erythro potassium 2,3,4-trihydroxy2-methyl-butanoate
Completed the synthesis of marine anti-fouling agents maculalactones A-C and cytotoxic
nostoclide I
Completed the first synthesis of cytotoxic ellipsoidone A and B
OTHER EXPERIENCE AND TECHNICAL SKILLS
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Worked for eight months (2002), as project assistant (isolation of natural product) at
Regional Research Laboratory (CSIR), Jorhat, Assam, India
Worked as a chemist for three months (2002), in Dr. Reddy’s Laboratory, one of the
leading pharmaceutical industry in India
Experience in design and synthesis of a variety of biologically active natural products and
synthetic molecules and expertise in multistep synthesis
Experience with purification and separation techniques pertinent to synthetic organic
chemistry
Expertise in analysis of compounds by NMR, MS, FTIR, and UV
Expertise in operating NMR, UV-Vis spectroscopy, analytical/semi-preparative HPLC,
HPLC with EC detector
Experience in working Molecular Modeling Softwares like Sybyl, MOE on linux red hat
Profound efficiency in handling of hygroscopic, air sensitive reagents and reactions
Identification of research problems and resolving them independently
Capable of performing collaborative as well as independent research
SANJIB GOGOI, Ph.D.
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 Familiar with Microsoft Office, Chem. Draw, ISIS Draw, Versamax, Rotomax etc
 Excellent communication and presentation skills in both oral and written form
 An easy going and friendly interpersonal relationship
 Experience in cell culture techniques
 Adept at maintaining cell lines including N-27, SH-SY5Y
 Experience in performing in vivo pharmacological assays including animal model of
Parkinson’s disease using 6-hydroxy dopamine treated unilaterally lesioned rats, locomotor
activity test using animal activity monitor (Versamax), forced swim test and tail suspension
test to evaluate the antidepressant activity of a compound
 Experience in performing biochemical colorimetric assays to evaluate the antioxidant
property of a compound
 Experience in performing cytotoxicity assay (MTT assay) to evaluate the toxicity as well as
the neuroprotective efficacy of a compound upon treatment with known neurotoxic agent
on N-27 and SH-SY5Y cell lines
AWARDS AND HONORS
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Senior Research Fellowship (SRF), Council of Scientific and Industrial Research (CSIR),
Government of India, India (2004-2007)
Junior Research Fellowship (JRF), Council of Scientific and Industrial Research (CSIR),
Government of India, India (2003-2004)
Ranked first in M.Sc.(Organic Chemistry) of 1999-2001, Dibrugarh University, Assam,
India
RESEARCH INTERESTS
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Medicinal Chemistry, mainly to discover novel drugs for the CNS to explore their potential
therapeutic application in several neuro-disorders like Parkinsonís disease (PD), depression
and drug addiction
Total synthesis of bioactive natural products and natural product hybrids
Development of novel organocatalysts for enantioselective reactions
Combinatorial chemistry and drug design
Chemoenzymatic preparation of important chiral compounds & intermediates and also
the development of enzymes as reagents for effecting organic transformations
PROFESSIONAL SOCIETIES
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Member, American Association of Pharmaceutical Scientist (AAPS)
POSTER/ORAL PRESENTATION
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Poster presented in 40th Neuroscience, SfN's 40th annual meeting, San Diego, CA, USA
Nov. 13-17, 2010
Poster presented in 237th ACS National Meeting, Salt Lake City, UT, USA, March 22-26,
2009
Poster presented in the Science Day Celebration at National Chemical Laboratory, Pune,
India during February, 2007
SANJIB GOGOI, Ph.D.
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 Oral presentation of Ph. D. work in Junior National Organic Symposium Trust (JNOST)
held at International girls college, Jaipur, India during October, 2006
 Poster presented in the Ramanbhi foundation 2nd international symposium on “Current
Trends in Pharmaceutical Sciences” held at Zydus Research Centre, Ahmedabad, India
during January, 2005
PEER REVIEWED PUBLICATIONS
1. Synthesis of potassium 2,3,4-trihydroxy-2-methylbutanoate: a leaf-closing substance of
Leucaena leucocephalam
Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2004, 60, 9093.
2. Synthesis of naturally occurring bioactive butyrolactones: maculalactones A–C and
nostoclide I
Anirban Kar, Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2005, 61, 5297.
3. A facile chemoenzymatic approach to natural cytotoxic ellipsoidone A and natural
ellipsoidone B
Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2006, 62, 2715.
4. A facile two-step chemoenzymatic access to natural germination inhibitor (+)-erigeronic
acid A
Sanjib Gogoi and Narshinha P. Argade* Tetrahedron 2006, 62, 2999.
5. An efficient Amano PS-catalyzed chemo-, regio- and enantioselective hydrolysis of (±)-2,3di-O-acetyl-2-C-methyl-D-erythrono-1,4-lactone: a facile preparation of bioactive natural
products
(–)-saccharinic
acid
lactone
and
potassium
(2R,3R)-2,3,4-trihydroxy-2-
methylbutanoate
Sanjib Gogoi and Narshinha P. Argade* Tetrahedron: Asymmetry 2006, 17, 927.
6. Synthesis of norpandamarilactonines, pandamarilactonines and pandanamine
Sanjib Gogoi and Narshinha P. Argade* Synthesis 2008, 1455.
7. Enantioselective
Synthesis
of
-(3-Hydroxypyrazol-1-yl)
Ketones
Using
an
Organocatalyzed Michael Addition Reaction
Sanjib Gogoi, Cong-Gui, Zhao,* Derong, Ding Organic Letters 2009, 11(11), 2249.
8. Organocatalyzed
enantioselective
synthesis
of
6-amino-5-cyanodihydropyrano[2,3-
c]pyrazoles
Sanjib Gogoi, Cong-Gui Zhao* Tetrahedron Letters 2009, 50(19), 2252.
9. Dopamine D2/D3 agonist with potent iron chelation and antioxidant properties: Potential
implication in symptomatic and neuroprotective treatment of Parkinson’s disease
SANJIB GOGOI, Ph.D.
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Sanjib Gogoi, Tamara Antonio, Maarten Reith and Aloke Dutta* Chem. Med. Chem 2011,
6, 991.
10. Development of an efficient asymmetric synthetic route to a novel triple uptake inhibitor
antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran4-ol (D-142).
Bhaskar Gopishetty, Sanjib Gogoi, Aloke Dutta* Tetrahedron: asymmetry 2011, 22, 1081.
11. The novel trisubstituted pyran derivative D-142 with triple monoamine reuptake inhibitory
activity: potent antidepressant-like activity from animal models of depression studies.
Aloke Dutta,* Bhaskar Gopishetty, Sanjib Gogoi, Solav Ali, Juan Zhen, Maarten Reith Eur.
J. Pharmacol. 2011, 671, 39.
12. Facile ultrasound-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione fused
steroidal derivatives by a three-component reaction
Mandakini Dutta, Junali Gogoi, Kommoori Shekarrao, Jonalee Goswami, Sanjib Gogoi*
and Romesh Chandra Boruah* Synthesis 2012, 44, 2614-2622.
13. A microwave promoted solvent-free approach to steroidal quinolines and their in-vitro
evaluation for antimicrobial activities
Shyamalee Gogoi, Kommuri Shekarrao, Aparajita Duarah, Tarun C Bora, Sanjib Gogoi,
Romesh C Boruah* Steroids 2012, 77, 1438-45.
14. (3S,6S)-6-Benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine Analogues: Identification of
Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants.
Santra, Soumava; Gogoi, Sanjib; Gopishetty, Bhaskar; Antonio, Tamara; Zhen, Juan;
Reith, Maarten E. A.; Aloke K. Dutta, Chem. Med. Chem. 2012, 7, 2093-2100.
15. Asymmetric Aldol reaction catalyzed by modularly designed organocatalysts.
Sinha debarshi, Mandal Tanmay, Gogoi Sanjib, Goldman Joshua, Zhao, Cong-Gui Chin.
J. Chem. 2012, 30, 2624-2630.
16. Novel bivalent ligands for D2/D3 dopamine receptors: significant cooperative gain in D2
affinity and potency.
Sanjib Gogoi, Swati Biswas, Modi Gyan, Antonio Tamara, Maarten E Reith, Aloke K
Dutta ACS Med. Chem. Lett. 2012, 3, 991-996
17. A rapid and convenient synthesis of 3, 5 disubstituted 2-chloropyridines and tetrazolo[1,5a]pyridines under microwave irradiation
Shyamalee Gogoi, Sanjib Gogoi, Romesh C Boruah Synthesis 2013, 45, 219-24.
SANJIB GOGOI, Ph.D.
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18. Microwave-promoted and Lewis acid catalysed synthesis of steroidal A- and D-ring fused
4,6-diarylpyridines.
Mandakini Dutta, Pallabi Saikia, Sanjib Gogoi*, Romesh C. Boruah*. Steroids 2013, 78,
387-395.
19. Palladium-catalyzed multi-component synthesis of steroidal A- and D-ring fused 5,6disubstituted pyridines under microwave irradiation.
Kommuri Shekarrao, Dipankar Nath, Partha Pratim Kaishap, Sanjib Gogoi,* Romesh C
Boruah*. Steroids 2013, http://dx.doi.org/10.1016/j.steroids.2013.08.002.