Download Mitochondrial NRG - Designs for Health

Mitochondrial NRG™
By David Brady, ND, DC, CCN, DACBN & Suzanne Copp, MS
THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING
WHETHER OR NOT TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE
BY CONSUMERS. THE DIETARY SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS
AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION.
Mitochondrial NRG™ is a formulary blend of nutrients, nutraceuticals, botanicals, and Krebs cycle
intermediates designed to support efficient mitochondrial metabolism and energy (ATP) production
for increased vitality.
Mitochondrial NRG™ may be indicated for those individuals suffering with debilitating fatigue,
including those diagnosed with chronic fatigue syndrome (CFS) and fibromyalgia (FMS), those
wanting to increase energy output for improved athletic performance, and anyone wishing to
improve overall cellular and tissue vitality and health.
It has been well established in the scientific medical literature that mitochondrial dysfunction, with its associated ATP deficiency, is related to a host of diseases, including degenerative neurological disorders (i.e., Alzheimer’s, Parkinson’s, multiple
sclerosis, amyotrophic lateral sclerosis), cardiovascular disease (i.e.,
heart attack, stroke, peripheral vascular disease), obesity, and diabetes
(reduced mitochondrial biogenesis has been demonstrated in metabolic syndrome). Mitochondria deteriorate with age due to ongoing
exposure to free radicals, which accelerate the destruction of cellular
components. As the mitochondrial function declines the cells become
starved for energy and damaged, causing them to function less efficiently. Many investigators suspect that caloric restriction slows aging
primarily by lowering free radical production in mitochondria.
Conversely, the benefits of increased mitochondrial biogenesis and
ATP availability are many, including the reduction of oxidative stress
and age–related deterioration as well as improvements in metabolic
function, energy level, exercise performance, body composition, cognitive function, and lifespan (shown in animal models).
Mitochondrial NRG™ may be used for:
•
•
•
•
•
•
•
•
•
Fatigue / Chronic Fatigue Syndrome (CFS)
Fibromyalgia (FMS)
Exercise intolerance
Improved athletic performance
Post-exercise muscle soreness
Efficient fat burning
Healthy weight loss
Poor cognitive (brain) function
Those wishing to improve overall cellular and
tissue vitality and health
• Mitochondrial genetic mutations, either inborn
or acquired during aging or due to excessive
exercise (such as mitochondrial myopathy)
Krebs Cycle Pathway
To contact Designs for Health, please call us at (800) 847-8302, or visit us on the web at www.designsforhealth.com.
ZTEC MHN 12/12
Mitochondrial NRG™ contains nutrients known to aid in
factors in mitochondrial energy production, including:
Supplement Facts
Serving Size 4 capsules
Servings Per Container 30
% Daily Value Amount Per Serving
% Daily Value
• CoQ10 – rate-limiting nutritional factor in the electron transport Amount Per Serving
100 mg
Thiamin (Vitamin B-1)(as Thiamin HCL) 50 mg 3330% D-Ribose
*
chain (using the same patented water soluble VESIsorb™ Riboflavin (Vitamin B-2)
100 mg
10 mg 590% Malic Acid
*
100 mg
(as Riboflavin-5-Phosphate)
Succinic Acid
*
technology as in our Q-Avail Nano softgels and powder, to Vitamin
5 mg
25% Natural Coenzyme Q10 (Ubiquinone) 100 mg
B-3 (as Niacinamide)
*
100 mg
Vitamin B-6 (as Pyridoxal-5-Phosphate) 5 mg 250% Alpha Lipoic Acid
*
insure optimal bioavailability)
100 mg
Vitamin B-12 (as Methylcobalamin) 2000 mcg 33330% Trans Resveratrol
*
100
mg
25%
Magnesium
from
200
mg
Polygonum
cuspidatum
(root)
*
• Alpha Lipoic Acid - cofactor in multi-enzyme complexes that (as Creatine MagnaPower® Magnesium Creatine Chelate) Curcumin C3 Complex®
100 mg
*
500 mcg
25%
(Curcuma longa)(rhizomes)
catalyzes oxidative decarboxylation of alpha-keto acids such as Manganese
(TRAACS® Manganese Glycinate Chelate)
(containing three curcuminoids: curcumin,
bisdemethoxy curcumin, demethoxy curcumin)
the pyruvate dehydrogenase complex
550 mg
*
Creatine
[standardized to contain 95% curcuminoids]
• Pantethine - necessary to shuttle fats from the blood stream across (as Creatine MagnaPower® Magnesium Creatine Chelate) Pantethine
50 mg
*
200 mg
*
L-Carnitine (as Fumarate)
150 mg
* *Daily Value not established.
Fumaric Acid
the cellular membrane for cell entry
(from L-Carnitine Fumarate)
• L-Carnitine - necessary to shuttle those same fats across the mito chondrial membranes for burning
Other Ingredients: Microcrystalline cellulose, silicon dioxide, vegetable
• B Vitamins, Magnesium and Manganese - required as Krebs cycle
stearate, patented VESIsorb® formula (medium chain triglycerides, polysorbate
80, polyglycerol esters of fatty acids, citrus oil extract [Citrus sinensis][peel],
enzyme cofactors
vitamin E), maltodextrin, calcium silicate, ubiquinone.
• Ribose - a nucleotide repleter and direct cellular energy source
• Malic, Fumaric, and Succinic Acids - for refilling of key Krebs cycle
intermediates
• Creatine - to support additional energy production (using Albion’s
patented Creatine MagnaPower®, which supplies creatine and
magnesium together, both needed for healthy mitochondria)
• Resveratrol and Curcumin - botanicals shown to induce the production of
additional mitochondria (mitochondrial biogenesis) through SIRT1 gene
signaling and PGC-1-alpha induction. This resveratrol is in the well-absorbed
trans form, the form believed to be responsible for activating the SIRT1 gene,
which when turned on slows the aging process.
Suggested Dosage: Take four capsules daily, two capsules twice a day with meals, or as directed by your health care practitioner.
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
Advanced Nutrition and Human Metabolism (with InfoTrac) by Sareen S. Gropper 4th Edition (April 16, 2004) ISBN: 0534559867: Wadsworth Press
Textbook of Biochemistry with Clinical Correlations by Devlin 6th Edition: ISBN: 0471678082
Food and Nutrients in Disease Management by Ingrid Kohlstadt. CRC Press ISNB: 978-1-4200-6762-0
Resveratrol improves health and survival of mice on a high calorie diet. Baur JA et al. Nature. 2006 Nov 16;444(7117):337-42. Epub 2006 Nov 1.
Therapeutic potential of resveratrol: the in vivo evidence. Baur JA, Sinclair DA. Nat Rev Drug Discov. 2006 Jun;5(6):493-506. Epub 2006 May 26. Review.
Diminution of Singlet Oxygen-induced DNA Damage by Curcumin and Related Antioxidants. Subramanian M, et al. Mutat Res. Dec1994;311(2):249-55.
Biological activities of Curcuma. Araujo CC, Leon LL.longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.
Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Muller DM, Seim H. Metabolism 2002 Nov;51(11):1389-91.
L-Carnitine: therapeutic applications of a conditionally-essential amino acid. Kelly GS. Altern Med Rev. 1998 Oct;3(5):345-60.
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Shults CW, Oakes D, Kieburtz K, et al. Arch Neurol. 2002 Oct;59(10):154150.
Fatigue in chronically ill patients. Harris JD. Curr Opin Support PalliatCare. 2008 Sept;2(3):180-6.
Textbook of Natural Medicine (2nd Ed.), Pizzorno JE, Murray MT. Churchill Livingstone, New York, 1999.
Complimentary & Alternative Medicines: Professional’s Handbook. Fetrow CW, Avila JR. Springhouse, Springhouse, PA, 1999.
Botanical Influences on Illness: A sourcebook of clinical research. Werbach MR, Murray, MT. Third Line Press, Tarzana, California, 1994.
Incorporating Herbal Medicine Into Clinical Practice. Bascom A. F.A. Davis Co., Philadelphia, 2002.
Encyclopedia of Herbal Medicine. Cheallier A. Dorling Kindersley, London, 2000.
Pharmacognosy and Pharmacobiotechnology. Robbers JE, Speedie MK, Tyler VE. Williams & Wilkins, Baltimore, 1996.
PDR for Nutritional Supplements, 1st Ed. Medical Economics/Thompson Healthcare, 2001.
PDR for Herbal Medicines, 1st Ed. Medical Economics/Thompson Healthcare, 1998.
The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies. Tarnopolsky MA. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1561-7.
Epub 2008 Jul 4.
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA. Muscle
Nerve. 2007 Feb;35(2):235-42.
R-alpha-Lipoic acid and acetyl-L: -carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Shen W, Liu K, Tian C, Yang L, Li X, Ren J,
Packer L, Cotman CW, Liu J. Diabetologia. 2008 Jan;51(1):165-74. Epub 2007 Nov 17.
Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. Prahl S, Kueper T, Biernoth T, Wöhrmann Y, Münster A, Fürstenau M, Schmidt M,
Schulze C, Wittern KP, Wenck H, Muhr GM,Blatt T. Biofactors. 2008;32(1-4):245-55.
Antifatigue effect of coenzyme Q10 in mice. Fu X, Ji R, Dam J. J Med Food. 2010 Feb;13(1):211-5.
To contact Designs for Health, please call us at (800) 847-8302, or visit us on the web at www.designsforhealth.com.