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MESOTHERAPY in DERMATOLOGY www.geosmatic.com Indications z Hair: Telogen effluvium Androgenetic Alopecia z Face : Facial rejuvenation (wrinkles + Firming) Facial pigmentation e.g. melasma. Indications z Body Localised fat areas . Cellulite. Stretch marks. How To Start 1. 2. 3. 4. 5. Materials & protocols / indication. Injection sites. Injection Depths. Needle size. Machine. Materials Classified into : z Principals(Major) z Complementary(Minor) TIP: Mixture should contain 2-3 principals to achieve satisfactory results(>90%). Hair z Principals Telogen Effluvium Biotin Hair (Vitamin H/B7) Growth Pantothenic Stimulants acid (Vitamin B5) Complementary Pyridoxine (Vitamin B6) Zinc + Azelaic acid MV + MTE Hair z AGA Principals Hair Growth Minoxidil Stimulants Finasteride 5-ARI Dutasteride Complementary Zinc + Azelaic acid MesoHair Protocols Telogen Effluvium Androgenetic Alopecia Biotin (P) Dexenol(P) MV + MTE (C) Minoxidil(P) / Dutasteride(P) + Biotin(P) Dexenol(P) Zinc + Azelaic (C) MesoHair Injection sites & depths 1-2mm Face MesoLift / MesoGlow z Rejuvenation (Major) Proven to Stimulate collagen synthesis Hyaluronic acid z Amino acids z Vitamin C z Organic Silicium z Fibronectin + Vegetal proteins (Collagen & Elastin) z Vitamin A z Face MesoLift / MesoGlow z Rejuvenation Glycolic acid z Taurine z XADN z MV & MTE z (Complementary) Major Firming z DMAE : 1. Potent firming acts quickly and lasts long. 2. Acts in the neuromuscular union, as a precursor of acetylcholine, the neurotransmitter responsible for muscular contraction, increasing the overall tone of the skin. z DMAE + Organic Silicium MesoGlow Protocols Glow HA (P) Lift (Firming) HA (P) Silorg (P) Silorgamine = Silorg + DMAE (P) Purascorbol / Vitamin C (P) Puretinol / Vitamin A (P) Xadenal (C) Taurinox (C) MesoGlow/Lift Injection sites & depths 1-2mm Face Pigmentation Principals z MesoLighten ▼ Melanogenesis Glutathione Kojic Vitamin C Azelaic acid Complementary Glycolic acid Tretinoin MesoLighten Protocols Kojic acid (P) Azelaic acid (P) Vitamin C (P) Tretinoin (C) Glutathione (P) Kojic acid (P) Vitamin C (P) Glycolic acid (C) MesoLighten Injection sites & depths 1-2mm Body z Localized Fat z Cellulite z Stretch marks Localized Fat z LipoDissolve = Injection Lipolysis Localized Fat IAAL Injection Lipolysis Mesotherapy Deep 12mm PPC + DOC (PCDC) Hyaluronidase-CollagenaseArtichoke Intermediate 6mm (L-Carnitine-AminophyllineYohimbine- Artichoke) 2 - 4 mm L-Carnitine Aminophylline Pentoxifylline Effective complement Phosphatidyl Choline (PPC) z An antioxidant derived from soy lecithin. z PPC penetrates the adipocyte , breaks down fat . Dissolved fat is carried through bloodstream and excreted by kidneys and bowel.(P) z LipoDissolve + proper diet + Exercise. Localized Fat/ Injection Lipolysis Lipolytic Enhancers: z Deoxycholate: Bile salt(P). z L-Carnitine: Enhances both lipolysis and fatty acid oxidation(P) z Artichoke: Direct lipolytic (P) z Aminophylline , Caffeine & Xanthine(P) z Hyaluronidase & Collagenase: PPC enhancer Enzymes (C) PPC + DOC z Detergent Effects of Sodium Deoxycholate Are a Major Feature of an Injectable Phosphatidylcholine Formulation Used for Localized Fat Dissolution. Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Dermatol Surg 2004;30:1001-8. Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA. Conclusions: The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes. Our findings suggest that sodium deoxycholate is the major active component responsible for cell lysis.Thus,eliminating unwanted adipose tissue. Localized Fat/ Injection Lipolysis Circulatory Enhancers: z Yohimbine:Alpha2-adrenergic Blocker. z Aminophylline &Pentoxiphylline: PDEI Drainage Enhancers: z Artichoke:Diuretic and stimulates lymphatic drainage Localized Fat/ Injection Lipolysis Protocols Phosphatidylcholine(P) Deoxycholic Acid(P) Vitamin complex Alpha Lipoic Acid Amino Acids Phosphatidylcholine(P) Deoxycholic Acid (P) Taurine Organic silicium Phosphatidylcholine(P) Deoxycholic Acid (P) L-Carnintine Aminophylline Pantothenic Acid LipoDissolve Injection sites & depths12mm Cellulite z Aesthetically cellulite is a problem consisting of the visual presentation of weakened and damaged fatty tissue and connective fibrous tissue in the form of bumps and dimples, commonly known as “orange skin”. Cellulite Treatment must act in two different ways: z on the fat (Lipolytic effect) z on circulation (Venotonic effect + Drainage) Cellulite z Lipolytic: L- Carnitine + Caffeine . z Venostatic: Rutin – Aminophylline –Pentoxiphylline. z Drainage: Artichoke. Cellulite Protocols z z z z z z L- Carnitine Aminophylline Pentoxiphylline Yohimbine DMAE Procaine All are Principals z z z z z z L- Carnitine Aminophylline Pentoxiphylline DMAE Vitamin C Procaine Stretch Marks The connective tissue, including collagen and elastin, becomes increasingly damaged until eventually causing the formation of stretch marks. Stretch Marks Collagen Elastin Stimulating/ Restoring agents Organic Silicium / Silorg z Centella Asiatica z Vegetal proteins + Fibronectin z Firming agents z DMAE + Vitamin C z DMAE + Idebenone. MesoStretch Marks Protocols Silorgamine = Silorg + DMAE z z z z Idebe = Idebenone + DMAE z z z z All are Principals Centella Asiatica Fibronectin Vegetal Proteins Vitamin C DMAE Silorg Needle size 30/32 G x 4 mm z 30/32 G x 6 mm z 30/32 G x 12.7 mm z MesoGuns Meso Doctor Syringe Infusion Pump Injection Techniques z PAPULE: 1 to 2mm, with bevel upwards z NAPPAGE: 2 to 4mm, angle of 30° to 60° z POINT BY POINT: deep injections, 4 to 12mm Contraindications Pregnancy, blood thinners, IDDM, cancer patients, AIDS patients, coronary artery heart disease or heart dysfunction, People with arrhythmias, history of blood clots or strokes, autoimmune diseases or organ transplant recipients and skin conditions including: herpes & psoriasis. MESOPORATION z Mesotherapy ------ Non invasvive z No needles are required. MESOPORATION A new complex process utilizes the skin's water based "channels" to allow ionic drug solutions to penetrate into the skin, via controlled "electroporation - like" electrical pulses. MESOPORATION MESOPORATION MESOPORATION ADVANCED MOLE TRANSFER AN M V AD EN TS For face and body treatment with electroporaction and dermoabrasion CE ST DM ED I C AL I N RU MesoLighten Injection sites & depths 1-2mm MesoLighten Injection sites & depths 1-2mm MesoLighten LipoDissolve LipoDissolve Injection sites & depths12mm Cellulite Cellulite MesoCellulite Injection sites & depths 2mm MesoCellulite MesoStretch Marks Injection sites www.geosmatic.com