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Product Monograph for Herbal Magic Chewable Multi NPN 80056032 GENERAL INFORMATION Herbal Magic’s Chewable Multi is a great tasting chewable multivitamin/mineral tablet which contains a blend of vitamins and minerals formulated to help meet the nutritional needs of those aged 12 and over. Vitamins by definition are dietary substances required for good health and normal development. Their functions can be quite complex wherein any particular vitamin may have various metabolic and chemical roles. Minerals, like vitamins, act as co-enzymes enabling the body to perform its functions including energy production, growth and healing. This formulation is useful for those who have difficulty swallowing tablets or capsules. Chewable Multi is a fundamental comprehensive multivitamin/mineral designed to fill potential nutritional gaps and support successful weight management. This daily multivitamin helps to: Ensure the body is functioning optimally Promote efficient metabolism by breaking down food and ensuring optimal thyroid function Ensure optimal intake of nutrients to prevent nutritional deficiencies Support healthy skin RECOMMENDED USES Primary Uses: helps maintain good health; helps in the metabolism of carbohydrates, fats and proteins; helps normal growth and development. Secondary Use: Supports healthy skin. MECHANISM OF ACTION Research Suggests Biotin Biotin is a water-soluble vitamin that plays an essential role in maintaining metabolic homeostasis. Biotin acts as a cofactor in gluconeogenesis, fatty acid synthesis and amino acid catabolism. 1,2,3 Copper Copper is an essential trace metal that plays an integral part in numerous critical enzyme processes affecting vital biological systems. Copper helps to produce and repair connective tissue, and aids in formation of red blood cells. 4,5 Iron Iron is a vital trace mineral that participates in a wide variety of metabolic processes, including oxygen transport, DNA synthesis, and electron transport. Iron concentrations in the body are tightly regulated. 6,7 Low iron stores can lead to fatigue, weakness, decreased energy, loss of appetite and impaired cognitive functioning.8 Magnesium Magnesium is critical to normal human homeostasis playing many roles in energy metabolism: as an enzyme cofactor, in electrolyte balance, and in the maintenance of the properties of various cell membranes. As one of the four most abundant cations in the body, magnesium is present in more than 300 enzymatic systems. 9,10 Magnesium helps the body to metabolize carbohydrates, fats and proteins. Magnesium also plays an important role in maintaining muscle function and in the absorption of calcium. 10,11 Niacinamide Niacinamide is an essential organic compound for metabolism, essential for energy production from carbohydrates, fatty acids, and amino acids.12 Niacinamide is necessary for a variety of diverse biological processes including energy production and acts as an antioxidant.13 Pantothenic acid Pantothenic acid is involved in the metabolism of carbohydrates, proteins and lipids and is a component of coenzyme A, a molecule necessary for many vital chemical reactions to occur in cells.14,15 Riboflavin Riboflavin is a water-soluble vitamin, important for human metabolism, protecting against cancer and cardiovascular disease. The body requires more riboflavin in cases of increased metabolic demand such as during weight loss or in periods of high stress. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and sufficient replenishing of this essential vitamin. 16,17 Thiamine Thiamine is a water-soluble vitamin, essential in metabolic energy production and the metabolism of fats, carbohydrates and proteins. As humans are unable to synthesize thiamine, this vitamin must be obtained exogenously. The body requires more thiamine in cases of increased metabolic demand such as during weight loss. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and adequate supply of this essential vitamin. 18,19 Vitamin A Vitamin A has several functions in the body, including supporting healthy growth, repair and maintenance of epithelial cells, bone and tooth development, and a healthy immune system. Vitamin A is also critical in the maintenance of healthy vision. Due to deficiency in the diet, or lack of variety in the diet, many may be missing important nutrients for maintaining eye health. Vitamin A supports the healthy surface linings of the eyes, without which the eyes could become susceptible to infection. Additionally, a deficiency in vitamin A could lead to night blindness. 20 Vitamin B6 Vitamin B6 acts as cofactor in more than 140 different enzyme reactions and has critical functions in cellular metabolism and stress responses. It is a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular health. 21,22,23 Vitamin B12 Vitamin B12 aids in the formation and regeneration of red blood cells, thereby preventing anemia. Vitamin B12 promotes growth and is essential for the maintenance of a healthy nervous system. Vitamin B12 supports normal DNA synthesis, promotes growth24, and also assists in the proper utilization of fats, carbohydrates and proteins.18,25 F OR PROFESSIONAL U SE O NLY F OR P ROFESSIONALS TO RECEIVE A PRINTED COPY OF THIS MONOGRAPH , CONTACT HERBAL M AGIC CLINICAL SUPPORT AT [email protected] OR 1-866-787-0050. 11/09/15 Rev 0 1 of 3 Vitamin C Humans are unable to synthesize vitamin C and therefore must obtain this vitamin exogenously. Vitamin C works as an antioxidant in the body and is one of the most important vitamins responsible for collagen, carnitine and neurotransmitter biosynthesis. 26,27,28 As an antioxidant, vitamin C can help to limit the damaging effects of free radicals29 which can compromise the vital health of cells and can lead to the onset of various chronic conditions.30,31 Vitamin D Vitamin D is a fat-soluble vitamin that plays a pivotal role in maintaining health.32 Vitamin D assists the absorption of calcium and phosphorus in the intestines and is important during periods of growth as it plays a critical role in bone mineralization.33,34 While the majority of individuals may be deficient in Vitamin D, several groups are at high risk for vitamin D deficiency, including overweight individuals.35,36 Supplementation in these groups is, therefore, especially important. A healthy diet with adequate calcium and vitamin D, and regular physical activity, helps to achieve strong bones.37 Vitamin E Vitamin E is a fat-soluble vitamin, best known for its major function as an antioxidant that prevents the formation of free radicals and repairs free radical cell damage.38 Zinc Zinc is an essential co-factor in a variety of cellular processes affecting reproduction, bone formation, growth, and wound healing. Zinc has been purported to play an important role in normal thyroid homeostasis. 39,40,41 RECOMMENDED DOSAGE For Ages 12+: 1 chewable tab 2x/day with meals, a few hours before or after other medications. CAUTIONS AND WARNINGS No Statement. DISEASE/CONDITION INTERACTIONS No Statement. DRUG INTERATIONS No Statement. To prevent any interactions, all Herbal Magic centres offer our unique Medication Cross-Reference System, designed to provide evidence-based safe dosing options for Herbal Magic products such as Chewable Multi with other medications that the client is taking. FORMULATION Medicinal Ingredients per chewable: Biotin ............................................................................. 5 mcg Copper (Cupric citrate) .................................................. 500 mcg Iron (Ferrous fumarate) ..................................................... 5 mg Magnesium (Magnesium oxide) ......................................... 10 mg Niacinamide ...................................................................... 5 mg Pantothenic acid (Calcium-D-pantothenate) ..................... 2.5 mcg Riboflavin ....................................................................... 2.5 mg Thiamine (Thiamine mononitrate) .................................... 2.5 mg Vitamin A (All-trans retinyl palmitate) ………. 700 mcg RAE/2316 IU Vitamin B6 (Pyridoxine hydrochloride) ................................. 1 mg Vitamin B12 (Cyanocobalamin) .......................................... 2 mcg Vitamin C (Ascorbic acid) .................................................. 50 mg Vitamin D (Cholecalciferol) ................................ 2.5 mcg / 100 IU Vitamin E (dl-α-Tocopheryl acetate) …................. 1.4 mg AT/ 3 IU Zinc (Zinc sulfate) ........................................................... 0.5 mg Non-medicinal Ingredients: Sucrose, stearic acid, natural fruit flavor, citric acid, turmeric, magnesium stearate, silica, beetroot red. Features: Gluten Free Dairy Free Only natural colours and flavours are included. For further information, please contact the Herbal Magic Scientific Advisory Team at 1-866-787-0050. REFERENCES 1 Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009;35(1):36-46. 2 Health Canada. Natural Health Products Directorate. Product Monographs. Biotin. 2007. Available at: http://webprod.hcsc.gc.ca/nhpid-bdipsn/monoReq.do?id=41&lang=eng. Accessed May 21, 2015. 3 Gravel RA, Narang MA. Molecular genetics of biotin metabolism: old vitamin, new science. J Nutr Biochem. 2005;16(7):428-31. 4 Health Canada. Natural Health Products Directorate. Product Monographs. Copper. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015. 5 Gaetke L.M, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients, Toxicology. 2003;189(1-2):147-63. 6 Lieu PT, Heiskala M, Peterson PA, et al. The roles of iron in health and disease. Mol Aspects Med. 2001;22(1-2):1-87. 7 Nadadur SS, Srirama K, Mudipalli A. Iron transport & homeostasis mechanisms: their role in health & disease. Indian J Med Res. 2008;128(4):533-44. 8 National Institutes of Health. Dietary Supplement Fact Sheet: Iron. http://ods.od.nih.gov/factsheets/IronHealthProfessional. 9 Health Canada. Natural Health Products Directorate. Product Monographs. Magnesium. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015. 10 Fox C, Ramsoomair D, Carter C. Magnesium: Its Proven and Potential Clinical Significance. South Med J. 2001;94(12):1195201. 11 Health Canada. Natural Health Products Directorate. Product Monographs. Magnesium. 2007. Available at: http://webprod.hc-sc.gc.ca/nhpidbdipsn/monoReq.do?id=135&lang=eng. Accessed May 21, 2015. 12 Health Canada. Natural Health Products Directorate. Product Monographs. Niacinamide 2009. Available at http://webprod.hc-sc.gc.ca/nhpidbdipsn/monoReq.do?id=142&lang=eng. Accessed May 21, 2015. 13 Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ F OR PROFESSIONAL U SE O NLY F OR P ROFESSIONALS TO RECEIVE A PRINTED COPY OF THIS MONOGRAPH , CONTACT HERBAL M AGIC CLINICAL SUPPORT AT [email protected] OR 1-866-787-0050. 11/09/15 Rev 0 2 of 3 precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. 14 Picciano MF, Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. J. Nutr. 2003;133(6): 1997S-2002S. 31 Shils M.E., Olson J.A., Shike M., Ross A.C., editors. (2006). Modern Nutrition in Health and Disease, 10th edition. Lippincott Williams and Wilkins 32 Planton J, Meyer JO, Edlund BJ. Vitamin d. J Gerontol Nurs. 2011;37(1):9-13. 15 Health Canada. Natural Health Products Directorate. Product Monographs. Pantothenic Acid 2007. Available at: www.hcsc.gc.ca Accessed May 21, 2015. 33 Health Canada. Natural Health Products Directorate. Product Monographs.Vitamin D. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015. 16 Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352-60. 34 Rabovsky BA, Komarov AM, Ivie JS, Minimization of free radical damage by metalcatalysis of multivitamin/multimineral supplements. Nutrition Journal. 2010;9:61. 17 Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements? Int J Sport Nutr Exerc Metab. 2006; 16(5):453-84. 18 Gagnolf M, Czerniecki J, Radermecker M. Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE. 2010;5:10, e13616. 19 Singleton CK, Martin PR. Molecular mechanisms of thiamine utilization. Curr Mol Med. 2001;1(2):197-207. 20 National Institutes of Health: Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin A and Carotenoids. Available at: http://ods.od.nih.gov/factsheets/VitaminA 21 di Salvo ML, Contestabile R, Safo MK. Vitamin B(6) salvage enzymes: Mechanism, structure and regulation. Biochim Biophys Acta. 2010;[Epub ahead of print]. 22 Mooney S, Leuendorf JE, Hendrickson C, et al. Vitamin B6: a long known compound of surprising complexity. Molecules. 2009;14(1):329-51. 23 Health Canada. Natural Health Products Directorate. Product Monographs. Pyroxidine-5-phosphate. 2007. Available at: www.hc-sc.gc.ca. Accessed May 21, 2015. 24 Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998. Available from: http://www.ncbi.nlm.nih.gov/books/NBK114310 35 Caan B, Neuhouser M, Aragak A, et al. Calcium Plus Vitamin D Supplementation and the Risk of Postmenopausal Weight Gain. Arch Intern Med. 2007;167(9):893-902. 36 De-Regil Luz, Palacios Cristina, Ansary Ali, et al. Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews, 2012;Issue 2. 37 L'Abbe MR, Whiting SJ, Hanley DA. The Canadian health claim for calcium, vitamin D and osteoporosis. J Am Coll Nutr. 2004; 23:303-8. 38 Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem. 2001;57(1):43-56.)( Mustacich DJ, Bruno RS, Traber MG. Vitamin E. Vitam Horm. 2007;76:1-21. 39 Ertek S, Cicero AF, Caglar O, Erdogan G. Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Hormones (Athens). 2010;9(3):263-8. 40 Health Canada. Natural Health Products Directorate. Product Monographs. Zinc. 2007. Available at: www.hc-sc.gc.ca. Accessed May 21, 2015. 41 Barceloux DG. Zinc. J Toxicol Clin Toxicol. 1999;37(2):279-92. 25 Health Canada. Natural Health Products Directorate. Product Monographs. Cyanocobalamin. 2007. Available at: www.hcsc.gc.ca. Accessed May 21, 2015. 26 Padayatty JS, Katz A. Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. J Am Coll Nutr. 2003;22(1):1835. 27 Carr AC, Frei B, Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in human. Am J Clin Nutr. 1999;69:1086–107. 28 Health Canada. Natural Health Products Directorate. Product Monographs. Vitamin C. 2007. Available at: www.hc-sc.gc.ca Accessed Jan 4, 2011. 15 Planton J, Meyer JO, Edlund 29 National Institutes of Health. Dietary Supplement Fact Sheet: Vitamin C. http://ods.od.nih.gov/factsheets/VitaminC-Health Professional. 30 Groff J. & Gropper S. (2000). Advanced Nutrition and Human Metabolism, 3rd edition. Wadsworth/ Thomson Learning. F OR PROFESSIONAL U SE O NLY F OR P ROFESSIONALS TO RECEIVE A PRINTED COPY OF THIS MONOGRAPH , CONTACT HERBAL M AGIC CLINICAL SUPPORT AT [email protected] OR 1-866-787-0050. 11/09/15 Rev 0 3 of 3