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Benazepril HCL client counselling information What’s it used for? Benazepril HCL is commonly used by veterinarians to treat heart failure, valvular heart diseases and left to right shunts, hypertension, chronic renal failure and protein losing nephropathies. Dogs Benazepril HCL is used as an adjunctive treatment for hypertension, heart failure, chronic renal failure, protein losing nephropathies, valvular heart disease, and left-to-tight shunts. Cats Benazepril HCL is used as an adjunctive treatment for hypertension, heart failure, chronic renal failure, protein losing nephropathies, valvular heart disease, and left-to-tight shunts. How does it work? Benazepril HCL is an ACE inhibitor. It acts to block the Angiotensin-Converting Enzyme (ACE) from converting Angiotensin I to Angiotensin II. This effectively reduces the concentration of angiotensin II in the body. Angiotensin II acts to increase systemic blood pressure via 2 mechanisms: • Systemic vasoconstriction (constriction of blood vessels in the body) • Stimulation of aldosterone production (aldosterone is produced in the adrenal glands) Consequently by blocking Angiotensin II production, there is a generalized reduction in systemic vasoconstriction and aldosterone production, causing a drop in systemic blood pressure and vascular resistance. Therefore, there are huge benefits for the drug in treating hypertension and heart failure. Benazepril effectively acts as a systemic vasodilator, opening up the blood vessels throughout the body, reducing blood pressure and easing the workload on the heart. In the kidney, Benazepril HCL effectively acts to reduce protein loss through the kidneys, and is used for this reason. How do I give the medication? • Follow the exact instructions given to you by your veterinarian pertaining to dosing. If you miss a dose, try to give it as soon as you remember or as close to the next dose time as possible. Don’t double dose to make up. • Do not stop giving the medication and don’t change the dosage instructions without consultation with your veterinarian. The dose is specific and minor changes can cause considerable side effects. • Benazapril HCL may be given with or without food. Shop 4, 304 - 318 The Kingsway, Caringbah NSW 2229 Phone (02) 9525 3044 Fax (02) 9542 7645 [email protected] Is there anything I specifically need to know about this medication? • Keep this medication out of reach of children and all pets. If an overdose occurs for any animal, be sure to call your veterinarian immediately as there can be quite severe health risks associated with overdoses. • Caution should be taken, and potential Benazepril shouldn’t be given under the following circumstances: • If your pet has experienced a reaction to the drug in the past • If your pet has underlying kidney, or liver impairment • Animals that are pregnant or lactating • If your pet has an underlying blood disorder • Often vet’s will request blood tests be taken prior to treatment, during commencement of treatment and at throughout the course of the treatment. This is important to ensure that kidney function is maintained. Please listen to your vet and try to be compliant with the instructions. Are there any side effects? The most common adverse effects noted in dogs and cats given Benazepril HCL are focused around the gastro-intestinal system. Symptoms noted include nausea, anorexia, vomiting, and diarrhoea. Very rare side effects which have been described in practice includes: • hypotension (usually noted as lethargy and listlessness) • kidney impairment • hyperkalaemia (high blood potassium levels) • immune mediated reactions – bone marrow suppression and or skin reactions. How do I store the medication? • Store at room temperature in a dry, cool place • Keep away from heat and UV light. • Keep out of reach of children and other pets. Are there any drug interactions I should be aware of? Benazepril HCL can interact with the following medications: • Diuretics or other vasodilators • Potassium or potassium sparing diuretics (eg. Spironolactone) • NSAIDS – Non Steroidal Anti-Inflammatory Drugs Shop 4, 304 - 318 The Kingsway, Caringbah NSW 2229 Phone (02) 9525 3044 Fax (02) 9542 7645 [email protected] What happens if I overdose my pet? Call your veterinarian immediately. This should be considered an emergency situation and it is likely your vet will have you come in immediately. References 1. Plumb, D. (2005). Plumbs Veterinary Drug Handbook 2. Brooks, W. (2007). Benazepril HCL (Lotensin), The Pet Pharmacy, accessed 12 May 2012, www.veterinarypartner.com Shop 4, 304 - 318 The Kingsway, Caringbah NSW 2229 Phone (02) 9525 3044 Fax (02) 9542 7645 [email protected]
