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Avisae OptimALL Nutrition™ bliss™ adaptogen mist Avisae OptimALL Nutrition™ bliss™ adaptogen mist is a unique formula that helps reset your body’s serotonin pathways for improved mood, better sleep and increased focus. Supported by seven patents and a placebo controlled clinical trial, the unique ingredient focuses on rebalancing your serotonin set-point via a proprietary ingredient, Seroctin.* Serotonin is a widespread neurotransmitter in the central nervous system and gastrointestinal tract. It is synthesized from the amino acid tryptophan via a conversion pathway that utilizes Vitamin B6. Serotonin is involved in the control of motility, which enables food to pass through the GI tract. In the brain and central nervous system it is involved in the modulation of mood, appetite and sleep. Avisae OptimALL Nutrition™ bliss™ adaptogen mist delivers its benefits via a simple, flavorless oral spray which can be used at any time of day. Product Features • The effectiveness of bliss™ on sleep has been demonstrated in a clinical trial.* • 52 subjects were randomly assigned in double-blind fashion to receive bliss™ (27 subjects) or a placebo (25 subjects) for 4 weeks. Compared to the placebo group, the Bliss™ group: •Had 8% less Tension •Had 15% less Depression •Had 25% less Irritability •Fell asleep 33% faster •Had 50% better sleep “efficiency” •Had 40% better sleep “quality” •Woke up 30% fewer times each night •Experienced 24% more time in deep REM sleep *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. KEY BENEFITS OptimALL Nutrition™ bliss™ adaptogen mist provides a number of key benefits.* •Improved Mood and Optimism* •Emotional Energy* •Rejuvenated Sleep Patterns* •Sharpened Mental Focus* •Normalized Libido & Sexual Performance* •Lessened Stress & Anxiety* 1 • Made in the U.S.A. according to rigorous FDA GMP standards.* • Free from preservatives, toxins, pesticides and heavy metals.* GLUTEN FREE • Soy Free, Gluten Free, GMO Free, Dairy Free Ingredient Information NON GMO ACTIVE INGREDIENTS: • Proprietary Seroctin blend (zea mays) protected by seven US patents (US Patent Numbers 6667308, 7507731, 7521467, 7521468, 7524877, 7541356 and 7794761.) OTHER INGREDIENTS: SOY FREE • Purified water References Pischon et al., “Recent developments in the treatment of obesity-related hypertension.” PubMed Abstract 12187313; Curr Opin Nephrol Hypertens. 2002 Sep; 11(5): 497-502. Garcia H. L., “Dermatological complications of obesity.” PubMed Abstract 12180897; American Journal of Clinical Dermatology. 2002; 3(7): 497-506. Wang, H. and Ng, T. B., “Hypotensive activity of the pineal indoleamine hormones melatonin, 5-methoxytryptophol and 5-methoxytryptamine.” PubMed Abstract 10752670: Pharmacology Toxicology, 2000 Mar; 86(3): 125-8. Lee H. S., “Tyrosinase inhibitors of Pulsatilla cernua root-derived materials.” PubMed Abstract 11879010: Journal of Agricultural Food Chemistry, 2002 Mar 13; 50(6): 1400-3. Gower, Barbara A. and Berger, Patricia J., “Reproductive Responses of Male Microtus montanus to Photoperiod, Melatonin, and 6-MBOA.” Journal of Pineal Research, 8:297-312, 1990. (Copyright 1990 Munksgaard) Sweat, Floyd W. and Berger, Patricia J., “Uterotropic 6-methoxybenzoxazolinone is an adrenergic agonist and a melatonin analog.” Molecular and Cellular Endocrinology, 57:131-138, 1988. (Copyright 1988 Elsevier Scientific Publishers Ireland. Ltd.) Daya et al., “Effect of 6-Methoxy-2-Benzoxazolinone on the Activities of Rat Pineal N-Acetyltransferase and Hydroxyindole-O-Methyltransferase and on Melatonin Production.” Journal of Pineal Research, 8:57-66, 1990. (Copyright 1990 Munksgaard) Anderson et al., “Effects of Melatonin and 6-Methoxybenzoxazolinone on Photoperiodic Control of Testis Size in Adult Male Golden Hamsters.” Journal of Pineal Research, 5:351-65, 1988. (Copyright 1988 Alan R. Liss, Inc.) Yuwiler et al., “Effects of 6-Methoxy-2-Benzoxazolinone on the Pineal Melatonin Generating System.” The Journal of Pharmacology and Experimental Therapeutics, Volume 233:45-50, 1985. (Copyright 1985 The American Society for Pharmacology and Experimental Therapeutics.) Gower, Barbara A., “Endocrine Effects of the Naturally Occurring Reproductive Stimulant 6Methoxybenzoxazolinone.” Ph.D. Thesis, University of Utah, Salt Lake City, UT, 116 pp. 1990. Butterstein George M. and Schadler, Margaret H., “The Plant Metabolite 6-Methoxybenzoxazolinone Interacts with Follicle-Stimulating Hormone to Enhance Ovarian Growth.” Biology of Reproduction, 39:465-71, 1988. Vaughan, M. K. et al., “Hormonal consequences of subcutaneous 6-methoxy-2-benzoxazolinone pellets or injections in prepubertal male and female rats.” Journals of Reproduction and Fertility Ltd, 83:859-66, 1988. (Copyright 1988 Journals of Reproduction and Fertility, Ltd.) Urbanski, H. F. et al., “Influence of photoperiod and 6-methoxybenzoxazolinone on the reproductive axis of inbred LSH/Ss Lak male hamsters.” Journal of Reproduction and Fertility, Ltd, 90:157-163, 1990. Bjostad, Louis B. and Hibbard, Bruce E., “6-Methoxy-2Benzoxazolinone: A Semiochemical for Host Location by Western Corn Rootworm Larvae.” Journal of Chemical Ecology, Vol. 18, No. 7, pp. 931-944, 1992. (Copyright 1992, Plenum Publishing Company) Mayoral, Ana M. et al., “A High Performance Liquid Chromatography Method for Quantification of DIBOA, DIMBOA, and MBOA from Aqueous Extracts of Corn and Winter Cereal Plants,” Journal Of Liquid Chromatography, Vol. 17, No. 12, pp. 2651-2665, 1994. (Copyright 1994, Marcel Dekker, Inc.) Tanda, Sindiswa Eunice, “The Effect of 6 Methoxy2Benzoxazolinone (6_MBOA) on Indoleamine Regulation and Its Possible Role in Depression”. Thesis, Master of Science in the department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Grahamstown, South Africa. January 2000. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. DAIRY FREE VEGAN NUTS FREE MADE IN USA 2