Download Roxipharm

Roxipharm®
Roxithromycin
Pharmacological information
Mode of action
Roxipharm® (Roxithromycin) is a semisynthetic macrolide antibiotic that acts
as an antibacterial by inhibition of protein synthesis. It has a broad antibacterial
action against many gram - positive and to a lesser extent some gram - negative
bacteria, as well as other organisms including anaerobes, mycoplasma,
mycobacteria, and chlamydiae.
Following oral administration, Roxithromycin is well absorbed. Absorption is
reduced when taken after, but not before, a meal. Small amounts of
Roxithromycin are metabolized in liver and the majority of the dose is excreted
in faeces as unchanged drug and metabolites. The elimination half-life is
reported to range between 8 - 13 hours.
Clinical information
Indications
Roxipharm® is indicated for the treatment of infections caused by
Roxithromycin-sensitive organisms, especially in:
- Lower respiratory tract infections including pneumonia, atypical pneumonia,
chronic obstructive lung disease and bronchitis.
- Upper respiratory tract infections including tonsillitis, pharyngitis, otitis
media and sinusitis.
- Acute or chronic non - gonococcal urethritis, non - gonococcal sexually
transmitted infections and cervicovaginitis.
- Skin and soft tissue infections including pyoderma, infective dermatitis and
leg ulcers.
- Prophylaxis of meningococcal meningitis.
Dosage and administration
Roxipharm® is given by mouth in a dose of 150 mg twice daily before meals,
one tablet in the morning and one tablet in the evening, for the treatment of
susceptible infections.
Contraindications
- Allergy to Roxithromycin or any other related macrolide antibiotic.
- Taking Roxithromycin in combination with Ergotamine
Dihydroergotamine (migrain medications) or Cisapride.
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and
Precautions
In case of prescribing Roxipharm® (Roxithromycin), the following conditions
should be taken into consideration:
- Pregnancy and lactation.
- Hepatic insufficiency.
- The concomitant administration of other drugs particularly bromocriptine.
- Car driving and use of machines may become dangerous because of dizzy
sensation.
Side effects
- Gastro-intestinal disturbances: nausea, vomiting, stomach pain, and diarrhea.
- Transient increase in some liver enzymes (ASAT, ALAT).
- Other side effects including rashes, headaches, dizziness, and weakness.
Pharmaceutical information
How supplies
Roxipharm® F/C tablets: (Roxithromycin) 150mg / tablet
(pack of 10).
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