Esam Z. Dajani, Ph.D., FACG
... Served on the program committees for the European Association of Gastroenterology and Endoscopy, The Interscience World Conference on Inflammation and Chicago Biotech Network. Research Activities/ Clinical Pharmacology, Toxicology and Clinical Development. Interests: Gastrointestinal Pharmacology: ...
... Served on the program committees for the European Association of Gastroenterology and Endoscopy, The Interscience World Conference on Inflammation and Chicago Biotech Network. Research Activities/ Clinical Pharmacology, Toxicology and Clinical Development. Interests: Gastrointestinal Pharmacology: ...
Prokinetic agents: current aspects with focus on cisapride
... gastrointestinal tract. In larger dosages it exhibits neuroleptic action as well.1,18 The pharmacodynamic potency of metoclopramide and its extrapyramidal unwanted effects are due to its antagonistic action on dopaminergic receptors in the Central Nervous System (C.N.S.). This action is not detected ...
... gastrointestinal tract. In larger dosages it exhibits neuroleptic action as well.1,18 The pharmacodynamic potency of metoclopramide and its extrapyramidal unwanted effects are due to its antagonistic action on dopaminergic receptors in the Central Nervous System (C.N.S.). This action is not detected ...
Lower Pediatric Oral Bioavailability of Voriconazole is Not Due to
... and 4.8 minutes for the voriconazole N-oxide. Peak areas were measured at 265 nm for diclofenac sodium and voriconazole N-oxide, and at 254 nm for voriconazole. ...
... and 4.8 minutes for the voriconazole N-oxide. Peak areas were measured at 265 nm for diclofenac sodium and voriconazole N-oxide, and at 254 nm for voriconazole. ...
Evaluation of the use of static and dynamic models to predict drug
... Clinical pharmacokinetic and drug interaction data Intravenous (iv) PK data were obtained from Phase I studies. Clinical PK parameters obtained from study reports were calculated using compartmental or non-compartmental analysis. Metabolic clearance was estimated by subtracting any measured renal cl ...
... Clinical pharmacokinetic and drug interaction data Intravenous (iv) PK data were obtained from Phase I studies. Clinical PK parameters obtained from study reports were calculated using compartmental or non-compartmental analysis. Metabolic clearance was estimated by subtracting any measured renal cl ...
Polyethylene Glycol 3350 (PEG 3350) Frequently Asked
... non-toxic and has no effect on the body. It is used in many products including medications such as ointments and pills to allow them to be more easily dissolved in water. PEG can also be found in common household products such as certain brands of skin creams and tooth paste. PEG 3350 is the most co ...
... non-toxic and has no effect on the body. It is used in many products including medications such as ointments and pills to allow them to be more easily dissolved in water. PEG can also be found in common household products such as certain brands of skin creams and tooth paste. PEG 3350 is the most co ...
Gastrointestinal bleeding with the new oral anticoagulants â
... 4. Compared with warfarin, apixaban does not significantly alter the risk of major GI bleeding. 5. Compared with warfarin, dabigatran 110 mg twice daily does not significantly alter the risk of major GI bleeding. 6. Concurrent use of anti-platelet agents increases the risk of major GI bleeding assoc ...
... 4. Compared with warfarin, apixaban does not significantly alter the risk of major GI bleeding. 5. Compared with warfarin, dabigatran 110 mg twice daily does not significantly alter the risk of major GI bleeding. 6. Concurrent use of anti-platelet agents increases the risk of major GI bleeding assoc ...
Full Text PDF - International Journal of ChemTech Research
... normally protects the esophagus, stomach and duodenum from gastric acid and pepsin. 1 The pathogenesis of gastric ulcers due to weak defense of mucosal tissue, is caused by large quantities of gastric acid. During most of the day, the food can stimulate gastric acid secretion also neutralize gastric ...
... normally protects the esophagus, stomach and duodenum from gastric acid and pepsin. 1 The pathogenesis of gastric ulcers due to weak defense of mucosal tissue, is caused by large quantities of gastric acid. During most of the day, the food can stimulate gastric acid secretion also neutralize gastric ...
Manuscript_12122012_revised
... in different segments of the rat intestine; jejunum, ileum and colon. To assess whether TDM causes damage to intestinal epithelia in vitro, TDM was evaluated by lactate dehydrogenase (LDH) assay in Caco-2 and E12 monolayers. Furthermore, tissues from the in situ experiments were assessed histologica ...
... in different segments of the rat intestine; jejunum, ileum and colon. To assess whether TDM causes damage to intestinal epithelia in vitro, TDM was evaluated by lactate dehydrogenase (LDH) assay in Caco-2 and E12 monolayers. Furthermore, tissues from the in situ experiments were assessed histologica ...
What is the nutrient? Selenium. What is the RDA/DRI for the nutrient
... What disease states alter the nutrients metabolism? ...
... What disease states alter the nutrients metabolism? ...
Gastric Residuals in Neonates: Evidence-Based Practice
... gestational age preterm infants was conducted. Gastric residuals were measured at 1 hours and 3 hours after the initiation of the feeding. The results of their study showed at 1 hour, right lateral decubitus led to less significant residuals than left lateral decubitus (p=0.029). The prone position ...
... gestational age preterm infants was conducted. Gastric residuals were measured at 1 hours and 3 hours after the initiation of the feeding. The results of their study showed at 1 hour, right lateral decubitus led to less significant residuals than left lateral decubitus (p=0.029). The prone position ...
Pharmacologic Identification of the Lower Esophageal Sphincter
... attributed to a preponderance of striated muscle in the proximal strips. In the cat, striated muscle may extend down to 3 or 4 cm above the stomach. The possibility that there is a difference defining the sphincter independent of the type of muscle making up the muscular wall can only be tested in a ...
... attributed to a preponderance of striated muscle in the proximal strips. In the cat, striated muscle may extend down to 3 or 4 cm above the stomach. The possibility that there is a difference defining the sphincter independent of the type of muscle making up the muscular wall can only be tested in a ...
DRUG ENCAPSULATION IN PECTIN HYDROGEL BEADS- A SYSTEMATIC STUDY OF
... molecules form so-called calcium “egg boxes” when at least nine non-esterified galacturonic acid residues are present in sequence. A monoclonal antibody (2F4) that specifically binds this supramolecular conformation has been described 5. De-esterified pectin can be chemically converted to carboxamid ...
... molecules form so-called calcium “egg boxes” when at least nine non-esterified galacturonic acid residues are present in sequence. A monoclonal antibody (2F4) that specifically binds this supramolecular conformation has been described 5. De-esterified pectin can be chemically converted to carboxamid ...
Mesenteric and peritoneal anatomy
... His descriptions were first presented in a series of classic lectures and thereafter integrated in most reference anatomic, embryologic, surgical, and radiologic texts [1–11]. Treves laid esenteric and peritoneal anatdown his understanding of m omy at a time when anatomic descriptions were providi ...
... His descriptions were first presented in a series of classic lectures and thereafter integrated in most reference anatomic, embryologic, surgical, and radiologic texts [1–11]. Treves laid esenteric and peritoneal anatdown his understanding of m omy at a time when anatomic descriptions were providi ...
University of Groningen Human and rat organ slices de
... separately. The fact that tissue slices can be seen as small ‘intact’ organs allow us to look at toxicity parameters, as described in § 7, after exposure to potential drug candidates. Performing these experiments, using different species and/or organs, in combination with metabolite profiles of the ...
... separately. The fact that tissue slices can be seen as small ‘intact’ organs allow us to look at toxicity parameters, as described in § 7, after exposure to potential drug candidates. Performing these experiments, using different species and/or organs, in combination with metabolite profiles of the ...
SODIUM POLYSTYRENE SULFONATE Suspension, USP
... mL of sodium polystyrene sulfonate suspension contains 1575 mg (68.5 mEq) per 60 mL which is equivalent to 1500 mg on the anhydrous basis of sodium. Since the in-vivo efficiency of sodiumpotassium exchange resins is approximately 33%, about one-third of the resin’s actual sodium content is being del ...
... mL of sodium polystyrene sulfonate suspension contains 1575 mg (68.5 mEq) per 60 mL which is equivalent to 1500 mg on the anhydrous basis of sodium. Since the in-vivo efficiency of sodiumpotassium exchange resins is approximately 33%, about one-third of the resin’s actual sodium content is being del ...
... We would like to extend a warm word of thanks to you for acquiring this Report. The reason why we have decided to share the contents in this Report with you is quite simply because we are innately compassionate and truly do care about your health and wellbeing. Furthermore, we have witnessed an alar ...
An investigation of the effects of fulvic and humic acids... the absorption of selected drugs, vitamins and minerals
... for each test compound was noted, the extent of the absorption increase or decrease was compound specific. The changes in absorption observed could be attributed to changes in compound solubility and mechanism of transport across the intestinal membrane once in complex. Drugs and vitamins were seen ...
... for each test compound was noted, the extent of the absorption increase or decrease was compound specific. The changes in absorption observed could be attributed to changes in compound solubility and mechanism of transport across the intestinal membrane once in complex. Drugs and vitamins were seen ...
Assessing the Plasma Pharmacokinetics, Tissue Distribution
... (Intralipid), the area under [3H]cholesterol concentration versus time curve and maximum plasma concentration of [3H]cholesterol were decreased in a dosedependent manner (7). An explanation for these findings may be due to the inhibition or displacement of cholesterol from cholesterol-containing mic ...
... (Intralipid), the area under [3H]cholesterol concentration versus time curve and maximum plasma concentration of [3H]cholesterol were decreased in a dosedependent manner (7). An explanation for these findings may be due to the inhibition or displacement of cholesterol from cholesterol-containing mic ...
Effect of cranberry dietary supplements with
... zymes metabolize 90 % of clinically used drugs (Guengerich, 1999; Lynch and Price, 2007). CYP plays an important role in detoxification and the elimination of many drugs and other xenobiotics including carcinogens. Human CYP3A4 is the most important human CYP isozyme because it is involved in the me ...
... zymes metabolize 90 % of clinically used drugs (Guengerich, 1999; Lynch and Price, 2007). CYP plays an important role in detoxification and the elimination of many drugs and other xenobiotics including carcinogens. Human CYP3A4 is the most important human CYP isozyme because it is involved in the me ...
Atlas of Signs and Findings in Crohns Disease
... Investigations of Our Patient • CT scan done outside, 5 years ago, showed inflammation in the proximal transverse colon, with focal microperforations and some abnormal thickening of the terminal ileum • A repeat CT scan showed an ileocecal fistula • Colonoscopy, 5 years back, showed a single aphthou ...
... Investigations of Our Patient • CT scan done outside, 5 years ago, showed inflammation in the proximal transverse colon, with focal microperforations and some abnormal thickening of the terminal ileum • A repeat CT scan showed an ileocecal fistula • Colonoscopy, 5 years back, showed a single aphthou ...
Full-Text PDF
... Nitrofurantoin is, overall, a relatively safe drug. The overall experience after more than three decades of extensive use shows a very low reported side-effect incidence of less than 0.001 per cent based on total courses of therapy [12–14]. However, adverse reactions described, mainly related to lon ...
... Nitrofurantoin is, overall, a relatively safe drug. The overall experience after more than three decades of extensive use shows a very low reported side-effect incidence of less than 0.001 per cent based on total courses of therapy [12–14]. However, adverse reactions described, mainly related to lon ...
Duspatal/Duspatal Retard
... Mebeverine is rapidly absorbed after oral doses with peak plasma concentrations occurring in 1 to 3 hours. It is 75% bound to albumin in plasma. Mebeverine is completely metabolised by hydrolysis to veratric acid and mebeverine alcohol, the latter of which may then be conjugated. The metabolites are ...
... Mebeverine is rapidly absorbed after oral doses with peak plasma concentrations occurring in 1 to 3 hours. It is 75% bound to albumin in plasma. Mebeverine is completely metabolised by hydrolysis to veratric acid and mebeverine alcohol, the latter of which may then be conjugated. The metabolites are ...
Prescribing Information
... of soft, well formed stools. 2) Increased osmotic pressure of fecal material secondary to an increase in colonic organic acids results in accumulation of fluid from surrounding tissues, helping to soften stool mass. The therapeutic action of lactulose in ameliorating the symptoms of hepatic encephal ...
... of soft, well formed stools. 2) Increased osmotic pressure of fecal material secondary to an increase in colonic organic acids results in accumulation of fluid from surrounding tissues, helping to soften stool mass. The therapeutic action of lactulose in ameliorating the symptoms of hepatic encephal ...