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Infection and it’s mode of transmission: SOURCE OF INFECTION It is defined as the person, animal, object or substance from which an infectious agent passes or is disseminated to the host RESERVOIR: ► It is defined as “any person, animal, arthropod, plant, soil, or substance “(or combination of these in which an infectious agent lives and multiplies, on which it depends primarily for survival, and where it reproduces itself in such manner that it can be transmitted to a susceptible host” CARRIERS: A Carrier is defined as an infected person or animal that harbours a specific infectious agent in the absence of discernible clinical disease and serves as a potential source of infection for others A) Incubatory ► TYPE B) Convalescent C) Healthy ► DURATION A) Temporary B) Chronic PORTAL OF EXIT: A) Urinary B) Intestinal C) Respiratory ► 1. 2. 3. 4. FEATURES OF CARRIER: Presence of specific microbes in the body Absence of apparent symptoms and signs Shedding of micro-organisms in the discharges or excretions As a source of infection to others INCUPATION PERIOD: ► The time interval between invasion by an infectious agent and appearance of the first sign or symptom of the disease in question FACTORS TO DETERMINE THE INCUBATION PERIOD: ► Infective dose ► Portal of entry 1 ► Individual susceptibility COMMUNICABLE PERIOD: It is defined as the time during which an infectious agent may be transferred directly or indirectly from an infected person to another person, from an infected animal to man , or from an infected person to an animal, including arthropods HERD IMMUNITY: It is the level of resistance of a community or group of people to a particular disease BEHAVIOUR OF DISEASE IN THE COMMUNITY: 1. Exotic 2. Sporadic 3. Endemic 4. Epidemic 5. Pandemic 6. Outbreak EPIDEMIC: ► It is the unusual occurrence in a community or region of cases of an illness, specific health-related behavior, or other health related events clearly in excess of normal expectancy (LAST,1995) OUT BREAK: ► Two or more related cases in infections, suggesting the possibility of a common source or transmission between cases EPIDEMIOLOGY OF DISEASE: ► ► ► ► ► ► ► ► ► ► ► Place Time Distribution Agent determinants Host determinants Environmental determinants Incupation period Mode of transmission Portal of entry Natural history of disease Secondary attack rate 6 Links to the Chain of Infection: ► Portal of Entry ► Susceptible Host ► Causative Agent 2 ► ► ► Reservoir Portal of Exit Mode of Transmission 1. Causative Agent: ► Bacteria (includes Richettsia, Chlamydia, and Mycoplasm ► Viruses ► Fungi ► Protozoa ► Helminths 2 Reservoir: ► Humans: ► Patients ► Healthcare Workers ► Animals ► Insects ► Rodents ► Shell Fish ► Environment ► Patient Care Equipment ► Environmental Surfaces ► Food 3 Portal of Exit: The path by which the infectious organism (agent) leaves the reservoir 4 Modes of Transmission: ► Contact (Direct and Indirect) ► Airborne ► Vector-Borne ► Common Vehicle CONTACT: ► DIRECT: immediate transmission ► Person-to-person ► Actual physical contact between source and patient ► INDIRECT CONTACT: ► Patient to contaminated indirect object (contaminated endoscope) ► Droplets spread (large particles that rapidly settle out on horizontal surfaces – usually within 3 feet of source) ► AIRBORNE ► Organisms contained within droplet nuclei or dust particles (i.e. droplet nuclei of tuberculosis 3 ► Suspended in air for extended periods, may be spread through ventilation systems ► VECTOR-BORN: ► External vector-born transmission; mechanical transfer of microbes on external appendages (feet of flies) ► Harbored by Vector ► Harbored by vector, but no biological interaction between vector and agent (i.e. yellow fever virus PORTAL OF ENTRY: The path by which an infectious agent enters the susceptible host Recommendations isolation precautions: ► ► ► ► ► Birth of Infectious Disease Hospitals Patients with infectious disease process placed in separate facilities Aseptic techniques used to combat transmission of diseases ► Barrier Nursing: ► Hospital personnel wear gowns between patients ► Handwashing between patients with antiseptic solutions after patient contact ► Disinfection of objects contaminated by patents 7 Categories of Isolation: ► Strict Isolation ► Respiratory Isolation ► Protective Isolation ► Enteric Isolation ► Wound and Skin Precautions ► Discharge Precautions ► Blood Precautions ► Disease were lumped into categories based on epidemiological features of the disease (resulted in under or over isolation) ► ► ► ► ► ► Respiratory Bone and Joint Infection Central Nervous System Gastrointestinal System Skin and Soft Tissue Surgical Sites 4 ► ► ► ► ► Blood Stream Urinary System (UTI) Cardiovascular Eye/Ear/Throat Mouth Infection Reproductive System 3 Major Modes of Transmission in the Healthcare Setting: ► Skin Contact ► Puncture Wounds ► Mucous Membranes (eye/mouth/nose) Bloodborne Pathogens: ► Hepatitis B Virus ► Hepatitis C Virus ► Human Immunodeficiency Virus 5