* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Catalytic Nitrene Transfer onto Isocyanide by a Redox
Survey
Document related concepts
Deoxyribozyme wikipedia , lookup
Microbial metabolism wikipedia , lookup
Paracrine signalling wikipedia , lookup
Light-dependent reactions wikipedia , lookup
Signal transduction wikipedia , lookup
Multi-state modeling of biomolecules wikipedia , lookup
Photosynthetic reaction centre wikipedia , lookup
Drug design wikipedia , lookup
Free-radical theory of aging wikipedia , lookup
Electron transport chain wikipedia , lookup
Evolution of metal ions in biological systems wikipedia , lookup
Oxidative phosphorylation wikipedia , lookup
Metalloprotein wikipedia , lookup
NADH:ubiquinone oxidoreductase (H+-translocating) wikipedia , lookup
Transcript
Catalytic Nitrene Transfer onto Isocyanide by a Redox-Active Ligand Zirconium Complex Andy I. Nguyen Mentor: Alan Heyduk In an effort to bridge the gap between late- and early-metal reactivity, we have used redox-active ligands that are capable of multielectron valence changes. These ligands on formally d0 metal centers have been shown to facilitate “oxidative addition” of halogens and reductive coupling of C-C and N=N bonds. Recently, we have used these ligands on tantalum(V) to generate imido complexes from organic azides(REF). This work reports the reactivity of a zirconium(IV) complex with the previously reported [NNNcat]3- (bis(2-isopropylamino-4methoxyphenylamine)) redox-active ligand. Successive oxidation of [NNNcat]ZrCl(thf)2 by chlorine establishes the availability of one- and two- electron oxidative states. The complex [NNNcat]ZrCl(CNtBu)2, formed by ligand exchange of tetrahydrofuran with tert-butyl isocyanide, is able to catalyze the oxidative C=N coupling of isocyanide and azide via a transient zirconium imido species.