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Fast and simple way to produce a study guide Copy any slide and alter it to develop a self test On the slide that was copied, place shaded squares or rectangles or any geometric figures to hide useful information. The shaded figures in row A can be copied using Mac or PC commands that are outlined on the next slide. That next slide shows how to make multiple of copies of a given geometric figure as shown in row B. Now place shaded figures over parts of the copied slide to cover up “useful” information to develop your self test. 1.Row A. 1.Row B. 2.See how this is done in examples A-E. How do I Cut, Copy, and Paste with a Mac? On a Mac computer, the Command key is generally located adjacent to the spacebar and is often labeled with a ⌘ symbol that resembles a four leaf clover. The following key combinations require that you first press and hold the Command key, while proceeding to press the letter assigned to the Copy, Cut or Past function. To Copy with a Mac, use the following key combination: Command + C To Cut with a Mac, use the following key combination: Command + X To Paste with a Mac, use the following key combination: Command + V PC method Actions: Mouse method: Mouse and keyboard method: Copy Highlight, right click, copy Highlight, Ctrl, c Cut Highlight, right click, cut Highlight, Ctrl, x Paste Highlight, right click, paste Highlight, Ctrl, v Example A Structure of an antibody molecule A The seven areas (A-F) of the antibody molecules are as follows: NH2 NH2 NH2 NH2 B C F CL COOH CH1 CH1 CL D= Fc region E= Interchain disulfide bonds -S-S- -S-S- COOH CH2 CH2 F=Fab region D CH3 COOH E CH3 COOH A= Fv region B= Framework region C= Complementarity determining regions (CDRs) Not shown in the diagram are intrachain disulfide bonds which are present in each of the 12 domain of the antibody molecule Two light chains and each with two domains Two heavy chains and each with four domains 4 Self-Test Study the unaltered slide for 30 minutes. Now take the self test with the altered slide to see if you can remember what information on the altered slide is hidden. To verify your response click and remove the blue shaded rectangles and squares to see the hidden information. See the attached powerpoint slides to allow you to do such an operation. Now return the shaded rectangles to the same or different position on the slide for future testing Structure of an antibody molecule with covered sections A NH2 NH2 NH2 To Identify hidden information. Click and lift to see answers. NH2 B C F CL COOH CH1 CH1 CL COOH CH2 C= Complementarity determining regions (CDRs) CH2 D CH3 CH3 A= Fv region B= Framework region -S-S- -S-S- The shaded rectangles can be moved to cover information on different sections of the antibody molecule to generate new self-tests D= Fc region E= Interchain disulfide bonds COOH E COOH F=Fab region 6 Example B Structure of an antibody molecule A NH2 NH2 NH2 In Man five different classes of antibody molecules are present with seven similar regions NH2 B C F A= Fv region B= Framework region C= Complementarity determining regions (CDRs) D= Fc region E= Interchain disulfide bonds CL COOH CH1 CH1 CL F=Fab region -S-S- -S-S- The five classes are easily remembered with the word “GAMED” COOH CH2 CH2 D CH3 COOH E CH3 COOH G = IgG A = IgA M = IgM E = IgE D = IgD 8 Self-Test Study the unaltered slide for 30 minutes. Now take the self test with the altered slide to see if you can remember what information on the altered slide is hidden. To verify your response click and remove the blue shaded rectangles and squares to see the hidden information. See the attached powerpoint slides to allow you to do such an operation. Now return the shaded rectangles to the same or different position on the slide for future testing Structure of an antibody molecule with hidden information A NH2 NH2 NH2 In Man five different classes of antibody molecules are present with seven similar regions NH2 B C F A= Fv region B= Framework region C= Complementarity determining regions (CDRs) D= Fc region E= Interchain disulfide bonds CL COOH CH1 CH1 CL F=Fab region -S-S- -S-S- The five classes are easily remembered with the word “GAMED” COOH CH2 CH2 D CH3 COOH E CH3 COOH G = IgG A = IgA M = IgM E = IgE D = IgD 10 Example C Original and Not Altered The immune system consists of organs, tissues and cells, as well as soluble and integral membrane proteins. The system itself can be diabolical, that is, it protects the host from potential pathogenic agents, is important in inflammation and in some cases initiates autoimmune diseases and other disorders. A vital component of the immune system are a collection of proteins that are needed to complete antibody antigen reactions and are known as complement proteins. In fact, the complement system consists of classical, alternative, and lectin pathways. Each pathway in the complement system is important in destroying disease producing agents and in tissue repair. However, the enzymes of the complement system must also be controlled to prevent nonspecific damage to host tissues and cells that can lead to disease. Self-Test Study the unaltered slide for 30 minutes. Now take the self test with the altered slide to see if you can remember what information on the altered slide is hidden. To verify your response click and remove the blue shaded rectangles and squares to see the hidden information. See the attached powerpoint slides to allow you to do such an operation. Now return the shaded rectangles to the same or different position on the slide for future testing Altered The immune system consists of organs, tissues and cells, as well as soluble and integral membrane proteins. The system itself can be diabolical, that is, it protects the host from potential pathogenic agents, is important in inflammation and in some cases initiates autoimmune diseases and other disorders. A vital component of the immune system are a collection of proteins that are needed to complete antibody antigen reactions and are known as complement proteins. In fact, the complement system consists of classical, alternative, and lectin pathways. Each pathway in the complement system is important in destroying disease producing agents and in tissue repair. However, the enzymes of the complement system must be controlled to prevent nonspecific damage to host tissues and cells that can lead to disease.