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Job description and selection criteria Job title Postdoctoral Research Scientist Division Medical Sciences Department Sir William Dunn School of Pathology Location South Parks Rd Oxford OX1 3RE Grade and salary Grade 7: £29.099 - £35,788 Hours Full time Contract type Fixed term Reporting to Dr Monika Gullerova Vacancy reference Additional information Introduction The University The University of Oxford is a complex and stimulating organisation, which enjoys an international reputation as a world-class centre of excellence in research and teaching. It employs over 10,000 staff and has a student population of over 21,000. Most staff are directly appointed and managed by one of the University’s 130 departments or other units within a highly devolved operational structure - this includes 5,900 ‘academicrelated’ staff (postgraduate research, computing, senior library, and administrative staff) and 2,820 ‘support’ staff (including clerical, library, technical, and manual staff). There are also over 1,600 academic staff (professors, readers, lecturers), whose appointments are in the main overseen by a combination of broader divisional and local faculty board/departmental structures. Academics are generally all also employed by one of the 38 constituent colleges of the University as well as by the central University itself. Our annual income in 2009/10 was £879.8m. Oxford is one of Europe's most innovative and entrepreneurial universities: income from external research contracts exceeds £367m p.a., and more than 60 spin-off companies have been created. For more information please visit www.ox.ac.uk For more information please visit: http://www.division.ox.ac.uk/ Department The Sir William Dunn School of Pathology is one of the largest science Departments in the University of Oxford, employing around 300 people. It teaches physiology and medicine to undergraduates and has an extensive research programme covering bacteriology and virology, cell biology, immunology and molecular biology. The Dunn School is famous for pioneering work on penicillin, which brought in the antibiotic era. The Department has recently (Jan 2011) seen the completion of a major new building project - the new Oxford Molecular Pathology Institute (OMPI). This £30 million Institute houses programmes in immunology, molecular developmental biology, microbiology, and cancer cell biology. For more information please visit: http://www.path.ox.ac.uk Current Research in MG lab We are interested in mechanistic details of transcriptional gene silencing in normal and disease cells. We use mammalian cell culture for these studies and employ a wide range of molecular technologies including both single gene and genomic analysis of gene expression, investigated at the chromatin, pre-mRNA, mRNA and protein levels. Both cis mutation of critical sequence elements as well as gene knock down by RNA approaches are employed. Project: Transcriptional regulation and dynamics of ERBB2 amplicon in breast cancer cells. Overexpression of human epithelial growth factor receptor HER2 (ERBB2 gene) occurs in 15-25% of invasive breast cancers. ERBB2 is a part of an amplicon, a group of several genes on chromosome 17, which are co-expressed in cancer cells. What regulates transcription of this amplicon is not well understood, but essential for the design of efficient therapy. For more details please: http://www.path.ox.ac.uk/dirsci/molbiology/gullerova Job description Research topic Transcriptional architecture of ERBB2 amplicon. Principal Investigator / supervisor Monika Gullerova Project web site http://www.path.ox.ac.uk/dirsci/molbiology/gullerova Funding partner The funds supporting this research project are provided by the Medical Research Council Technical skills Gene expression methodologies; Genomis; Overview of the role This position is available from the first half of 2013 in the research laboratory of Dr Monika Gullerova to study the Transcriptional regulation and dynamics of ERBB2 amplicon in breast cancer cells. Applications for this advanced and technically challenging research position will require prior expertise in a range of molecular and cell biology technologies. Selection criteria Essential A PhD or equivalent Mammalian molecular biology skills including cloning, sequencing and cell culture techniques Protein analysis techniques Nuclear fractionation techniques Chromatin analytic technology, including ChIP RNA protein complex analysis, including co-immunoprecipitation, ChIP and RIP analysis. Transcription analysis including Northern blotting and real time RT/PCR. Genomic analyses including microarray and massive sequencing technologies Preferred Genomic analyses including microarray and massive sequencing technologies Bioinformatics Working at the University of Oxford For further information about working at Oxford, please see: http://www.ox.ac.uk/about_the_university/jobs/research/ How to apply If you consider that you meet the selection criteria, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a user. You will then be required to complete a number of screens with your application details, relating to your skills and experience. When prompted, please provide details of two three referees and indicate whether we can contact them at this stage. You will also be required to upload a CV and supporting statement. The supporting statement should describe what you have been doing over at least the last 10 years. This may have been employment, education, or you may have taken time away from these activities in order to raise a family, care for a dependant, or travel for example. Your application will be judged solely on the basis of how you demonstrate that that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education. Please save all uploaded documents to show your name and the document type. All applications must be received by midday on the closing date stated in the online advertisement. Should you experience any difficulties using the online application system, please email [email protected] To return to the online application at any stage, please click on the following link www.recruit.ox.ac.uk Please note that you will be notified of the progress of your application by automatic e-mails from our e-recruitment system. Please check your spam/junk mail regularly to ensure that you receive all e-mails.