Download Job description and selection criteria

Job description and selection criteria
Job title
Postdoctoral Research Scientist
Division
Medical Sciences
Department
Sir William Dunn School of Pathology
Location
South Parks Rd Oxford OX1 3RE
Grade and salary
Grade 7: £29.099 - £35,788
Hours
Full time
Contract type
Fixed term
Reporting to
Dr Monika Gullerova
Vacancy reference
Additional
information
Introduction
The University
The University of Oxford is a complex and stimulating organisation, which enjoys an
international reputation as a world-class centre of excellence in research and teaching. It
employs over 10,000 staff and has a student population of over 21,000.
Most staff are directly appointed and managed by one of the University’s 130 departments or
other units within a highly devolved operational structure - this includes 5,900 ‘academicrelated’ staff (postgraduate research, computing, senior library, and administrative staff) and
2,820 ‘support’ staff (including clerical, library, technical, and manual staff). There are also
over 1,600 academic staff (professors, readers, lecturers), whose appointments are in the
main overseen by a combination of broader divisional and local faculty board/departmental
structures. Academics are generally all also employed by one of the 38 constituent colleges
of the University as well as by the central University itself.
Our annual income in 2009/10 was £879.8m. Oxford is one of Europe's most innovative and
entrepreneurial universities: income from external research contracts exceeds £367m p.a.,
and more than 60 spin-off companies have been created.
For more information please visit www.ox.ac.uk
For more information please visit: http://www.division.ox.ac.uk/
Department
The Sir William Dunn School of Pathology is one of the largest science Departments in the
University of Oxford, employing around 300 people. It teaches physiology and medicine to
undergraduates and has an extensive research programme covering bacteriology and
virology, cell biology, immunology and molecular biology. The Dunn School is famous for
pioneering work on penicillin, which brought in the antibiotic era.
The Department has recently (Jan 2011) seen the completion of a major new building project
- the new Oxford Molecular Pathology Institute (OMPI). This £30 million Institute houses
programmes in immunology, molecular developmental biology, microbiology, and cancer cell
biology.
For more information please visit: http://www.path.ox.ac.uk
Current Research in MG lab
We are interested in mechanistic details of transcriptional gene silencing in normal
and disease cells. We use mammalian cell culture for these studies and employ a
wide range of molecular technologies including both single gene and genomic
analysis of gene expression, investigated at the chromatin, pre-mRNA, mRNA and
protein levels. Both cis mutation of critical sequence elements as well as gene knock
down by RNA approaches are employed.
Project: Transcriptional regulation and dynamics of ERBB2 amplicon in breast
cancer cells.
Overexpression of human epithelial growth factor receptor HER2 (ERBB2 gene)
occurs in 15-25% of invasive breast cancers. ERBB2 is a part of an amplicon, a
group of several genes on chromosome 17, which are co-expressed in cancer cells.
What regulates transcription of this amplicon is not well understood, but essential for
the design of efficient therapy.
For more details please: http://www.path.ox.ac.uk/dirsci/molbiology/gullerova
Job description
Research topic
Transcriptional architecture of ERBB2 amplicon.
Principal Investigator
/ supervisor
Monika Gullerova
Project web site
http://www.path.ox.ac.uk/dirsci/molbiology/gullerova
Funding partner
The funds supporting this research project are provided by the
Medical Research Council
Technical skills
Gene expression methodologies; Genomis;
Overview of the role
This position is available from the first half of 2013 in the research laboratory of Dr Monika
Gullerova to study the Transcriptional regulation and dynamics of ERBB2 amplicon in breast
cancer cells.
Applications for this advanced and technically challenging research position will require prior
expertise in a range of molecular and cell biology technologies.
Selection criteria
Essential
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A PhD or equivalent
Mammalian molecular biology skills including cloning, sequencing and cell culture
techniques
Protein analysis techniques
Nuclear fractionation techniques
Chromatin analytic technology, including ChIP
RNA protein complex analysis, including co-immunoprecipitation, ChIP and RIP
analysis.
Transcription analysis including Northern blotting and real time RT/PCR.
Genomic analyses including microarray and massive sequencing technologies
Preferred
 Genomic analyses including microarray and massive sequencing technologies
 Bioinformatics
Working at the University of Oxford
For further information about working at Oxford, please see:
http://www.ox.ac.uk/about_the_university/jobs/research/
How to apply
If you consider that you meet the selection criteria, click on the Apply Now button on the
‘Job Details’ page and follow the on-screen instructions to register as a user. You will then
be required to complete a number of screens with your application details, relating to your
skills and experience. When prompted, please provide details of two three referees and
indicate whether we can contact them at this stage. You will also be required to upload a CV
and supporting statement. The supporting statement should describe what you have been
doing over at least the last 10 years. This may have been employment, education, or you
may have taken time away from these activities in order to raise a family, care for a
dependant, or travel for example. Your application will be judged solely on the basis of how
you demonstrate that that you meet the selection criteria outlined above and we are happy to
consider evidence of transferable skills or experience which you may have gained outside
the context of paid employment or education.
Please save all uploaded documents to show your name and the document type.
All applications must be received by midday on the closing date stated in the online
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Should you experience any difficulties using the online application system, please email
[email protected]
To return to the online application at any stage, please click on the following link
www.recruit.ox.ac.uk
Please note that you will be notified of the progress of your application by automatic e-mails
from our e-recruitment system. Please check your spam/junk mail regularly to ensure that
you receive all e-mails.