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Process of Evolution Wednesday, February 18th • What do you think the term microevolution means? What do you believe some of the causes for microevolution are? Monday, February 23rd • In a population, if no mutations occurred in the individuals what do you think would happen in the gene pool of the succeeding generations? Tuesday, February • th 24 If a population if 36% of the individuals are homozygous dominant, what % of the population has the recessive phenotype, assuming HardyWeinberg equilibrium? Wednesday, February • th 25 Of the 5 conditions of H-W equilibrium, which could cause the greatest change in a population if it were applied? Why? See your notes if you don’t remember the 5 conditions! Thursday, February • th 26 In natural selection, there are three types of selection that occur, one of those being directional selection. What do you think is occurring in a population with this type of selection. Friday, February • th 27 Would you like the idea of preparing for the AP test outside of class? What days and times would you be willing to attend? Evolution in a Genetic Context • Darwin knew that members of a population varied but he did not know how variations came about and they were transmitted in populations • Around the 1930s, geneticists were able to apply concepts of genetics to Darwin’s idea of populations • We now recognize this as a way that evolution has occurred • Population: all members of a single species occupying a particular area at the same time • Microevolution: Evolution that occurs within a population • Population Genetics: study of gene frequencies in and their changes within a population • Gene Pool: total of all genes of all the individuals in a population Allele Frequencies • It is customary to describe the gene pool of a population in terms of gene frequencies • To calculate the frequency of each allele, you must have the # of each genotype (homo dominant, heterozygous, homo recessive) & the total # of individuals of a population ozygous dominant for red eyes, 1/2 are heterozygous and 1/4 hom at is the number of the allele R and the allele r in the populati Hardy-Weinberg Law • Because of the result of calculating the frequency of alleles, we can determine that sexual reproduction ALONE cannot bring about change in a gene pool • G.H. Hardy (English Mathematician) & W. Weinberg (German Physician) recognized the potential constancy, or equilibrium state, of gene pool frequencies • Used a binomial expression to calculate the genotypic and allele frequencies of a population • Hardy-Weinberg Equation: p2 + 2pq + q2 • p2 = % homozygous dominant individuals (AA) • p = frequency of dominant alleles • q2 = % homozygous recessive individuals • q = frequency of recessive allele • 2 pq = % heterozygous individuals p+q=1 (Sum of frequencies in both alleles is 100%) p2+2pq+q2=1 • H.W Law states that equilibrium of allele frequencies in a gene pool, will remain in effect in each succeeding generation of a sexually reproducing population as long as 5 conditions are met • 5 conditions: 1. No Mutations: allelic changes do not occur, or changes in one direction are balanced by the changes in the opposite direction 2. No Gene Flow: migration of alleles into or out of the population does not occur 3. Random Mating: individuals pair by chance and NOT according to their genotypes and phenotypes 4. No Genetic Drift: the population is very large , and changes in allele frequencies due to chance alone are insignificant 5. No Selection: no selective agent favors one genotype over another Why is H-W Law Important? • Provides a baseline by which we can judge if evolution has occurred • In life, the 5 conditions for maintaining equilibrium of allele frequencies, are rarely met if ever; hence the fact we have genetic variation • Any change of allele frequencies in the gene pool of a population signifies evolution has occurred Calculating Gene Pool Frequencies using H-W • 16% of the human population has a continuous hairline (recessive trait). Using this information complete all the allele and genotypic frequencies for the population. Assuming H-W equilibrium conditions are met. Where do we start? SOLVE! • What percentage of the population will have the dominant phenotype? Recessive? H-W Lab: Case #2 • Recall the five requirements of H-W equilibrium 1. For your row (Labels for each row are placed at the front), describe how you will modify that H-W requirement, so that it no longer applies to your experiment 2. Next, draw out another data just as you did yesterday; label this graph as “Out of Equilibrium” 3. Take your pre-sorted cup of alleles, decide which color will be dominant and which will be recessive 4. Record the number you have of each allele (ex. 25 - B, 35 - b) 5. Using the H-W equation, do the % of dominant alleles and recessive alleles in the population (ex. 25/100 = 25%) 6. Apply the modification you came up with to your population (ex. Having no random mating, you would specifically pick out the genotypes you want) 7. Perform 5 generations, as you did yesterday, record your data 8. Compare the results you got in your group to another groups results. Similarities? Major differences? 9. Answer the questions for each Case Study (#1 and #2). 10. Turn in your data tables, graphs and answers to your questions. 11. Once you finish with the lab, you can work on the H-W Practice Problems I gave you for HW this week and the Post-Learning portions for your journals!