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Lecture 2. Working Principles of Microsystems 2.1 Microsensors Definition of Sensor: A sensor is a device that converts one form of energy into another and provides the user with a usable output in response to a specific measurable input. 2.1.1 Acoustic Wave Sensors Principal application: - To detect chemical components in a gas. Basic idea: - To fabricate a sensor in which acoustic waves are propagated, and where some aspect of that propagation (e.g., velocity, amplitude, etc.) is changed by - the adsorption/reaction or viscosity of the sensed species. (Kovacs, 2000) Generation of acoustic waves: piezoelectric (the most popular), magnetostrictive, etc. 2.1.2 Biomedical Sensors and Biosensors BioMEMS encompasses: 1. 2. 3. Biosensors; Bioinstruments and surgery tools; Biotesting and analytical systems Biomedical Sensors: To detect biological substance. Example: one for glucose (血糖) concentration - Glucose + O2 → gluconolactone + H2O2 - Then, H2O2 → O2 + 2H+ + 2e- By measuring the current or the pH, the glucose concentration can be determined. 1 表一 二十位糖尿病專家對糖尿病診斷之分歧標準 (http://www.ilshb.gov.tw/dm/) 血糖 mg/dl 正常人最高限 糖尿病人最低限 空腹血糖 105-120 120-160 1 小時血糖 160-209 185-250 2 小時血糖 120-250 105-180 Biosensors Definition: Any measuring devices that contain a biological element. The biomolecules (such as enzymes, antibodies, etc.), when attached to the sensing elements, can alter the output signals of the sensors. Schematic of biosensors: 2 Biotesting and Analytical Systems These systems separate various species in biological samples. Electrohydrodynamics involves the driving of an ionized fluid by the application of electric fields. 2.1.3 Chemical Sensors Used to sense particular chemical components, such as various gas species. 4 types: I. Chemiresistor sensors - Chemiresistros are simply structures in which the resistance (or impedance) between two electrical contacts is modified depending on the quantity of an unknown in the environment. (Kovacs, 2000) 3 - Example: A polymer called phthalocyanine is used with copper to sense NH3 and NO2. II. Chemicapacitor sensors: - Some polymers can be used as dielectric materials in a capacitor. - Exposed to certain gases → its dielectric constant changes → capacitance changes III. Chemimechanical sensors - Certain materials (e.g., polymers) would change shape when exposed to - chemicals including moisture. One may detect such chemicals by measuring its dimension change. Example: A moisture sensor using pyraline PI-2722. IV. Metal xodie gas sensors - The working principle is similar to that of chemiresistor sensors. - Several semiconducting metals, such as SnO2, change their electric resistance after absorbing certain gases. 4 Catalyst deposition can speed up the reaction and hence increase the sensitivity of the sensor. 2.1.4 Optical Sensors Figure 2.6(a): The photovoltaic junction can produce an electric potential when the more transparent substrate of semiconductor A is subjected to incident photon energy. Figure 2.6(b): A special material changes its electric resistance when exposed to light. Incident photon energy can be converted into electric current output from these devices. 5 2.1.5 Pressure Sensors Principle: - Mechanically induced diaphragm deformation and stresses are then 6 converted into electrical signal output through several means of transduction. Two types: absolute and gage pressure sensors - Absolute: has an evacuated cavity on one side of the diaphragm so that the measured pressure is the absolute value with vacuum as the reference. - Gage: no evacuation is necessary. Back-side and front-side pressurization (Fig. 2.7): - Back side: no interference with signal transducer. - Front side: used under special circumstances because of interference of pressurizing medium with the signal transducer In Fig. 2.8, four piezoresistors implanted beneath the silicon die, and a Wheatstone bridge circuit is used. - By an applied pressure, the values of R1 and R3 increase, whereas those of R2 and R4 decrease. - The output voltage from the Wheatstone bridge is: R1 R2 Vo Vin R1 R4 R2 R3 - [eq. 2.1] Advantages: high gains and good linearity. Disadvantage: temperature sensitive. 7 R2 (-v) R3 (+v) Capacitive type (Fig. 2.9): - Principle: Any deformation of the diaphragm due to the applied pressure will narrow the gap between two electrodes, leading to a change of capacitance across the electrodes. - Capacitance: C r 0 A d [Eq. 2.2] where εr: relative permittivity, ε0: permittivity of vacuum, d: gap, and A: area. - Output Voltage: 8 Vo - C Vin 2(2C C ) Advantages: independent of the operating temperature. 9 [eq. 2.3] - Disadvantages: Not as sensitive as those with piezoresistors. The relation between the output and the capacitance change is nonlinear. Vibrating-beam type (Fig. 2.12): - has a n-type silicon beam and p-type electrode. - The beam is made to vibrate at its resonant frequency by applying an ac signal to the electrode before the application of pressure. - The stress induced in the diaphragm (and the die) will be transmitted to the - vibrating beam, causing a shift of natural frequency. The shift of natural frequency can be correlated to the applied pressure. Advantage: (1) insensitive to temperature; and (2) good linearity. - Disadvantage: costly on fabrication. 2.1.6 Thermal Sensors Thermocouples: - A voltage is produced at the open ends of two dissimilar metallic wires when the junction of the wires is heated (Fig. 2.13a). - Seebeck effect: A thermocouple is arranged with both hot and cold junctions (Fig. 2.13b), and the following voltage is generated: V=βΔT where β is the Seebeck coefficient, and ΔT is the temperature 10 difference between hot and cold junctions. Microthermopile: - Thermopiles operate with both hot and cold junctions, but they are arranged with thermocouples in parallel and voltage output in series (Fig. 2.14). V=NβΔT where N is the number of thermocouple pairs. 11 In Fig. 2.15, a total of 32 polysilicon-gold thermocouples were used in the thermopile. - The chip dimension: 3.6mm X 3.6mm X 20μm - A typical output signal of 100 mV was obtained from a 500 K blackbody radiation source of Q=0.29 mW/cm2. 2.2 Microactuation Four commonly used means for microdevice actuation are: (1) thermal forces; (2) shape memory alloys; (3) piezoelectric crystals; (4) electrostatic forces. 2.2.1 Actuation Using Thermal Forces Principles: Bimetallic strips are made by binding two materials with distinct thermal expansion coefficients (also called thermal bimorph actuator). The strip will bend when heated or cooled from the initial reference temperature (Fig. 2.16). Examples: microclamps or valves. 12 2.2.2 Actuation Using Shape Memory Alloys Principles: - The shape memory alloys (SMA) tend to return to their original shape at a preset temperature. - Example in Fig. 2.17, A SMA strip is in a bent shape at a designed preset temperature T. The silicon beam is set straight at the room temperature. Heating the SMA to temperature T would prompt the SMA strip to return to its original bent shape, causing the beam to deform with the strip. 2.2.3 Actuation Using Piezoelectric Crystals Principles: - Certain crystals deform with the application of an electric voltage. - The reverse is also valid. Deforming the crystal would generate a voltage. 13 - Example: 2.2.4 Actuation Using Electrostatic Forces Coulomb’s Law: Two charge particles with charges q and q’ would exert an electrostatic force to each other: 1 qq' 4 r 2 where ε: permittivity of the material. F 14 [Eq. 2.5] Electrostatic Force in Parallel Plates - In Fig. 2.21, the induced capacitance between the plates is C r 0 A WL r 0 d d [Eq. 2.6] - The energy associated with the electric potential can be expressed as: - WLV 2 1 U CV 2 r 0 2 2d The associated force that is normal to the plates is - U 1 r 0WLV 2 Fd d 2 d2 The associated forces in the W and L directions are - [Eq. 2.7] [Eq. 2.8] FW U 1 r 0 LV 2 W 2 d [Eq. 2.10] FL U 1 r 0WV 2 L 2 d [Eq. 2.11] Drawback: The force magnitude is low. 15 2.3 MEMS with Microactuators 2.3.1 Microgrippers Principle: The required gripping forces in a gripper can be provided either by normal force (Fig. 2.24a) or by the in-plane forces from pairs of misaligned plates (Fig. 2.24b). 16 Disadvantage of the design in Fig. 2.24a: The electrodes occupy excessive space. Comb drives as Fig. 2.24b or: 2.3.2 Micromotors Two types: linear and rotary motors - Linear motors: Energizing the pair of electrodes A and A’ causes the top plate to move to the left until they are fully aligned. Then, energize the pairs of electrodes B and B’, C and C’, and D and D’ in sequence. 17 - Rotary motors: 2.3.3 Microvalves Applications: - Precision control of gas flow for manufacturing processes; Biomedical systems such as in controlling the blood flow in an artery (動脈). The microvalve in Fig. 2.29 (Jerman, 1991) uses the thermal bimorph actuation (like the one in Fig. 2.16). - Heating the two electrical resistor rings can cause a downward movement of the diaphragm to close the flow passage. 18 Figure 2.30, - The downward bending of the silicon diaphragm (to close the valve) is activated by heat supplied to a special liquid in the sealed compartment (隔間) above the diaphragm. 2.3.4 Micropumps Figure 2.31, - Use the electrostatic actuation to deform the diaphragm. - Apply a voltage across the electrodes Diaphragm: deform upward Chamber volume: increase 19 Chamber pressure: reduce Inlet check valve: open (fluid flows in) Then, cut off the applied voltage Diaphragm: return to its initial position Chamber volume: reduce Chamber pressure: increase outlet check valve: open (fluid flows out) - Zengerle (1992) reported Diaphragm size: 4mm×4mm×25μm thick Gap between the diaphragm and electrode: 4μm Actuation frequency: 1 to 100 Hz Pumping rate: 70μL/min at 25 Hz 2.4 Microaccelerometers Functions: - measure accelerometer; - measure the applied force by F=ma. Applications: - ±2g range for the car’s suspension system and antilock braking system. 20 - ±50g range for the actuation of air bags. Principal components of an accelerometer (Fig. 2.32): Figure 2.33 shows a microaccelerometer: - Silicon beam: serve as a spring. - Mass M: also called a seismic mass or proof mass. - Air in the surrounding: produce damping. - Piezoresistor: measure the deformation correlated to the acceleration (Details: discussed in Chapter 4.) Figure 2.34: use differential capacitance - Components: a proof mass (thin beam), two springs (tethers [拴繩,拴鏈] 21 made of elastic material), and a differential capacitive sensing. - Principles: In the event of acceleration, the proof mass will displace in the direction opposite to the acceleration. (??) The differential capacitive sensor cell senses the movement. Figure 2.36: dual-axial-motion sensor. 22 2.5 Microfluidics Applications: - Chemical analysis - Biological and chemical sensing - Drug delivery - Molecular separation such as DNA analysis - Amplification, sequencing or synthesis of nucleic acids - Environmental monitoring Principal advantages: - Small samples Better performance with reduced power consumption Can be combined with traditional electronic systems for a lab-on-a-chip - (LOC) Produced in batches s.t. disposable (可丟棄的) Major components of a microfluidic system: 1. Microsensors: used to measure fluid properties (pressure, temperature, and flow rate, etc.). 2. 3. 4. Actuators: used to alter the state of fluids (microvalves, micropumps, and compressors, etc.). Distribution channels: regulate flows in various branches in the system (capillary networks in Fig. 2.3, microchannels in Fig. 2.37, etc). System integration: integrate 1, 2, 3, and electrical systems that provides electrohydrodynamic (電之流體動力學) forces, the circuits for transducing and processing the electronic signals, and control of the microfluid flow in the system. 23 24