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Transcript
I.
Essential Knowledge 3.C.3: Viral replication results in genetic
variation and viral infection can introduce genetic variation into the
hosts.
A.
Viral replication differs from other reproductive strategies and
generates genetic variation via various mechanisms.
B.
The reproductive cycles of viruses facilitate transfer of genetic
information.
1.
Explain the basic structure of a virus.
2.
Viruses reproduce in a host cell following one of two general
replicative mechanisms. Compare and contrast the lytic cycle and lysogenic
cycle of viral reproduction.
3.
Explain the replicative cycle of a retrovirus, like HIV.
4.
How are plasmids and transposons similar to a virus? How does this
characteristic affect a viral genome?
5.
Outline the the three processes that contribute to the emergence of
viral diseases.
C.
General comments about viral replication…
1.
Viruses have highly efficient replicative capabilities that allow for
rapid evolution and acquisition of phenotypes.
2.
Viruses replicate via a component assembly model allowing one virus
to produce many progeny simultaneously via the lytic cycle.
3.
Virus replication allows for mutations to occur through usual host
pathways.
4.
RNA viruses lack replication error-checking mechanisms, and thus
have higher rates of mutation.
5.
Related viruses can combine/recombine information if they infect the
same host cell.
6.
HIV is a well-studied system where the rapid evolution of a virus within
the host contributes to the pathogenicity of viral infection.
7.
Viruses transmit DNA and RNA when they infect a host cell.
8.
Some viruses are able to integrate into the host DNA and establish a
latent (lysogenic) infection. These latent viral genomes came result in
properties for the host such as increased pathogenicity in bacteria.