Download Research Fast Facts: BRCA

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts

Public health genomics wikipedia , lookup

Nutriepigenomics wikipedia , lookup

RNA-Seq wikipedia , lookup

Microevolution wikipedia , lookup

Epistasis wikipedia , lookup

Cancer epigenetics wikipedia , lookup

Genome (book) wikipedia , lookup

Frameshift mutation wikipedia , lookup

Mutagen wikipedia , lookup

Mutation wikipedia , lookup

NEDD9 wikipedia , lookup

Point mutation wikipedia , lookup

Oncogenomics wikipedia , lookup

BRCA mutation wikipedia , lookup

Transcript
Research Fast Facts: BRCA
BRCA Research Saves Lives
What We’re Investigating
BRCA1 and BRCA2 (breast cancer susceptibility)
are genes that help prevent cancer from developing. They repair cell damage so breast cells can
grow normally. Everyone has BRCA genes. But,
when BRCA is mutated, it cannot function
normally and breast cancer risk increases.
Most inherited breast cancers are a result of BRCA
mutations and people who have them are at
increased risk; however, not all people with the
BRCA mutation will get breast cancer. Nonetheless, making decisions to manage this risk can be
overwhelming. Komen has long been committed
to finding newer and better ways of detecting,
treating, and preventing cancer in BRCA mutation
carriers.
Komen-funded researchers are:
 Developing new ways to prevent breast
cancer in BRCA mutations carriers, including new drugs, hormone therapies, and
dietary approaches
 Identifying environmental or hormonal
factors that may contribute to breast
cancer risk in women with the BRCA
mutation
 Understanding how BRCA mutations lead
to breast cancer so that targets for new
drugs can be identified
 Determining whether certain BRCA muta-
tions are associated with more aggressive
breast cancers and occur more frequently
in select populations
Total Investment In BRCA Research
Treatment
12%
Survivorship
6%
Biology
32%
What We’ve Learned
Komen-funded research has helped us to
understand that:
Prevention
17%
 Mutations in the BRCA1 gene are associated
with familial breast cancer
Model Systems
3%
Early Detection
6%
Etiology
24%
Susan G. Komen has invested more than $34 million in
over 100 grants focused on BRCA related research.
 Women from the Bahamas appear to be
twice as likely to have a BRCA1 mutation than
the general population
 Newly identified genetic risk factors may help
predict which women with the BRCA mutation will get cancer
More Than Research
These research investments reflect only part of our
commitment to supporting those with BRCA mutations.
Komen also provides educational materials and conference support to help BRCA carriers understand their risks
and receive up to date information on current treatments
and research.
Breast cancer survivor Terri Swain shares her experience
and thoughts on genetic testing for BRCA mutations.
Survivors at the 2012 Bahamanaian Race for the Cure
The Susan G. Komen for the Cure® promise is to save lives and end breast cancer forever.
Learn more at www.komen.org. ©2012 Susan G. Komen for the Cure® The Running Ribbon is a registered trademark of Susan G. Komen for the Cure®.