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Peter Parham
The Immune System
Second Edition
Chapter 3
Antigen Recognition
by T Lymphocytes
Copyright © 2005 by Garland Science Publishing
Figure 3-1 part 1 of 2
Figure 3-1 part 2 of 2
Figure 3-2
Figure 3-3
Severe combined immunodeficiency disease (SCID)
rare-one or more recombination genes defective (RAG)
Figure 3-4
Candida albicans
Omenn syndrome - RAG proteins have partial activity –
rapidly fatal
Figure 3-5
T cell receptor complex
8-polypeptides
a alpha
b beta
g gamma
d delta
e epsilon
z zeta
Figure 3-6
Figure 3-7
1-5% T cells in circulation, >50% in epithelial tissue
Not MHC restricted
Can bind/respond to non-protein antigens
Figure 3-8
Figure 3-9
Helper T cells
Figure 3-10
Cytotoxic T cells
Figure 3-11
Figure 3-12
response – lyse target
response – release cytokines
activate B cell
Figure 3-13 part 1 of 2
Figure 3-13 part 2 of 2
Figure 3-14
Figure 3-15
Two compartments
1. Cytosol/nucleus
2. Vesicular system
Figure 3-16
Proteasome- degradation of
“old” proteins
Figure 3-17
Transporter of antigenic
peptides
Figure 3-18
Figure 3-19
Figure 3-20
Figure 3-21
Figure 3-22 part 1 of 2
*activated only
Figure 3-22 part 2 of 2
microglia cells are +
Human MHC – Human leukocyte antigen complex
HLA-A,B,C
-present peptide Abs used to ID MHC molecules react with leukocytes not RBCs
antigens to CD8
Tcells and interact
with NK-cells
Figure 3-23
HLA-E,G
-interact
with NK-cells
HLA-F
-?
HLA-DP,DQ,DR
- present peptide
antigens to CD4
Tcells
HLA-DM,DO
-regulate peptide
loading of
DP,DQ,DR
Figure 3-24 part 1 of 2
proteins
Figure 3-24 part 2 of 2
Figure 3-25
Figure 3-26
Figure 3-27
Figure 3-28 part 1 of 2
Figure 3-28 part 2 of 2
Figure 3-29
L-lysine
Y-tyrosine
V- valine
R-arginine
W-tryptophane
Figure 3-30
Co-
Figure 3-31
Large circles- total # antigenic
peptides that can be presented
via MHCI & MHCII
small circles- total # antigenic
peptides that can be presented
via an individual
MHCI & MHCII haplotype
Week 1
Week 2
Week 3
Week 4
Week 5
Week 6
Aug 23
Introduction
Aug 25
Chapter 1
Aug 30
Chapter 1
Sept 1
Chapter 2
Sept 6
Labor Day
Sept 8
Chapter 2
Sept 13
Chapter 3
Sept 15
Chapter 3
Sept 20
Chapter 4
Sept 22
Review
Sept 27
Exam 1
Sept 29
Chapter 4
Advantages for heterozygous for the MHC
Figure 3-32 part 1 of 2
Figure 3-32 part 2 of 2
Recombination between
alleles of the same
gene
Figure 3-33 part 1 of 2
Generation of new
MHC alleles
DP,DQ,DR
HLA B*5301Found in African
populations and
associated with
resistance to
severe malaria
Figure 3-33 part 2 of 2
Recombination between
alleles of the different
gene
Generation of new
MHC alleles
HLA B*4601- Found in southeast Asian populations and
associated with susceptibility to nasopharyngeal carcinoma.
Figure 3-34
Red – heterozygous for all the highly polymorphic HLA I and II
Yellow - Homozygous for one locus
Blue - Homozygous for two or three loci