Download Terrovitis I Short CV

Ioannis Terrovitis, Short CV
NAME
Terrovitis, Ioannis
ADDRESS
20 Pentelis str, 15343, Athens, Greece
CURRENT POSITION
Assistant Professor, University of Athens, Greece
Tel: +30-210-6083280 (home),
+30-210-8236877 (work)
email: [email protected]
[email protected]
EDUCATION/TRAINING
INSTITUTION AND LOCATION
National University of Athens, School of
Medicine, Athens, Greece
National University of Athens, School of Medicine
DEGREE
YEAR(s)
FIELD OF STUDY
MD
1993
Medicine
Doctoral
Thesis
2002
Medicine-cardiology
Positions
1997-1999
1999-2003
2004-2005
2005-2008
2008-2009
01/200905/2009
05/2009present
Resident in Internal Medicine, ‘Patission Hospital’, Athens, Greece
Fellow in Cardiology, University of Athens, Dept. of Clinical Therapeutics,
‘Alexandra’ Hospital, Athens
Academic Visitor, Imperial College, London-Supervisor: Prof. Sir Magdi H. Yacoub
Postdoctoral research fellow, Johns Hopkins University-Supervisor: Prof. Eduardo
Marbán
Postdoctoral research fellow, Cedars Sinai Medical Center-Supervisor: Prof.
Eduardo Marbán
Lecturer, University of Athens, Greece
Assistant Professor, University of Athens, Greece, School of Medicine, 3rd
Department of Cardiology (Outpatient Heart Failure Clinic, LVAD program, head of
the Basic Research Laboratory of the Department)
Licenses and certification
1994
1995
2003
2005
2008
Greek Medical Board License
ECFMG Certification
Greek Board of Cardiology
Certificate of Training in Cardiovascular Magnetic Resonance (level II Accreditation
according to the Society of Cardiovascular Magnetic Resonance)
Certificate of Training in CT Angiography
Professional Membership
1994
2005
2005
2006
2006
2007
2010-present
Member, Hellenic Medical Association
Hellenic Cardiologic Society
European Society of Cardiology
American Heart Association
AHA Council of Basic Cardiovascular Research
Hellenic Heart Failure Society
President of the Working Group of Basic and Translational Research of the Hellenic
Cardiologic Society (for the term of 2012-2104)
Scholarships
2004-2005
2005-2008
Scholarship from the Hellenic Cardiologic Society for Basic Research in Cardiology
Scholarship from the National Foundation of Scholarships for Basic Reearch in
Cardiology
Honors/Awards
1987-1991
2007
2008
2008
Awards from the Greek National Scholarship Foundation, for excellent performance
during medical studies
Melvin Judkins Young Investigator Award in Cardiovascular Radiology, American
Heart Association Scientific Sessions
Stanley L. Blumenthal, M.D. Cardiology Research Awards, Johns Hopkins
University
American Heart Association Scientific Sessions- Melvin Judkins
Young Investigator Award, Finalist, AHA Council of Cardiovascular
Imaging
International invited lectures
2008
2009
2011
2011
American Heart Association Scientific Sessions -Moderator of the session: Basic Research
in Nuclear Medicine , November 2008
Multimodality imaging for studying cardiac stem cell engraftment (from mouse to man)University La Sapienza, October 2009
Molecular imaging approaches to assess stem cell effects in vivo: best guide to determine
cell dose, type, and mode of administration - Heart Failure Association (European Society
of Cardiology) Cardiac Stem Cell Workshop-Brussels May 2011
Heart-derived cells for post-MI ventricular dysfunction – 8th International Symposium on
Stem Cell Therapies- Madrid, June 2011
ii) Research achievements
2002
Completion of doctoral thesis. This project involved the use of an innovative Left
Ventricular Assist Device (Paraaortic Counterpulsation Pump) during cardiogenic
shock, in a large animal (pig) experimental model. At the same time, I started
experimental research protocols in the University of Athens using bone marrow
derived stem cells for amelioration of ventricular remodeling.
2004-2005
Research and training in stem cells and tissue engineering, in Imperial College
London. I was involved in the development of a tissue engineered cardiac valve
using biomaterial scaffolds and mesenchymal stem cells.
2005-2009
Basic and translational research using cardiosphere-derived stem cells for
myocardial regeneration in Johns Hopkins University and Cedars Sinai Medical
Center.
I was involved in the development of imaging methods, both for small and large
animal models, aiming at cell tracking after delivery in the heart. Our purpose was
to investigate the efficiency of the delivery methods and study short term cell
retention and long term engraftment. With the help and support of scientists from
basic research disciplines such as molecular biology and physics, I applied every
available modality (bioluminescence imaging, Single Photon Emission Tomography
and Positron Emission Tomography, Magnetic Resonance Imaging) in our research
and defined the exact retention and survival rates of CDCs in the myocardium. I
developed protocols for direct radiolabeling of CDCs that allowed cell tracking using
the relevant modalities. In addition, we used reporter gene technology for
bioluminescence, SPECT and PET imaging. We were the first to provide compelling
evidence that a human gene (sodium-iodide-symporter) can be used as a reporter
gene for tracking genetically labeled cells by SPECT and PET imaging (Young
Investigator Award in the 2007 American Heart Association Sessions). This is an
important development considering the clinical translatability of this method. Using
the same modalities, we were able to apply simple techniques to improve cell
retention and in parallel the functional benefit of CDC therapy. These studies were
financed by NIH grants, as well as by other distinguished funding agencies
(Reynolds foundation and WW Smith foundation).
2009-present
I returned to Greece with an appointment in the University of Athens, School of
Medicine, in 2009. I established a new, basic research laboratory, as an addition
to the pre-existing laboratory for experimental research in large animals, in the 3rd
Department of Cardiology. The new laboratory has tissue culture, molecular biology
and small animal surgery capabilities. Currently, three MDs with experience in basic
research are performing experiments in this lab. In addition, three medical
graduates are conducting research in this lab, as a part of their doctoral thesis (with
myself as the supervisor). Several experimental studies involving the use of
cardiosphere-derived stem cells (both autologous and allogeneic) are being
conducted, currently in this lab.
In addition, I designed a randomized clinical study using peripheral blood
mononuclear cells (after stimulation with growth factors) for prevention of left
ventricular remodeling, in patients with large anterior myocardial infarcts. The trial
was conducted in the Dept. of Therapeutics of the University of Athens and
preliminary results were presented in American Heart Association Scientific
Sessions (oral presentation-November 2011, Orlando, USA). Final results are
available and a manuscript is under preparation.
At the same time I continued my collaboration with Cedars Sinai Medical Center.
Among other projects, I was the primary author of the protocol for a clinical trial
(ALLSTAR- NCT01458405), where allogeneic cardiosphere-derived stem cells will
be administered to patients, by intracoronary delivery, in the setting of chronic MI
(1month to 1 year post MI). This trial has recently started enrolling patients.
Additional research projects
2009-present Reverse left ventricular remodeling by prolonged mechanical support of the
circulation using a novel counterpulsation pump
PI: Prof John Nanas
2010-present Pathophysiologic mechanisms of anemia in patients with heart failure
PI: Prof John Nanas
2010-present Ultrafiltration for the management of patients with advanced heart failure
PI: Prof John Nanas
2010-present Pathophysiologic mechanisms of osteoporosis in patients with heart failure
PI: Ass. Prof John Terrovitis
2010-present Amelioration of reperfusion injury by stabilization of mitochondrial inner membrane,
using 4-chlorodiazepam
PI: Ass. Prof John Terrovitis
2012-present Investigation of the potentially detrimental role of high diuretic doses on left
ventricular remodeling, in a small animal model of chronic myocardial infarction
PI: Ass. Prof John Terrovitis
iii) Grants
1999
Grant from the General Secretariat for Research and Technology for research in
cardiogenic shock (Comparison of the performance of two counterpulsation devicesNo. 25303/9.7.99-PI: Prof. J. Nanas). The experiments were completed successfully
and the results were the main topic of my doctoral thesis.
2005
Supported by funds of the LeDuc Fondation, as a co-investigator in cardiac stem cell
research (PI: Prof. Eduardo Marbán).
2005-2008
Supported by funds of the SCCT (Specialized Centers for Cell-Based Therapy)
National Heart Lung and Blood Institute (NIH) grant (RFA-HL-04-017) as a coinvestigator in cardiac stem cell research (PI: Prof Eduardo Marbán).
2005-2008
Supported by a grant of the Donald Reynolds foundation as a co-investigator in
cardiac stem cell research (PI: Prof. Eduardo Marbán)
2008
Supported by the WW Smith foundation (Multimodality Stem Cell Imaging-PI: Assist.
Professor MR Abraham)
iv) Peer-reviewed publications
1: Agapitou V, Dimopoulos S, Kapelios C, Karatzanos E, Manetos C, Georgantas A, Ntalianis A, Terrovitis J,
Karga H, Nanas S. Hormonal imbalance in relation to exercise intolerance and ventilatory inefficiency in chronic
heart failure. J Heart Lung Transplant. 2013 : S1053-2498(12)01480-5.
2: Terrovitis JV, Kapelios CJ, Sainis G, Ntalianis A, Kaldara E, Sousonis V, Vakrou S, Michelinakis N,
Anagnostou D, Margari Z, Nanas JN. Elevated left ventricular filling pressures can be estimated with accuracy
by a new mathematical model. J Heart Lung Transplant. 2013 : S1053-2498(13)01023-1.
3: Karvounis EC, Tsipouras MG, Tzallas AT, Goletsis Y, Fotiadis DI, Terrovitis J, Trivella MG. Knowledge
editor and execution engine development for optimal ventricular assist device weaning. Conf Proc IEEE Eng
Med Biol Soc. 2012 ;:1262-5.
4: Tseliou E, Pollan S, Malliaras K, Terrovitis J, Sun B, Galang G, Marbán L, Luthringer D, Marbán E.
Allogeneic Cardiospheres Safely Boost Cardiac Function and Attenuate Adverse Remodeling After Myocardial
Infarction in Immunologically Mismatched Rat Strains. J Am Coll Cardiol. 2013: S0735-1097(12)05980-3.
5: Chang C, Chan A, Lin X, Higuchi T, Terrovitis J, Afzal JM, Rittenbach A, Sun D, Vakrou S, Woldemichael
K, O'Rourke B, Wahl R, Pomper M, Tsui B, Abraham MR. Cellular bioenergetics is an important determinant of
the molecular imaging signal derived from luciferase and the sodium-iodide symporter. Circ Res. 2013
;112(3):441-50.
6: Barth AS, Zhang Y, Li T, Smith RR, Chimenti I, Terrovitis I, Davis DR, Kizana E, Ho AS, O'Rourke B,
Wolff AC, Gerstenblith G, Marbán E. Functional impairment of human resident cardiac stem cells by the
cardiotoxic antineoplastic agent trastuzumab. Stem Cells Transl Med. 2012 ;1(4):289-97.
7: Terrovitis JV, Kaldara E, Ntalianis A, Sventzouri S, Kapelios C, Barbarousi D, Matsouka C, Nanas JN.
Intravenous iron alone is equally effective with the combination of iron and erythropoietin for the treatment of
iron-deficiencyanemia in advanced heart failure. J Am Coll Cardiol. 2012 ;60(21):2255-6.
8: Pierrakos CN, Tsolakis EJ, Pozios IA, Diakos N, Charitos E, Malliaras K, Bonios MJ, Lazaris N, Papazoglou
P, Venetsanakos J, Papalois A, Terrovitis JV, Nanas JN. Effects of l-NAME on coronary blood flow, infarct size
and the extentof the no-reflow phenomenon. Int J Cardiol. 2012 : S0167-5273(12)01101-1.
9: Drakos SG, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Terrovitis JV, Nanas JN, Li DY. Bridge to
recovery: understanding the disconnect between clinical and biological outcomes. Circulation. 2012;126(2):23041.
10: Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka
H, Marbán L, Marbán E. Direct comparison of different stem cell types and subpopulations reveals superior
paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll
Cardiol. 2012 ;59(10):942-53.
11: Terrovitis J, Zotos P, Kaldara E, Diakos N, Tseliou E, Vakrou S, Kapelios C, Chalazonitis A, Nanas S,
Toumanidis S, Kontoyannis D, Karga E, Nanas J. Bone mass loss in chronic heart failure is associated with
secondary hyperparathyroidism and has prognostic significance. Eur J Heart Fail. 2012 Mar;14(3):326-32.
12: Wever-Pinzon O, Stehlik J, Kfoury AG, Terrovitis JV, Diakos NA, Charitos C, Li DY, Drakos SG.
Ventricular assist devices: pharmacological aspects of a mechanical therapy. Pharmacol Ther. 2012
May;134(2):189-99.
13: Mavrogeni S, Bratis K, Terrovitis J, Tsagalou E, Nanas J. Fulminant myocarditis. Can cardiac magnetic
resonance predict evolution to heart failure? Int J Cardiol. 2012 Aug 23;159(2):e37-8.
14: Malliaras K, Li TS, Luthringer D, Terrovitis J, Cheng K, Chakravarty T, Galang G, Zhang Y, Schoenhoff F,
Van Eyk J, Marbán L, Marbán E. Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted
with mismatched cardiosphere-derived cells. Circulation. 2012 ;125(1):100-12.
15: Manetos C, Dimopoulos S, Tzanis G, Vakrou S, Tasoulis A, Kapelios C, Agapitou V, Ntalianis A, Terrovitis
J, Nanas S. Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory
inefficiency, and impaired autonomic control in heart failure. J Heart Lung Transplant. 2011 ;30(12):1403-8.
16: Dimopoulos S, Diakos N, Tseliou E, Tasoulis A, Mpouchla A, Manetos C, Katsaros L, Drakos S, Terrovitis
J, Nanas S. Chronotropic incompetence and abnormal heart rate recovery early after left ventricular assist device
implantation. Pacing Clin Electrophysiol. 2011;34(12):1607-14.
17: Bonios MJ, Terrovitis JV, Kaldara E, Ntalianis A, Nanas JN. The challenge of treating congestion in
advanced heart failure. Expert Rev Cardiovasc Ther. 2011 ;9(9):1181-91.
18: Pierrakos CN, Bonios MJ, Drakos SG, Charitos EI, Tsolakis EJ, Ntalianis A, Nanas SN, Charitos CE, Nanas
JN, Terrovitis JV. Mechanical assistance by intra-aortic balloon pump counterpulsation during reperfusion
increases coronary blood flow and mitigates the no-reflow phenomenon: an experimental study. Artif Organs.
2011 ;35(9):867-74.
19: Lautamäki R, Terrovitis J, Bonios M, Yu J, Tsui BM, Abraham MR, Bengel FM. Perfusion defect size
predicts engraftment but not early retention of intra-myocardially injected cardiosphere-derived cells after acute
myocardial infarction. Basic Res Cardiol. 2011 ;106(6):1379-86.
20: Bonios M, Chang CY, Terrovitis J, Pinheiro A, Barth A, Dong P, Santaularia M, Foster DB, Raman V,
Abraham TP, Abraham MR. Constitutive HIF-1α expression blunts the beneficial effects of cardiospherederived cell therapy in the heart by altering paracrine factor balance. J Cardiovasc Transl Res. 2011 ;4(3):36372.
21: Bonios M, Chang CY, Pinheiro A, Dimaano VL, Higuchi T, Melexopoulou C, Bengel F, Terrovitis J,
Abraham TP, Abraham MR. Cardiac resynchronization by cardiosphere-derived stem cell transplantation in an
experimental model of myocardial infarction. J Am Soc Echocardiogr. 2011 ;24(7):808-14.
22: Bonios MJ, Terrovitis JV, Drakos SG, Katsaros F, Pantsios C, Nanas SN, Kanakakis J, Alexopoulos G,
Toumanidis S, Anastasiou-Nana M, Nanas JN. Comparison of three different regimens of intermittent inotrope
infusions for end stage heart failure. Int J Cardiol. 2012 ;159(3):225-9.
23: Bonios M, Terrovitis J, Chang CY, Engles JM, Higuchi T, Lautamäki R, Yu J, Fox J, Pomper M, Wahl RL,
Tsui BM, O'Rourke B, Bengel FM, Marbán E, Abraham MR. Myocardial substrate and route of administration
determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells. J Nucl Cardiol. 2011
;18(3):443-50.
24: Drakos SG, Terrovitis JV, Nanas JN, Charitos EI, Ntalianis AS, Malliaras KG, Diakos N, Koudoumas D,
Theodoropoulos S, Yacoub MH, Anastasiou-Nana MI. Reverse electrophysiologic remodeling after cardiac
mechanical unloading for end-stage nonischemic cardiomyopathy. Ann Thorac Surg. 2011 ;91(3):764-9.
25: Lee ST, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li TS, Terrovitis J, Yee K, Simsir S,
Makkar R, Marbán E. Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells
preserves function and minimizes adverse ventricular remodeling in pigs with heart failure
post-myocardial infarction. J Am Coll Cardiol. 2011 ;57(4):455-65.
26: Stavrakis S, Terrovitis J, Tsolakis E, Drakos S, Dalianis A, Bonios M, Koudoumas D, Malliaras K, Nanas J.
Relationship between retrograde coronary blood flow and the extent of no-reflow and infarct size in a porcine
ischemia-reperfusion model. J Cardiovasc Transl Res. 2011 ;4(1):99-105.
27: Agapitou V, Dimopoulos S, Mpouchla A, Samartzis L, Tseliou E, Kaldara E, Terrovitis J, Tasoulis A, Karga
E, Nanas S. Serum intact parathyroid hormone levels independently predict exercise capacity in stable heart
failure patients. Int J Cardiol. 2011 ;146(3):462-4
28: Kaldara-Papatheodorou EE, Terrovitis JV, Nanas JN. Anemia in heart failure: should we supplement iron in
patients with chronic heart failure? Pol Arch Med Wewn. 2010 ;120(9):354-60. Review.
29: Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Leiro MC, Drozdz J, Fruhwald F, Gullestad L,
Logeart D, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors A, Nielsen OW, Zannad F,
Tavazzi L; Heart Failure Association of ESC (HFA). EURObservational Research Programme: the Heart
Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010 Oct;12(10):1076-84 (co-PI in the appendix).
30: Bouchla A, Karatzanos E, Dimopoulos S, Tasoulis A, Agapitou V, Diakos N, Tseliou E, Terrovitis J, Nanas
S. The addition of strength training to aerobic interval training: effects on muscle strength and body composition
in CHF patients. J Cardiopulm Rehabil Prev. 2011 ;31(1):47-51.
31: Dimopoulos SK, Drakos SG, Terrovitis JV, Tzanis GS, Nanas SN. Improvement in respiratory muscle
dysfunction with continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2010 ;29(8):906-8.
32: Davis DR, Kizana E, Terrovitis J, Barth AS, Zhang Y, Smith RR, Miake J, Marbán E. Isolation and
expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol.
2010 Aug;49(2):312-21.
33: Terrovitis JV, Smith RR, Marbán E. Assessment and optimization of cell engraftment after transplantation
into the heart. Circ Res. 2010 ;106(3):479-94. Review.
34: Drakos SG, Athanasoulis T, Malliaras KG, Terrovitis JV, Diakos N, Koudoumas D, Ntalianis AS,
Theodoropoulos SP, Yacoub MH, Nanas JN. Myocardial sympathetic innervation and long-term left ventricular
mechanical unloading. JACC Cardiovasc Imaging. 2010 ;3(1):64-70.
35: Terrovitis J, Lautamäki R, Bonios M, Fox J, Engles JM, Yu J, Leppo MK, Pomper MG, Wahl RL, Seidel J,
Tsui BM, Bengel FM, Abraham MR, Marbán E. Noninvasive quantification and optimization of acute cell
retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J
Am Coll Cardiol. 2009 ;54(17):1619-26.
36: Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marbán E.
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One.
2009 ;4(9):e7195.
37: Tsagalou EP, Gounopoulos P, Terrovitis JV, Drakos SG, Katsaros FT, Kaldara EE, Alexopoulos GP,
Anastasiou-Nana MI. Amiodarone attenuates the proarrhythmic effects of dobutamine in patients with advanced
congestive heart failure. Hellenic J Cardiol. 2009 ;50(3):193-8.
38: Drakos SG, Bonios MJ, Anastasiou-Nana MI, Tsagalou EP, Terrovitis JV, Kaldara E, Maroulidis G, Nanas
SN, Kanakakis J, Nanas JN. Long-term survival and outcomes after hospitalization for acute myocardial
infarction complicated by cardiogenic shock. Clin Cardiol. 2009 ;32(8):E4-8.
39: Terrovitis JV, Anastasiou-Nana M, Kaldara E, Drakos SG, Nanas SN, Nanas JN. Anemia in heart failure:
pathophysiologic insights and treatment options. Future Cardiol. 2009 ;5(1):71-81.
40: Malliaras KG, Terrovitis JV, Drakos SG, Nanas JN. Reverse cardiac remodeling
enabled by mechanical unloading of the left ventricle. J Cardiovasc Transl Res.
2009 ;2(1):114-25. Review.
41: Ntalianis AS, Drakos SG, Charitos C, Dolou P, Pierrakos CN, Terrovitis JV, Papaioannou T, Charitos E,
Nanas JN. Effects of intra-aortic balloon pump versus centrifugal pump on myocardial energetics and systemic
circulation in a porcine model of rapidly worsening acute heart failure. ASAIO J. 2008
;54(6):600-5.
42: Terrovitis J, Kwok KF, Lautamäki R, Engles JM, Barth AS, Kizana E, Miake J, Leppo MK, Fox J, Seidel J,
Pomper M, Wahl RL, Tsui B, Bengel F, Marbán E, Abraham MR. Ectopic expression of the sodium-iodide
symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed
tomography or positron emission tomography. J Am Coll Cardiol. 2008 11;52(20):1652-60.
43: Tsagalou EP, Anastasiou-Nana M, Agapitos E, Gika A, Drakos SG, Terrovitis JV, Ntalianis A, Nanas JN.
Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart
failure due to idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2008 Oct 21;52(17):1391-8.
44: Drakos SG, Anastasiou-Nana MI, Terrovitis JV, Tsagalou EP, Kanakakis J, Ntalianis A, Lazaris N,
Maroulidis G, Venetsanakos J, Bonios M, Nanas JN. Intra-aortic balloon counterpulsation and delayed
revascularization for myocardial infarction and shock in the absence of primary angioplasty: a
treatment strategy with or without thrombolysis? Coron Artery Dis. 2008 ;19(7):521-6.
45: Bonios MJ, Pierrakos CN, Argiriou M, Dalianis A, Terrovitis JV, Dolou P, Drakos SG, Koudoumas D,
Charitos CE, Anastasiou-Nana MI. Increase in coronary blood flow by intra-aortic balloon counterpulsation in a
porcine model of myocardial reperfusion. Int J Cardiol. 2010 ;138(3):253-60.
46: Bonios MJ, Terrovitis JV, Abraham MR. Stem cell: "KANT" you see it? J Cardiovasc Transl Res. 2008
;1(2):103-5.
47: Barth AS, Kizana E, Smith RR, Terrovitis J, Dong P, Leppo MK, Zhang Y, Miake J, Olson EN, Schneider
JW, Abraham MR, Marbán E. Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report
cardiogenic differentiation in stem cells. Mol Ther. 2008 ;16(5):957-64.
48: Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Schär M, Gerstenblith G, Weiss RG,
Marbán E, Abraham MR. Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after
transplantation in the heart. Circulation. 2008 ;117(12):1555-62.
49: Drakos SG, Terrovitis JV, Anastasiou-Nana MI, Nanas JN. Reverse remodeling during long-term
mechanical unloading of the left ventricle. J Mol Cell Cardiol. 2007 ;43(3):231-42.
50: Terrovitis JV, Bulte JW, Sarvananthan S, Crowe LA, Sarathchandra P, Batten P, Sachlos E, Chester AH,
Czernuszka JT, Firmin DN, Taylor PM, Yacoub MH. Magnetic resonance imaging of ferumoxide-labeled
mesenchymal stem cells seeded on collagen scaffolds-relevance to tissue engineering. Tissue Eng. 2006
;12(10):2765-75.
51: Terrovitis JV, Anastasiou-Nana MI, Alexopoulos GP, Tsolakis EJ, Margari ZJ, Drakos SG, Tsagalou EP,
Papazoglou P, Efentakis S, Nanas JN. Prevalence and prognostic significance of anemia in patients with
congestive heart failure treated with standard vs high doses of enalapril. J Heart Lung Transplant. 2006
;25(3):333-8.
52: Nanas JN, Tsagalou EP, Nanas SN, Terrovitis JV, Tsolakis EJ, Toumanidis S, Papazoglou PD, Alexopoulos
GP, Kanakakis J, Anastasiou-Nana MI. Reverse left ventricular remodeling by intermittent dobutamine infusions
and amiodarone in end-stage heart failure due to idiopathic dilated cardiomyopathy. Int J Cardiol. 2006
;108(2):237-43.
53: Terrovitis JV, Anastasiou-Nana MI, Nanas JN. Out-patient management of chronic heart failure. Expert Opin
Pharmacother. 2005 ;6(11):1857-81. Review.
54: Anastasiou-Nana MI, Terrovitis JV, Athanasoulis T, Karaloizos L, Geramoutsos A, Pappa L, Tsagalou EP,
Efentakis S, Nanas JN. Prognostic value of iodine-123-metaiodobenzylguanidine myocardial uptake and heart
rate variability in chronic congestive heart failure secondary to ischemic or idiopathic dilated
cardiomyopathy. Am J Cardiol. 2005 ;96(3):427-31.
55: Tsagalou EP, Anastasiou-Nana MI, Terrovitis JV, Nanas SN, Alexopoulos GP, Kanakakis J, Nanas JN. The
long-term survival benefit conferred by intermittent dobutamine infusions and oral amiodarone is greater in
patients with idiopathic dilated cardiomyopathy than with ischemic heart disease. Int J Cardiol. 2006
;108(2):244-50.
56: Terrovitis JV, Kanakakis J, Nanas JN. Spontaneous coronary artery dissection as a cause of acute myocardial
infarction in the postpartum period. Cardiol Rev. 2005 ;13(4):211-3.
57: Nanas JN, Papazoglou P, Tsagalou EP, Ntalianis A, Tsolakis E, Terrovitis JV, Kanakakis J, Nanas SN,
Alexopoulos GP, Anastasiou-Nana MI. Efficacy and safety of intermittent, long-term, concomitant dobutamine
and levosimendan infusions in severe heart failure refractory to dobutamine alone. Am J Cardiol.
2005;95(6):768-71.
58: Drakos SG, Charitos CE, Ntalianis A, Terrovitis JV, Siafakas KX, Dolou P, Pierrakos C, Charitos E, Karelas
J, Nanas JN. Comparison of pulsatile with nonpulsatile mechanical support in a porcine model of profound
cardiogenic shock. ASAIO J. 2005 ;51(1):26-9.
59: Anastasiou-Nana MI, Tsagalou EP, Mavrikakis EM, Siafakas KX, Tsolakis EJ, Drakos SG, Dalianis A,
Karelas J, Terrovitis JV, Nanas JN. Myocardial ischaemic preconditioning in the pig has no effect on the
ventricular fibrillation and defibrillation thresholds. Resuscitation. 2005;64(3):373-6.
60: Anastasiou-Nana MI, Tsagalou EP, Charitos C, Siafakas KX, Drakos S, Terrovitis JV, Ntalianis A, Doufas
A, Mavrikakis J, Nanas JN. Effects of transient myocardial ischemia on the ventricular defibrillation threshold.
Pacing Clin Electrophysiol. 2005;28(2):97-101.
61: Terrovitis JV, Matsouka C, Anagnostopoulos A, Anastasiou-Nana MI, Dimopoulos AM. Hemophagocytic
lymphohistiocytosis after chemotherapy for multiple myeloma. Clin Lymphoma. 2004 ;5(3):194-6.
62: Nanas JN, Papazoglou PP, Terrovitis JV, Kanakakis J, Dalianis A, Tsolakis E, Tsagalou EP, Agrios N,
Christodoulou K, Anastasiou-Nana MI. Hemodynamic effects of levosimendan added to dobutamine in patients
with decompensated advanced heart failure refractory to dobutamine alone. Am J Cardiol. 2004 ;94(10):132932.
63: Nanas SN, Terrovitis JV, Charitos C, Papazachou O, Margari Z, Tsagalou EP, Kassiotis C, Tsolakis E,
Toumanidis S, Nanas JN. Ventilatory response to exercise and kinetics of oxygen recovery are similar in cardiac
transplant recipients and patients with mild chronic heart failure. J Heart Lung Transplant. 2004
;23(10):1154-9.
64: Grapsa E, Alexopoulos GP, Margari Z, Terrovitis JV, Kontoyannis DA, Nanas JN. Ultrafiltration in the
treatment of severe congestive heart failure. Int Urol Nephrol. 2004;36(2):269-72.
65: Terrovitis J, Charitos C, Dolou P, Papalois A, Eleftheriou A, Tsolakis E, Charitos E, Mponios M,
Karanastasis G, Koudoumas D, Agapitos E, Nanas JN. No effect of stem cell mobilization with GM-CSF on
infarct size and left ventricular function in experimental acute myocardial infarction. Basic Res Cardiol. 2004
;99(4):241-6.
66: Tsagalou EP, Anastasiou-Nana MI, Charitos CE, Siafakas CX, Drakos SG, Ntalianis A, Terrovitis JV,
Mavrikakis EM, Doufas A, Nanas JN. Time course of fibrillation and defibrillation thresholds after an
intravenous bolus of amiodarone--an experimental study. Resuscitation. 2004 ;61(1):83-9.
67: Nanas JN, Tsolakis E, Terrovitis JV, Eleftheriou A, Drakos SG, Dalianis A, Charitos CE. Moderate systemic
hypotension during reperfusion reduces the coronary blood flow and increases the size of myocardial infarction
in pigs. Chest. 2004 ;125(4):1492-9.
68: Nanas JN, Tsagalou EP, Kanakakis J, Nanas SN, Terrovitis JV, Moon T, Anastasiou-Nana MI. Long-term
intermittent dobutamine infusion, combined with oral amiodarone for end-stage heart failure: a randomized
double-blind study. Chest. 2004 ;125(4):1198-204.
69: Alexopoulos GP, Anastasiou-Nana MI, Rapti ACh, Margari ZJ, Terrovitis JV, Mitsibounas D, Makri S,
Nanas JN. Lowering of furosemide dosage after clinical stabilization in patients with congestive heart failure.
Acta Cardiol. 2003 ;58(6):513-7.
70: Terrovitis JV, Charitos CE, Tsolakis EJ, Dolou P, Pierrakos CN, Siafakas KX, Nanas JN. Superior
performance of a paraaortic counterpulsation device compared to the intraaortic balloon pump. World J Surg.
2003 ;27(12):1311-6.
71: Margari ZJ, Anastasiou-Nana MI, Terrovitis J, Toumanidis S, Agapitos EV, Lekakis JP, Nanas JN. Indium111 monoclonal antimyosin cardiac scintigraphy in suspected acute myocarditis: evolution and diagnostic
impact. Int J Cardiol. 2003 ;90(2-3):239-45.
72: Terrovitis JV, Athanasoulis T, Nanas JN. Delayed complete recovery of graft dysfunction after cardiac
transplantation. J Card Surg. 2003 ;18(1):29-31.
73: Papaioannou TG, Terrovitis J, Kanakakis J, Stamatelopoulos KS, Protogerou AD, Lekakis JP, Nanas JN,
Stamatelopoulos SF. Heart rate effect on hemodynamics during mechanical assistance by the intra-aortic balloon
pump. Int J Artif Organs. 2002 ;25(12):1160-5.
74: Anastasiou-Nana MI, Margari ZJ, Terrovitis JV, Rapti AC, Alexopoulos GP, Nanas JN. Effectiveness of
amiodarone therapy in patients with severe congestive heart failure and intolerance to metoprolol. Am J Cardiol.
2002 ;90(9):1017-9.
75: Nanas S, Nanas J, Kassiotis C, Nikolaou C, Tsagalou E, Sakellariou D, Terovitis I, Papazachou O, Drakos S,
Papamichalopoulos A, Roussos C. Early recovery of oxygen kinetics after submaximal exercise test predicts
functional capacity in patients with chronic heart failure. Eur J Heart Fail. 2001 ;3(6):685-92.
76: Papaioannou TG, Lekakis JP, Dagre AG, Stamatelopoulos KS, Terrovitis J, Gialafos EJ, Kanakakis J, Nanas
J, Stamatelopoulos SF, Moulopoulos S. Arterial compliance is an independent factor predicting acute
hemodynamic performance of intra-aortic balloon counterpulsation. Int J Artif Organs. 2001 ;24(7):478-83.
77: Nanas JN, Nanas SN, Kontoyannis DA, Moussoutzani KS, Rapti AC, Charitos CE, Terrovitis JV,
Stamatelopoulos SF, Moulopoulos SD. Limitation of infarct size by fixed coronary arterial stenosis maintained
during reperfusion. J Cardiovasc Surg (Torino). 2001 ;42(1):27-35.
78: Terrovitis IV, Nanas SN, Rombos AK, Tolis G, Nanas JN. Reversible symmetric polyneuropathy with
paraplegia after heart transplantation. Transplantation. 1998 ;65(10):1394-5.