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Digestive System Anatomy and Physiology BIO 169 Turk Digestive System Alimentary canal – gastrointestinal (GI) tract mouth, pharynx, esophagus, stomach, small intestine, and large intestine accessory digestive organs include – teeth, tongue, gallbladder, salivary glands, liver, and pancreas Digestive Processes Ingestion Propulsion – Mechanical digestion – swallowing is followed by peristalsis chewing, mixing food with saliva, churning, and segmentation Chemical digestion Absorption Defecation Digestive Processes chemoreceptors and mechanoreceptors parasympathetic enhances secretory activities and mobility sympathetic inhibits digestive activity Digestive System Organs visceral peritoneum parietal peritoneum – – peritoneal cavity Mesentery all digestive organs have four tunics – Mucosa secretes mucus, digestive enzymes, and hormones absorbs end products of digestion protects against pathogens Digestive System Organs – Submucosa – Muscularis Externa (aka muscularis) – connective tissue with blood vessels, lymph vessels, lymph nodes, and nerve fibers responsible for segmentation and peristalsis Serosa visceral peritoneum adventitia Digestive System Organs Mouth and Associated Organs – – – oral cavity or buccal cavity lined with stratified squmaous epithelium Palate – hard anterior and soft posterior Tongue lingual frenulum Filiform, fungiform, circumvallate sulcus terminalis Digestive System Organs Mouth and Associated Organs cont. – salivary glands bolus parotid, submandibular, sublingual serous cells mucous cells Amylase, mucin, lysozyme, and IgA Digestive System Organs Mouth and Associated Organs cont. – – – – – – – – Teeth Mastication deciduous teeth (baby teeth or milk teeth) Incisors, canines, bicuspids (premolars), and molars Crown is enamel covered dentin pulp Gingivitis and periodontitis Digestive System Organs Pharynx – – – oropharynx than laryngopharynx inner longitudinal muscles outer pharyngeal constrictor muscles Esophagus – – cardiac (gastroesophageal) sphincter Heartburn - hiatus hernia Digestive System Organs Esophagus cont. – Swallowing buccal phase involuntary pharyngeal-esophageal phase tongue blocks reentry into the mouth soft palate closes off the nasopharynx larynx rises so the epiglottis covers the respiratory passages peristalsis Digestive System Organs Stomach – – – – where protein digestion begins chyme (a creamy paste) rugae (folds) pyloric region is inferior and funnel shaped Digestive System Organs Stomach cont. – – gastric pits lead to gastric glands that produce gastric juices parietal (oxyntic) cells – secrete hydrochloric acid and intrinsic factor chief (zymogenic) cells produce pepsinogen (inactive form of pepsin) Digestive System Organs Stomach cont. – – mucosal barrier of bicarbonate-rich mucus gastric ulcers – pepsin is the enzyme involved in protein digestion – hypersecretion of hydrochloric acid hyposecretion of mucus Helicobacter pylori children also have rennin alcohol and aspirin Digestive System Organs Stomach cont. – – Gastrin cephalic (reflex) phase – – – triggered by sight, smell, taste, or thought of food gastric phase intestinal phase emetic center of the medulla Digestive System Organs Small Intestine and Associated Structures – – pyloric sphincter to ileocecal valve duodenum curves around the head of the pancreas – – hepatopancreatic ampulla Jejunum ileum Digestive System Organs Small Intestine and Associated Structures cont. – – plicae circulares (circular folds) Villi – simple columnar absorptive cells – Lacteal Microvilli brush border enzymes goblet cells and enteroendocrine cells duodenal glands secrete an alkaline mucus to neutralize the stomach acid entering Digestive System Organs Liver – Bile in the common hepatic duct goes to the duodenum – – – fuses with the cystic duct that drains the gallbladder to make the bile duct liver sinusoids are very leaky capillaries Kupffer cell (hepatic macrophages) process nutrients – store fat soluble vitamins – help with detoxification of the blood Digestive System Organs Liver – Hepatitis – – – – HVB, HVC, HVD HVA Cirrhosis bile contains bile salts, bile pigment, cholesterol, natural fats, phospholipids, and electrolytes bile salts emulsify fats to facilitate fat and cholesterol absorption bilirubin Digestive System Organs Gallbladder – – – stores bile not immediately needed and concentrates it cholecystokinin (CCK) gallstones Digestive System Organs Pancreas – – – – main pancreatic duct fuses with the bile duct acini – clusters of secretory cells surrounding ducts pancreatic islets (islets of Langerhans) which release insulin and glucagon pancreatic juice is alkaline Digestive System Organs Large Intestine – – – – – ileocecal valve to the anus absorb water from food residue and eliminate it as feces teniae coli Haustra Cecum with veriform appendix Digestive System Organs Large Intestine – – – – – – – – Ascending colon transerse colon descending colon sigmoid colon Rectum anal canal to the anus involuntary internal anal sphincter voluntary external anal sphincter Digestive System Organs Large Intestine – – simple columnar epithelium stratified squamous epithelium – – anal sinuses haustral contraction mass movements gastrocolic reflex defecation reflex Digestion Hydrolysis Carbohydrates – monosaccharides – – Proteins - amino acids – pepsin – works best in acidic conditions Lipids (fats) – digestion begins in the mouth (salivary amylase) pancreatic amylase in the small intestine lipases are relased by the pancrease Nucleic Acids - nucleotides Absorption active transport absorption of iron and calcium occur in the duodenum 95% of water is absorbed by the small intestine by osmosis