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SYLLABUS Academic year 2016/2017 Name of a course / module Name of a department where course is held E-mail of department Faculty of Name of a field of study Level of education Form of study Language of instruction Pharmacology Department of Pharmacology [email protected] Medicine with Division of Dentistry and Division of Medical Education in English Preclinical science Uniform master’s degree studies full time x part time Polish English x facultative obligatory x Type of course 1 2 3 4 5 x 6 x 7 8 10 11 12 Year of study / Semester I II III x IV V VI Introductory courses with preliminary requirements Number of didactic hours with specification of forms of conducting classes Student should obtained obligatory credit of physiology, biochemistry, faculty – pathophysiology, microbiology Assumptions and aims of the course Lecture – 40 Classes – 95 Upon completion of the course students will understand the general principles of drug actions in the body (pharmacodynamics). They will also demonstrate an understanding of the mechanisms of action and the effects and indications of the major therapeutic drug classes. This will provide students with the required pharmacological background for the course of pharmacotherapeutics, where drugs are discussed in the context of treating human pathology. Full name of the person conducting the course 1. providing knowledge in a form of a lecture 2. consultation (both regular and organized in individual cases) 3. discussion 4. presentation 5. other practical classes Prof. Róża Wiśniewska – MD, PhD employed scientific and teaching staff Department of Pharmacology Full name of the person responsible for teaching Prof. Róża Wiśniewska – MD, PhD PhD Edyta Gołąbiewska e-mail: [email protected] Didactic methods Symbol and number of learning outcomes according to the teaching standards and other learning outcomes Description of directional learning outcomes Form of classes Verification methods for achieving intended learning outcomes Knowledge Summarizing methods e.g., - written exam (test – form), C.W34. characteristics of particular groups of therapeutic agents; chief mechanisms of drug effect and age-dependent drug metabolism; effect of pathological processes on drug’s metabolism and elimination; basic principles of pharmacotherapy; major unwanted responses to drugs and those resulting from drug interactions; drug-resistance problem, multidrug-resistance; indications for genetic test to individualize pharmacotherapy; basic developments of therapy, specifically capabilities of cell therapy and gene therapy; basic terminology of general toxicology; drug groups, the abuse of which can cause poisoning; symptoms of typical acute poisonings; intoxication caused by alcohol, narcotics and psychotropic substances, heavy metals and other drugs; basic principles of diagnostic procedures in case of poisoning. C.W35. C.W36. C.W37. C.W38. C.W39. C.W40. C.W41. C.W42. C.W43. C.W44. C.W45. Lectures, classes descriptive examination - an essay, Forming methods, e.g., - observation of the student's work - evaluation of the activity in the classroom - completion of each activity - assessment of preparation for classes - discussion in class - partial tests Skills C.U13. C.U14. making simple pharmacokinetic calculations; administering a right medication dose in order to remedy pathological phenomena in the organism or an organ; designing a rational chemotherapeutic scheme of infections: both empirical and guided scheme; making records of all therapeutic agents prescribed; using pharmaceutical guides and therapeutic products database; estimating a toxicological risk for certain age groups and of hepatic and renal failure; preventing medicine poisoning; Social competence C.U15. C.U16. C.U17. C.U18. K1 He /She recognizes his/her own diagnostic and therapeutic limitations, educational needs, planning of educational activity He /She is able to work in a team of professionals, in a multicultural and multinational environment He /She implements the principles of professional camaraderie and cooperation with representatives of other professionals in the range of health care He /She observes doctor-patient privilege; and patient rights K2 K3 K4 ECTS points classes classes Summarizing methods e.g,. - practical examination (with simulator) - project, presentation Forming methods, e.g., - observation of the student's work - evaluation of the activity in the classroom - completion of each activity - discussion in class - partial tests Summarizing methods e.g., Continuous assessment by teachers (observation) Forming methods, e.g., - observation of the student's work - discussion in class Należy podać liczbę punktów ECTS przypisaną przedmiotowi. Student Workload 1. 2. 3. 4. 5. Form of activity Number of hours to complete the activity Classes that require the participation of a teacher Realization of the course: lectures (according to the curriculum ) 40 Realization of the course: classes (according to the curriculum ) 95 Realization of the course: seminars; (according to the – curriculum) Realization of the course: electives – Participation in consultation 15 Total hours: 135 Student self-study 1 punkt ECTS oznacza 25-30 godzin pracy studenta w różnych formach, takich jak np.: 1. Preparation for the theoretical and practical 150 2. Preparation for tests/credits 60 3. Preparation for an exam/final test-credit 100 Total hours: 310 Course contents: proszę wpisać hasłowo tematykę poszczególnych zajęć, pamiętając, aby przekładała się ona na zamierzone efekty kształcenia Learning outcomes Topics (symbol and number) Lectures: C.W34,35,36,37,38,39,40,41,42,43,44,45 Introduction to pharmacology. General Pharmacology. C.W34,35,36,37,38,39,40,41,42,43,44,45 Introduction to chemotherapy. Principles of use antimicrobial C.W34,35,36,37,38,39,40,41,42,43,44,45 agents. C.W34,35,36,37,38,39,40,41,42,43,44,45 Antibiotics - and chemotherapeutics C.W34,35,36,37,38,39,40,41,42,43,44,45 Antifungal. Antihelminthic and antiprotozoal drugs C.W34,35,36,37,38,39,40,41,42,43,44,45 Cancer therapy C.W34,35,36,37,38,39,40,41,42,43,44,45 Autonomic nervous systems – parasympathetic and sympathetic C.W34,35,36,37,38,39,40,41,42,43,44,45 pharmacology C.W34,35,36,37,38,39,40,41,42,43,44,45 Non-steroidal anti-inflammatory drugs and opioids C.W34,35,36,37,38,39,40,41,42,43,44,45 1. Principles of CNS treatment C.W34,35,36,37,38,39,40,41,42,43,44,45 2. Pharmacotherapy of neurodegenerative disorders C.W34,35,36,37,38,39,40,41,42,43,44,45 3. Antidepressants and antipsychotic drugs C.W34,35,36,37,38,39,40,41,42,43,44,45 1. General principles of endocrinology. C.W34,35,36,37,38,39,40,41,42,43,44,45 2. Introduction to diabetes mellitus. 3. Pharmacotherapy of asthma C.W34,35,36,37,38,39,40,41,42,43,44,45 4. Pharmacotherapy of gastric acidity, peptic ulcers and gastroesophageal reflux disease C.W34,35,36,37,38,39,40,41,42,43,44,45 5. Immunopharmacology C.W34,35,36,37,38,39,40,41,42,43,44,45 1. Anemias – pharmacotherapy 2. Hypertension management C.W34,35,36,37,38,39,40,41,42,43,44,45 3. Prevention, Treatment and Control of Atherosclerosis C.W34,35,36,37,38,39,40,41,42,43,44,45 4. Pharmacology of antiarrhythmic medications C.W34,35,36,37,38,39,40,41,42,43,44,45 5. Drug abuse, pharmacotherapy of pediatric and geriatric patients C.W34,35,36,37,38,39,40,41,42,43,44,45 Classes: C.W34,35,36,37,38,39,40,41,42,43,44,45 Module I: General Pharmacology. Antimicrobial, cancer and C.W34,35,36,37,38,39,40,41,42,43,44,45 immunosuppresive pharmacology. C.W34,35,36,37,38,39,40,41,42,43,44,45 C.W34,35,36,37,38,39,40,41,42,43,44,45 General Pharmacology. Pharmacodynamics Pharmacokinetics (calculations) Chemotherapy C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 A/ Principles of Antimicrobial Use B/ Beta-Lactam Antibiotics & Other Cell Wall- & MembraneActive Antibiotics C/ Tetracyclines, Macrolides, Clindamycin,Chloramphenicol, & Streptogramins C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 D/ Aminoglycosides & Spectinomycin Chemotherapy A/ Sulfonamides, Trimethoprim, & Quinolones B/ Antimycobacterial Drugs C/ Antiprotozoal & Antihelminthic Drugs Chemotherapy A/ Antifungal Agents C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 B/ Antiviral Agents C/ Miscellaneous Antimicrobial Drugs Cancer chemotherapy A/ Antibiotics used in clinical situations C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 B/ Cancer chemotherapy Quiz 1- Module I C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 C.W34,35,36,37,38,39,40,41,42,43,44,45, C.U13,14,15,16,17,18 Obligatory textbook: (1-2 pozycje) Module II: Pharmacology of autonomic nervous system and central nervous system, analgetic drugs. Parasympathetic Pharmacology Sympathetic Pharmacology Analgetic drugs: non-steroidal anti-inflammatory drugs and opioid drugs. CNS (Part I): Pharmacology of local and general anesthetics.Drugs used in neurodegenerative disorders (Alzheimer, Parkinson’s disease) CNS (Part II): Sedative and hypnotic drugs. Antiseizure agents CNS (Part III): Antidepressants agents. Antipsychotic drugs and Lithium. Drug abuse. Drugs used in treatment of pain Quiz 2- Module II Module III: Endocrine pharmacology, other systems, special topic. Endocrine drugs A/ Pituitary and hypothalamic hormones B/ Drugs used in the treatment of hypothalamic, pituitary, adrenal disorders Endocrine drugs A/ Thyroid, adrenal hormones B/ Drugs used in the treatment of diabetes mellitus, errors of glucose metabolism and thyroid disorders Endocrine drugs A/ Calcium-regulating hormones B/ Hormones of the reproductive system C/ Drugs used in the treatment of bone and calcium disorders D/ Drugs used in reproductive endocrinology Other system and special topics A/Autacoids. Antihistaminic drugs. B/ Immunosuppressive drugs and drugs used in rheumatoid arthritis and gout Other system and special topics A/ Drugs used in the treatment of asthma, chronic obstructive pulmonary disease and allergies Other system and special topics A/ Drugs used in the treatment of gastrointestinal disorders Quiz 3- Module III Module IV – Cardiovascular pharmacology Cardiovascular drugs A/ Agents used in anemias B/ Hematopoietic growth factors C/ Drugs used in disorders of coagulation ( anticoagulant, thrombolytic, antiplatelet) Cardiovascular drugs A/ Antihypertensive agents B/ Diuretics Cardiovascular drugs A/ Vasodilators B/ Drugs used in the treatment of angina pectoris C/ Agents used in hyperlipidemia Cardiovascular drugs A/ Drugs used in heart failure B/ Antiarrhythmic drugs Quiz 4- Module IV Basic and clinical pharmacology 11th or 12th Ed. B.C. Katzung (2012 or 2015) McGraw Hill/ Appleton& Lange Lippincott's Illustrated Reviews: Pharmacology, 5 th Ed. (2011), Wolters Kluwer Optional textbook: (1-2 pozycje) Goodman and Gilman’s The Pharmacology Basis of Therapeutics 12 th Ed. (2010) Hardman, et. al McGraw Hill Pharmacology, George M. Brenner, 4th Ed. (2013) Elsevier Criteria for assessing the achieved learning outcomes and the form and conditions for receiving credit: 1. The internal regulations of the Department of Pharmacology are in compliance with the Study Regulations of the Medical University of Bialystok. All lectures and laboratory classes are obligatory. 2. Course of Pharmacology is conducted in the form of lectures and classes and 4 Module Tests (consisting of 20 multiple choice questions with only one correct answer per question). Test evaluated according to the scale: failed 60%, satisfactory – 60-69% of points, fairly good – 70-79% of points, good – 80-89% of points, more than good 90-95%, very good 96% Students who fail to achieve a grade of 60% of the Module Test for the first time, they have the ability to retake (only one time) (form of the retake exam: open questions) within a fixed time, but no later than 2 weeks after the Module Test. The times of the Module Tests will be scheduled by the assistants and displayed on the notice board and department website:http://www.umb.edu.pl/en/wl/zaklad-farmakologii. Students who fail the retake Module Test will receive 2 negative points (-2) 3. In each class students will receive a credit by answering questions concerning the material that was required to learn prior to class. The grade will be recorded as Pass/Fail. 4. Students who were absent on classes or lectures have to pass the class within 2 weeks. The form of assessment is 3 open questions prepared by assistant. Moreover, students are required to bring sick leave or Dean’s leave in the next week and present it to the assistant before the class or lecture (scan, xero or picture sent to the Pharmacology Department e-mail are also accepted). 5. Students who failed assessment of the class will receive 1 negative point (-1). Students who failed assessment of lecture will receive 0.5 neagtive point (-0.5). Negative points will be charged for each failed class and lecture 6. If student will obtain 6 negative points during the academic year (lectures, classes, Module Tests), it will result in the failure to the examination session. 7. The final written exam covers material of lectures, exercises and indicated for self-preparation. Students are permitted to take the Final Exam if they have successfully completed semesters in the 3rd years. The Final Examination will consist of a multiple choice test with only one correct answer per question. The exam is evaluated according to the scale: < 60% 60-69% 70-79% – 80-89% 90-95% – > 96% - failed (2) satisfactory (3) fairly good (3.5) good (4) more than good (4.5) very good (5) 8. Students who obtained from 1 to 2 negative points are admitted conditionally to the Final Exam according to the scale: 69 70-74% 75-80% – 81-89% 90-95% – 96% - failed (2) satisfactory (3) fairly good (3.5) good (4) more than good (4.5) very good (5) 9. Students who obtained from 3 to 5 negative points are admitted conditionally to the Final Exam according to the scale: 79% 80-84% 85-89% – 90-94% 95-99% – 100% - failed (2) satisfactory (3) fairly good (3.5) good (4) more than good (4.5) very good (5) 10. The retake of the Exam (both the first and second term of the retake) will consist of open questions (no test) excluding the negative points according to the scale: < 60% 60-69% 70-79% – 80-89% 90-95% – > 96% - failed (2) satisfactory (3) fairly good (3.5) good (4) more than good (4.5) very good (5) 20.09.2016 (date and signature of the person preparing the syllabus) Prof. dr hab. n. med. Róża J. Wiśniewska (date and signature of the Head of the Department where the course is held) and Prof. dr hab. n. med. Róża J. Wiśniewska (course coordinator)