* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download High Resolution Biomedical Imaging with Light and Sound
Ellipsometry wikipedia , lookup
Optical rogue waves wikipedia , lookup
Hyperspectral imaging wikipedia , lookup
Terahertz radiation wikipedia , lookup
Magnetic circular dichroism wikipedia , lookup
Vibrational analysis with scanning probe microscopy wikipedia , lookup
Fiber-optic communication wikipedia , lookup
Optical amplifier wikipedia , lookup
Photon scanning microscopy wikipedia , lookup
Interferometry wikipedia , lookup
Passive optical network wikipedia , lookup
Photoacoustic effect wikipedia , lookup
Silicon photonics wikipedia , lookup
Imagery analysis wikipedia , lookup
Optical tweezers wikipedia , lookup
Nonlinear optics wikipedia , lookup
Confocal microscopy wikipedia , lookup
3D optical data storage wikipedia , lookup
Ultrafast laser spectroscopy wikipedia , lookup
Chemical imaging wikipedia , lookup
Super-resolution microscopy wikipedia , lookup
Preclinical imaging wikipedia , lookup
Photoacoustic Microscopy: High Resolution Biomedical Imaging with Light and Sound Takashi Buma Department of Electrical & Computer Engineering, Union College High resolution imaging systems are invaluable tools for biomedical research and clinical practice. Photoacoustic microscopy (PAM) is an emerging hybrid technique that can overcome the limitations of conventional optical and ultrasonic imaging modalities. A pulsed laser illuminates tissue, where optical absorption and transient thermal expansion leads to ultrasound emission. Image contrast is based on the naturally occurring (endogenous) optical absorption in tissue. Spatial resolution and penetration depth are determined by the ultrasonic properties of tissue. Performing PAM at multiple laser wavelengths can produce valuable spectroscopic information that differentiates various tissue types. The Biomedical Ultrasonics & Biophotonics Laboratory (BUBL) at Union College is developing rapidly tunable pulsed lasers for high-speed spectroscopic PAM. We are currently investigating nonlinear fiber optics, particularly stimulated Raman scattering and four wave mixing, to produce a multi-color output from a single wavelength laser. We have demonstrated multi-color pulsed lasers operating at visible and nearinfrared wavelengths for potential applications in mapping blood oxygenation in capillaries and visualizing atherosclerotic plaques. Takashi Buma received his B.S.E. in Electrical Engineering with a certificate in Engineering Physics from Princeton University in 1995. He received his Ph.D. in Applied Physics from the University of Michigan in 2002, where his research in the Biomedical Ultrasonics Laboratory explored optical techniques to generate and receive high frequency ultrasound. He then joined the Center for Ultrafast Optical Science at the University of Michigan to perform research in time-domain terahertz imaging systems. He was an Assistant Professor of Electrical and Computer Engineering at the University of Delaware from 2005 to 2011. In the fall of 2011, he joined the faculty of Union’s ECE Department and Bioengineering Program. His research interests include photoacoustic microscopy, device and systems development for high frequency ultrasound imaging, and optical coherence tomography.