Download photoacoustic imaging to detect tumor

PHOTOACOUSTIC IMAGING
TO DETECT TUMOR
HAIFENG WANG
SUBHASHINI PAKALAPATI
VU TRAN
Department of Electrical and Computer Engineering
University of Massachusetts Lowell
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OUTLINE
 Introduction
 Brief
 Principle of Photoacoustic (PA)
 Different Techniques of PAI
 Comparison of Various Imaging Techniques
 Advantages and Disadvantages
 Tasks
 Reference
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Brief
Conversion of photons to acoustic waves due
to absorption and localized thermal
excitation.
Pulses of light is absorbed, energy will be
radiated as heat.
Heat causes detectable sound waves due to
pressure variation.
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Introduction of Ultrasound
Ultrasound applications:
Low bass notes
20Hz
Infrasound
Medical and Destructive
20KHz
Acoustic
Diagnostic and
Nondestructive Testing (NDT)
2MHz
200MHz
Ultrasound
Ultrasound in optical fibers
Optical fiber ultrasound generator
125 µ m
Optical fiber ultrasound detector
Laser induced optical fiber
ultrasound generator - receiver
Principle of photoacoustic
Energy absorption layer
Laser excitation
Optical fiber
Acoustic signals
• The light energy is converted into thermal energy via
energy absorption layer;
• The thermal energy converts into mechanical wave
because of thermal expansion;
• An acoustic wave is generated.
Principle of photoacoustic by
gold nanoparticle
Energy absorption layer
Laser excitation
Optical fiber
Laser pulse
Gold
nanoparticle
Acoustic signals
Sound pulse
Principle of photoacoustic by
cells or tissues[1]
Experimental set up of
photoacoustic molecular
imaging[2]
Angiogenesis
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Tumor Detection Using Endogenous
Contrast
Xueding Wang, William W. Roberts, Paul L. Carson, David P. Wood and J. Brian Fowlkes,
Photoacoustic tomography: a potential new tool for prostate cancer, 2010 :Vol. 1, No. 4 :
Biomedical Optics Express 1117
Using Exogenous Contrast
• 3-D photoacoustic imaging
• Evans Blue acted as a contrast agent.
• Deep lying blood vessels in real tissue
samples were imaged at depths of 5 mm
and at 9 mm from the plane of detection.
• The sensitivity of the technique was
proven by photoacoustic detection of
single red blood cells upon a glass plate
C.G.A Hoelen et.al,1998
PAImaging Using Gold Nano
Particles
Qizhi Zhang et.al,2010
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Qizhi Zhang et.al.,2010
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COMPARISON OF DIFFERENT IMAGING
TECHNIQUES:
ULTRASOUND
 Transducer emit ultrasound wave and get signals
back from object
 D= t.v
 Scan volume to get image
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COMPUTED TOMOGRAPHY
 Use X-ray to collect data
 Detector collects the sum of
absorption factors in one direction
 Using the computing algorithms, the
absorption factor of each voxel will
be calculated.
 3D image will be constructed based
on these factors.
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MRI
 A powerful magnetic field is used to
align the magnetization of Hydrogen
atoms in the body
 Radio frequency fields are used to alter
the alignment of this magnetization
 Nuclei to produce a rotating magnetic
field detectable by the scanner
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POSITRON EMISSION TOMOGRAPHY
 Positron-emitting radionuclide
(tracer) is introduced into the body
on a biologically active molecule
 System detects pairs of gamma
rays emitted indirectly by a tracer
 Three-dimensional images of
tracer concentration within the
body are then constructed by
computer analysis
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SINGLER PHOTON EMISSION
COMPUTED TOMOGRAPHY
• A gamma-emitting radioisotope is
injected into the bloodstream of
the patient
• A marker radioisotope has been
attached to a special radioligand
(chemical binding properties to
certain types of tissues)
• The ligand concentration is
detected by a gamma-camera
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ADVANTAGES
DISADVANTAGES
1. Ability to detect deeply
situated tumor and its
vasculature
2. Monitors angiogenesis
3. High resolution
4. Compatible to Ultra Sound
5. High Penetration depth
6. No radioactive
7. Small size
8. Easy to clean and
maintenance
9. No noise
1. Limited Path length
2. Temperature Dependence
3. Weak absorption at short
wavelengths
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TASKS
– To Refine and improve the paper.
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THANK YOU
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