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بسم هللا الرحمن الرحيم Choose the correct answer for questions (1 – 90 ) 1. Increased serum a level of which of the following is associated with a decreased risk of atherosclerosis? a) Cholesterol d) Triglyceride b) LDL e) VLDL c) HDL 2. The active ingredient in Tinasil is a) Fexofenadine d) Dimethindene b) Naftifine e) Amlodipine c) Terbinafine 3. The manufacturer of Tinasil is a) Birzeit d) Jerusalem b) Pharmacare e) Gama c) Beit jala 4. Tinasil is a) Antiangina b) Anti-inflammatory c) Antiviral d) Antimalaria e) Antifungal 5. Which of the following have been shown to be effective in the acute management of digitalis toxicity ? a) Cholestyramine resin d) A and B b) Fab fragment antibody e) All c) Potassium administration 6. What are the most common adverse effects of anticonvulsive drugs? a) Headache and dizziness b) Gastrointestinal symptoms c) Adverse effects on appetite and body weight d) Alteration of cognition and mentation e) All of the above 7. in the emergency department, the preferred first-line therapy for asthma exacerbation is a) theophylline d) a corticosteroid b) a B-agonist e) cromolyn sodium c) an antihistamine 8. Current criteria used in the diagnosis of diabetes mellitus (DM) include all of the following symptoms EXCEPT a) Fasting hyperglycemia d) polydipsia b) Polyuria e) tinnitus c) weight loss 9. Sulfonylurease are a primary mode of therapy in the treatment of a) Insulin-dependent (type 1) diabetes mellitus (IDDM) patients b) Diabetic patients experiencing severe hepatic or renal dysfunction c) Diabetic pregnant women d) Patients with diabetic ketoacidosis e) Non-insulin-dependent (type 2) DM (NIDDM) patients 1 10. Exjade is an antidote that is used in case of --------------- poisoning: a) Iron d) Calcium b) Heparin e) None of the above. c) Paracetamol 11. The thyroid gland normally secretes which of the following substances into the serum ? a) Thyrotropin-releasing hormone (TRH) b) Thyrotropin (thyroid-stimilating hormone) c) Diiodothyronine (DIT) d) Thyroglobulin e) Thyroxine (T4) 12. Potential adverse effects associated with aspirin include all of the following EXCEPT: a) Gastrointestinal ulceration b) Renal dysfunction c) Enhanced methotrexate toxicity d) Cardiac arrhythmias e) Hypersensitivity asthma 13. All of the following facts are true about nonsteroidal anti-inflammatory drugs (NSAIDs) EXCEPT a) They are antipyretic b) There is a ceiling effect to their analgesia c) They can cause tolerance d) They do not cause dependence e) They are anti-inflammatory 14. A common adverse effect of thrihexyphenidyl is: a) Insomnia b) Nausea and vomiting c) Dry mouth and urinary retention d) Depression e) Anorexia 15. Which inhibits monoamine oxidase (MAO)? a) Benztropine d) Pramipexole b) Bromocriptine e) Selegiline c) Tolcapone 16. How does carbidopa affect levodopa ? a) Slows the release from presynaptic neurons b) Prevents the excretion of dopamime receptors c) Increases stimulation of dopamime receptors d) Decreases tolerance to normal doses e) Inhibits the peripheral conversion to dopamine 17. Acetylcysteine is used to treat overdoses of a) Benadryl d) Aspirin b) Ayds e) No Doz c) Acetaminophen 2 18. Long-acting topical nasal decongestants share which of the following properties? a) They are sympathomimetic agents b) They are likely to produce rebound congestion with prolonged use c) Their effects last for more than 24 hours d) A and B e) B and C 19. Which of the following drugs is available over-the-counter for the treatment of nausea and vomiting? a) Dimenhydrinate d) Prochlorperanzine b) Perphenazine e) Scopolamine c) Danthron 20. Predisposing causes of hemorrhoids include all of the following EXCEPT a) Prolonged standing d) high-fiber diet b) heredity e) inadequate fluid intake c) diarrhea 21. How many grams of water are needed to make 150 g of a 4% w/w solution of potassium acetate? a) 100 d) 135 b) 130 e) 144 c) 156 22. The term bioavailability refers to the a) Relationship between the physical and chemical properties of a drug and the systemic absorption of the drug b) Measurement of the rate and amount of therapeutically active drug that reaches the systemic circulation c) Movement of a drug into the body tissues over time d) Dissolution of a drug in the gastrointestinal tract e) Amount of drug destroyed by the liver prior to systemic absorption from the gastrointestinal tract 23. The passage of drug molecules across a cell membrane from a region of high drug concentration to a region of low drug concentration is known as a) Active transport b) bioavailability c) biopharmaceutics d) passive diffusion e) pinocytosis 24. The following patient instructions are necessary when prescribing Co-Trimoxasole suspension:a) Shake well before use. b) Take medicine with plenty of fluids. c) Exposure to sunlight may cause adverse reactions. d) a + b e) All of the above 25. All of the following drugs are classified as Anti-Viral except:a) Amantadine d) Amikacin b) Ribavirin e) Peginterferon alfa-2a c) Acyclovir 3 26. The following Tetracycline has the longest duration of action a) Doxycycline d) Minocycline b) Tetracycline e) Oxytetracycline c) Demeclocycline 27. The following drug is classified as a narcotic antagonist a) Butorphenol d) Naloxone b) Buprenorphine e) Sufentanil c) Nalbuphine 28. Which of the following is true concerning regular insulin: a) It is a clear product. b) It may be administered either SC or IV. c) It is a short acting insulin. d) It is a rapid acting insulin. e) All of the above. 29. Dormicum contains the following active ingredient: a) Meropenem d) Propofol b) Midazolam e) Promethazine c) Bupivacaine 30. Norvasc is manufactured by: a) Pfizer b) Wyeth c) Novartis. d) Astra Zeneca e) Abbot 31. The active ingredient in Lioresal is: a) Propofol b) Baclofen c) Leucovorin d) Levofloxacin e) Lithium carbonate. 32. When considering the appropriateness of Metformin monotherapy for a patient type II diabetes mellitus, relevant patient factors to consider include: I. Obesity II. Renal dysfunction. III. Thyroid function. a) I only d) II and III only b) III only. e) I, II and III. c) I and II only. 33. Auxiliary labeling for Clarithromycin suspension includes which of the following: a) Shake well before use. b) Take with plenty of fluids. c) Avoid prolonged exposure to sunlight. d) Keep refrigerated. e) May cause discoloration of urine. 4 with Read the following prescription carefully, then answer questions (34-36) Mepral 20 mg cap 20mg I x dly 34) The active ingredient in the drug Mepral is: a) Metronidazole. d) Esomeprazole. b) Sulpride. e) Famotidine c) Omeprazole 35) Mepral is manufactured by: a) JPH b) BPC c) Pharmacare d) JCL e) Belpharm 36) According to the prescription the drug should be administered as follows: a) One tab daily. d) One tab four times daily. b) One tab twice daily. e) None of the above. c) One tab three times daily. 37) Which of the followings is not correct: a) Orazole = Ketoconazole b) Rafassal = Sulphasalazine. c) Cellecept = Cyclosporine. d) Rocephin = Ceftriaxone. e) Zitrocin = Azithromycin. 38) Read the following prescription carefully then calculate the volume of the solution that the patient need for 20 days:- Rx a) b) c) d) e) Morphine Sulphate Solution 5mg/ml q 4h For 20 days 20ml 60ml 80ml 100ml 120ml 39) All of the following drugs should be avoided during pregnancy except:a) Narcotics b) Barbiturates c) Diazepam d) Acetaminophen e) None of the above 40) Pareteral products with an osmotic pressure greater than that of blood or 0.9% sodium chloride are referred to as: a) Isotonic solutions b) Hypertonic solutions c) Hypotonic solutions d) Iso-osmotic solutions e) Neutral solutions 5 41) Molarity is defined as:a) Gram molecular weight of solute in 1 liter of solution b) Gram equivalent weight of solute in 1 liter of solution c) Saturated solution of a solute in 1 liter of solution d) ml of solvent required to dissolve 10 grams of solution e) Supersaturated solution of a solute Read the following prescription then answer questions from (42-47) Zitrocin 200mg/5ml Pwdr for Susp 10mg/Kg dly for III days 15ml bottle 42) Zitrocin is the trade name for the following drug: a) Amoxycillin d) Roxithromycin b) Cefuroxin e) Ceftriaxone c) Azithromycin 43) Zitrocin is classified as a: a) Penicillin antibiotic b) Cephalosporin antibiotic. c) Macrolide antibiotic d) Tetracycline e) Quinalone 44) Zitrocin is manufactured locally by the following company:a) JPH d) Belpharm b) BPC e) JCL c) Pharmacare 45) A drug that contains the same active ingredient as Zitrocin is: a) Augmentin d) Zinacef b) Azenil e) Rulid c) Zinnat 46) According to the prescription, the single daily dose for a child weighing 20 Kg is:a) 2.5 ml d) 15 ml b) 5 ml e) None of the above c) 10 ml 47) According to the prescription, the total dose for a child weighing 20 Kg is:a) 15 ml d) 30 ml b) 20 ml e) 35 ml c) 25 ml 48) Factors that determine bioequivalence of two brands of a drug include:I. The taste of the preparations II. The physical appearance of the preparations. III. Pharmacokinetic parameters of the preparations. a)I only d) I and II only b) III only e) II and III only c) I, II, and III 6 49) Clofibrate is classified as a/an: a) ACE inhibitor b) Lipid lowering agent c) Antihypertensive agent d) Beta blocker e) Immuno-suppressive agent 50) The active ingredient in the drug Prograf is: a) Cyclosporine d) Piroxicam b) Tacrolimus e) Sirolimus c) Tamoxifen 51) Prednisolone may cause all of the following effects except:a) Skeletal muscle weakness b) Hypoglycemia c) Sodium retention d) Peptic ulceration e) Lowered resistance to infections 52) A package insert lists a drug dose for a neonate as being 10 mcg/kg/ day. The age range for a neonate is considered to be : a) birth to 1 month b) 1 month to 6 months c) 1 month to 1 year d) birth to 1 week e) 1 year through 5 years 53) INR: 1. is monitored in patients with arthritis 2. is monitored in patients receiving warfarin 3. stands for international normalised ratio a) 1, 2, 3 d) 2, 3 only b) 1, 2 only e) 1 only c) 3 only 54) When administered at the same time , antacids can decrease the therapeutic efficacy of which of the following drugs ? a) Sucralfate d) B and C b) Ranitidine e) A , B and C c) Cimetidine 55) Specific therapy for an acute extrapyramidal reaction to chlorpromazine is a) Physostigmine d) bethanechol b) Diphenhydramine e) propranolol c) metoclopramide 56) Rectal suppositories intended for adult use usually weight approximately a) 1 g d) 3 g b) 2 g e) 4 g c) 5 g 57) All of the following preparations contain alcohol EXCEPT a) Syrup USP b) Terpin hydrate elixir USP c) Aromatic ammonia spirit USP d) Green soap tincture USP e) Eriodictyon fludextract NF 7 58) Which of the following capsule sizes has the smallest capacity? a) 5 d) 1 b) 4 e) 0 c) 000 59) A satisfactory suppository base must meet all of the following criteria EXCEPT a) It should have a narrow melting range b) It should be nonirritating and nonsensitizing c) It should dissolve or disintegrate rapidly in the body cavity d) It should melt below 30 C e) It should be inert 60) A prescription label should contain all of the following EXCEPT a) Quantity dispensed b) Lot number c) Patient diagnosis d) Expiration date e) Physician name 61) Which of the following substances when present in urine is the most likely positive sign of pregnancy? a) Thyroid-stimulating hormone (TSH) b) Corporation (ACTH) c) Human Chorionic gonadotropin (HCG) d) Interstitial cell-stimulating hormone (ICSH) e) Protamine zinc insulin (PZI) 62) All of the following substances are endogenous tropic hormones secreted by the pituitary gland EXCEPT a) somatotropin b) human chorionic gonadotropin (HCG) c) follicle-stimulating hormone (FSH) d) thyroid-stimulating hormone (TSH) e) corticotrophin (ACTH) 63) The pH value is calculated mathematically as the a) Log of the OH- concentration b) Negative log of the OH- concentration c) Log of the H+ concentration d) Negative log of the H+ concentration e) Ratio of H+/OH- concentration 64) Which of the following tissues has the greatest capacity to biotransform drugs? a) Brain d) liver b) Kidney e) lung c) Skin 65) The active ingredient in Trovan is a) Simvastatin b) Atrovastatin c) Fluvastatin d) Pravastatin e) Ciprofibrate 8 66) The manufacturer of Trovan a) Birzeit b) Pharmacare c) Gama d) Beit jala e) Jerusalem 67) Which brand name – generic name combinations are correct? a) Feldene – meclofenamate. b) Vioxx – celecoxib. c) Naprosyn – naproxen. d) a and b. e) b and c. 68) Which substance should be used in a case of overdosage with methotrexate (MTX)? a) Brewer's yeast. b) Leucovorin. c) Para- aminobenzoic acid. d) Sulfisoxazole. e) Trimethoprim. 69) OTC cold and allergy products often contain a combination of active ingredients. An OTC product that contains guaifenesin, pseu-doephedrine, and dextromethorphan would have a) Antihistamine, decongestant, and antitussive activity. b) Expectorant, decongestant, and antitussive activity. c) Demulcent, antitussive, and antihistamine activity. d) Expectorant, demulcent, and antitussive activity. e) Antitussive, decongestant, and demulcent activity. 70) A friend of yours has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked) and increased hair growth. Which of the following is most likely to produce the effects your friend has described? a) Captopril d) Minoxidil b) Guanethidine e) Prazocin c) Propranolol 71) Which drug is a substituted imidazole for treating many systemic fungal infections and is an effective agent taken orally? a) Butoconazole. b) Clotrimazole. c) Ketoconazole. d) Miconazole. e) Nystatin. 72) True comparisons of Trufen to Otamol include a) Otamol has less anti- inflammatory activity than Trufen b) Otamol is contraindicated in children because they are susceptible to Reye's syndrome. c) Otamol l irritates the gastrointestinal tract more than Trufen d) a & b e) c & a 9 73) A visitor from another city comes to your pharmacy complaining of incessant cough. He has diabetes and hypertension and has recently taking a new antihypertensive medication. The most likely cause of his cough is a) Enalapril b) Losartan c) Minoxidil d) Propranolol e) Verapamil 74) Which of the following are true regarding Helicobacter pylori? a) It is present in the majority of patients with duodenal ulcer. b) H. pylori eradication can cure peptic ulcer disease and reduce ulcer recurrence. c) Treatment of active duodenal ulcer is best managed with a combination of antisecretory therapy plus appropriate antibiotic (s). d) A & c e) All of above. 75) Which of the following matches is not true? a) Coxib – etoricoxib b) Sinagra - Sildenafil c) Adcef - Cefdinir d) Movalis - Meloxicam e) Zydex – fusidic acid 76) Enythropoietin procrit is used in chronic renal failure to treat? a) Peripheral neuropathy. b) Anemia. c) Hyperphosphatemia. d) Metabolic alkalosis. e) Hyperuricemia 77) The active ingredient in Exforge is a) Amlodipine b) Valsartan c) Nifedipine d) a + b e) a + c 78) The manufacturer of Exforge is a) Pfizer b) Glaxo c) Novartis d) CTS e) Dexxon 79) Lucast (montelukast sodium) is indicated for a) prophylaxis of asthma b) chronic treatment of asthma c) relief of symptoms of seasonal allergic rhinitis d) a + b e) all of the above 10 80) The manufacturer of Lucast is a) Birzeit b) Pharmacare c) Beit jala d) Jerusalem e) Gama 81) Nystatin suspension is used as prophylaxis against which organism? a) Histoplasma capsulatum. b) Candida albicans. c) Pneumocystis carinii. d) Pseudomonas aeruginosa. e) Staphylococcus aureus 82) A patient allergic to penicillin group of antibiotics has to avoid a) Klacid b) Azenil c) Doxacin d) Denacine e) Drypen 83) The active ingredient in Acidex Complete a) Famotidine b) Magnesium Hydroxide c) Calcium Carbonate d) b + c e) All of the above 84) The manufacturer of Acidex Complete is a) Birzeit b) Pharmacare c) Beit jala d) Jerusalem e) Gama 85) The active ingredient in Crestor is a) Bezafibrate b)Colestipol c) Rosuvastatin d) Fluvastatin e) Atrovastatin 86) The manufacturer of Crestor is a) Pfizer b) Glaxo c) Novartis d) Lapidot e) AstraZeneca 11 87) The most likely cause of death associated with an overdose of acetaminophen is a) Arrhythmia b) Hemorrhagic stroke c) Liver Failure d) Noncardiogenic pulmonary edema e) Ventilatory failure 88) Aspirin overdose is characterized by a syndrome of a) Bone marrow dysfunction and possibly aplastic anemia. b) Fever, hepatic dysfunction and encephalopathy c) Hyperthermia, metabolic acidosis, and coma d) Rapid, fulminant hepatic failure e) Rash, interstitial nephritis and acute renal failure 89) Ingestion of which of the following vitamins should be avoided by a patient taking the oral anticoagulant warfarin? a) Vitamin A b) Vitamin B c) Vitamin D. d) Vitamin E. e) Vitamin K. 90) Creatinine clearance is a measurement of : a) Glomerular filtration rate (GFR). b) Active tubular secretion. c) Muscle metabolism. d) Hepatic function. e) Effective renal plasma flow. :)911-19( أجب بنعم أو ال على األسئلة من ) ( . يجوز للصيدلي أن يكون مالكا ألكثر من مؤسسة صيدالنية واحدة.19 ) ( . متر مربع04 يجب أن ال تقل مساحة الصيدلية عن.19 ) ( . مستودع األدوية مخصص لبيع األدوية بالجملة و المفرق ألي كان.13 شهرا فقط حسب األصول بسبب سفره إلى الخارج و عندما رجع له الحق91 صيدلية أغلقها صاحبها لمدة.10 ) ( .بإعادة فتحها و ممارسة عمله ) ( يجوز أن يكون تاريخ انتهاء الدواء مختوما بالحبر أو مطبوعا من قبل الشركة الصانعة.11 ) ( . ال يجوز أن يكون للصيدلية العامة باب فرعي آخر يتصل بمنزل الصيدالني المسئول.19 ) ( . يجوز حقن اإلبر في الصيدلية من قبل أي كان. 19 ) ( . ال يجوز أن يكون باب الصيدلية الخاصة التابعة لجمعية خيرية على الشارع العام.19 . يجوز للصيدلي المالك و المسئول عن الصيدلية العمل كمندوب دعاية باإلضافة إلى عمله في الصيدلية.11 ( ) ) ( . يلغى الترخيص الممنوح من الوزارة في حال تم بيع الصيدلية دون علم و موافقة الوزارة.944 مع تمنياتنا لكم بالنجاح 12