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MCMP 422
IMMUNOLOGY
Spring 2006
Course Coordinator:
Participating Faculty:
Dr. Geahlen (HANS 431A, 494-1457)
Dr. Harrison (HANS 431D, 494-1442)
Dr. Hazbun (RHPH 406D, 496-8228)
LEARNING OBJECTIVES
General
The objectives of Immunology (MCMP 422) are to expose the student to the basic principles of immunology
and to enable the student to use those principles to understand how the immune system combats infections, the
causes of immunological diseases and the basis of immunoprophylaxis and immunotherapy. These objectives
will be achieved through class lectures and out of class reading assignments. The student will be expected to
understand basic immunological concepts and to apply this knowledge to solving problems involving the
integration of the various components of the immune system. The integrity of the immune system is essential to
human health and many drugs either directly or indirectly target immune cells. In addition, drugs are often used
to manipulate the immune system to suppress or enhance its function. It is, therefore, essential for the
pharmacist to understand the basis of immunology and the consequences of either suppressing or enhancing
immune function.
Specific
At the end of the course, the student should be able to discuss the following topics:
1. The basic components of the immune system and their roles in innate and adaptive immunity
2. The development and function of lymphocytes in adaptive immunity
3. The molecular basis of antibody diversity
4. How antigens are recognized by T cells
5. How B cells develop and function in the body
6. How T cells develop in the body and differentiate into specialized subsets
7. How lymphocytes undergo positive and negative selection
8. How B cells and T cells are activated and participate in adaptive immunity
9. The basis of MHC polymorphism and its role in the immune response
10. How the complement system is activated and plays a its role in immune responses
11. How the cellular components of the innate and adaptive immune systems combine to generate an effective
response against pathogens
12. How the body remembers a previous infection
13. The types and causes of immunodeficiency diseases
14. How infection with HIV affects the immune system
15. How the immune system sometimes recognizes harmless antigens (allergic reactions).
16. How the immune system can damage healthy tissue
17. The basis and practice of immunization
18. How the immune system complicates organ transplantation
19. How the immune system can be used to combat cancer
20. How immunodeficiency diseases can be reversed by gene therapy
21. How products of the blood can be used therapeutically
COURSE POLICIES
Course Assessments and Grading
There will be four required one-hour examinations, 100 points each, for a total of 400 points and one 200point comprehensive final examination. Because the final is comprehensive, any hour exam grade lower than
one half of the final exam grade will be replaced by the final exam grade divided by two. Additional points
may also be made available upon completion of instructor and course evaluations. Grades will be assigned on
the following straight scale:
Points
600-540
539-480
479-420
419-360
359-0
Percentage
90%
80%
70%
60%
59%
Grade
A
B
C
D
F
Any questions regarding the grading or scoring of any individual exam must be brought to the attention of
teaching assistants and faculty within two weeks of the exam date.
Make-up Exams
There will be no make-up examinations. However, we expect all students to take all four hour exams.
Students unable to take an exam must have an excused absence certified by the Associate Dean for
Professional Programs and must notify the current course instructor prior to the time of the exam. Unexcused
absences resulting in failure to take an exam will result in 0 points being assigned for that exercise. Such
exams will not be eligible for replacement by ½ the final exam score.
Academic Dishonesty
Academic dishonesty in MCMP 422 is defined as the unauthorized use of any method or materials before or
during an examination that gives the user an unfair advantage over his/her classmates. Academic dishonesty
includes, but is not limited to: 1) copying from another exam during the examination period; 2) allowing your
exam to be seen by a classmate during the examination period; 3) using notes or crib sheets during the
examination; and 4) altering an examination prior to a regrade. The penalty for any act of academic
dishonesty in MCMP 422 is an automatic F grade for the ENTIRE course.
Professionalism Standards
In accordance with Professionalism Standards adopted by the School of Pharmacy, students should refrain
from participating in any unprofessional conduct that is disruptive or threatening to instructors or other
students or that inhibits or diminishes the opportunity for other students to learn in the classroom.
Copyrights and Note Taking Services
All handouts given in this course or provided via course websites or audio recordings of lectures are
considered as copyrighted materials and cannot be reproduced and distributed. The sale of distributed course
material (hardcopy or electronic) for profit by note-taking services violates all rules regarding the protection
of intellectual creativity. The taking of notes by the student in the lecture room is a proven method of learning;
those students who try to “short cut” this method are subjecting themselves to the errors introduced into the
subject by an untrained individual.
Adaptive Program Registration
Students with disabilities must be registered with Adaptive Programs in the Office of the Dean of Students
before classroom accommodations can be provided. If you are eligible for academic accommodations because
you have a documented disability that will impact your work in this class, please schedule an appointment
with the course coordinator, Dr. Geahlen, as soon as possible to discuss your needs.