Download Texto - OG

Breast Cancer
Shannan McQuade & Ashley
Haman
History of Breast Cancer
• Ancient Egyptians discovered Breast
Cancer
– Over 3,500 years ago
• Hippocrates discovered it
• Named the disease karkinos
– Greek name for “crab”
History Cont.
• Henri Le Dran
• In 1957 suggested that surgical removal of
the tumors could help treat it
• Infected lymph nodes of the armpit must
be removed
• 1900 & 2000
• William Halsted developed radical
mastectomy that removed breast and
auxiliary node
What happens?
• There are no known
symptoms (early breast
cancer)
• Later symptoms
(women):
– Lump on breast or
near armpit
• Hard, uneven
edges
• Usually doesn’t hurt
– Change in size, shape,
or feel of breast/nipple
– Fluid from nipple
• Symptoms in men:
– Breast lump
– Breast pain and
tenderness
• Advanced Symptoms:
–
–
–
–
Bone pain
Breast pain
Skin ulcers
Swelling of armpit by
breast
– Weight loss
Treatment Factors
• Discovery:
–
–
–
–
–
–
Breast MRI
Breast ultrasound
Breast biopsy
CT scan
Mammography
PET Scan
• Type and stage
• Sensitive to
hormones
• Over produces
HER2/neu
– Transmembrane
protein
Treatment
• Local
– Only area of disease
• Radiation and surgery
• Systemic
– Affects whole body
• chemotherapy
• Targeted therapy
(Biologic therapy)
– Anti-cancer drug target
certain cell
• Hormone therapy
– Block hormones that
fuel cancer growth
• Lumpectomy (remove
• Drug tamoxifen
lump)
• Aromatize inhibitors
• Mastectomy (removes
• Chemotherapy
all of breast)
• Radiation therapy
How is Breast Cancer passed on?
• Only 10% of Breast Cancer is inherited.
– Caused by mutated gene
– The gene is usually passed down from mother
(sometimes father)
• Only know of two genes that cause breast cancer:
– BRCA 1 & BRCA 2
• Other causes include:
– Late pregnancy
– Age:
• ¼ affect women under 50
• ½ affect women between the ages of 50-69
• ¼ affect women 70 years or older
Interesting Facts
•
•
•
•
•
•
•
Kathy Bates
Sheryl Crow
Ann Romney
Richard Roundtree
Judy Bloom
1/8 women will have breast cancer
226,000 women in the US will be diagnosed this
year
• 2,200 men in the US will be diagnosed
Works Cited
• American Institute for Cancer Research.
American Institute for Cancer Research. 12 Feb.
2013. Web. 25 Feb. 2013.
• Mandal, Ananya Dr. MD. “History of Breast
Cancer.” News Medical. n.p. Web. 25 Feb. 2013.
• Donnelly, Kaitlin. “17 Celbs Who Lived with
Breast Cancer.” Prevention. Prevention. Sep.
2012. Web. 25 Feb. 2013.
• Pub Med Health. U.S. National Library of
Medicine. 18 Sep. 2012. Web. 25 Feb. 2013.