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New Treatments Summary New drug treatments Chronotherapy Lung cancer vaccine New drug treatments - Royal Marsden Hospital (London) - Specific mutations - Sophie (11y/o) → success Chronotherapy - Biological clock - Circadian rhythms - Signs + symptoms change → Chronotherapy - Treatments at most optimal time Chronotherapy - Inconvenients: - Best time = night (often) Mechanisms not well known - P53 protein: - tumour suppressor helps prevent mutation - Personalised treatment Lung cancer vaccine Introduction - Center of Molecular Immunology 1st lung cancer vaccine Cimavax Not a cure: survival of patient - helps immune system - therapeutic vaccine - Advantages - Cheap to produce + store - Few side effects nausea - chills - fever - How does it work ? Cancer stimulates production EGF Stimulates growth of cells Tumors multiply + grow uncontrollably EGF : epidermal growth factor → body creates antibodies Research - Chemotherapy + ½ vaccine - Trials showed: - More antibodies Lived longer Reduces cancer symptoms This vaccine could be used for other types of cancer Conclusion - A lot of new treatments - More and more effective - Cancer has to be found early - However, treatments more effective on some people than on others