Download African horse sickness

Emerging and Re-emerging Diseases
Dr Lonnie King
Centre for Emerging and Reemerging Zoonotic Diseases
Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia USA
Tel.: (1-404) 639.0695, Fax: (1-404) 639.7090
[email protected]
Summary of activities specifically related to the mandate of
OIE Collaborating Centres
1.
Activities as a centre of research, expertise, standardisation and dissemination of techniques
within the remit of the mandate given by the OIE

World Rabies Day September 8, 2007. Hosted by CDC in Atlanta, Georgia, USA. This was the premier
International format for exchange and dissemination of information on rabies. OIE and WHO, and PAHO were
co-sponsors of this extremely successful event. www.worldrabiesday.org

CDC International Symposium of Biosafety (held every 2-yrs/ see: www.cdc.gov/of/ohs)
–
9th Symposium: Current Challenges in Animal Biosafety and Biosecurity (Jan-06). Three day event with
over 650 participates representing 11-countries.
–
10th Symposium: Protecting Workers in Clinical Laboratories, Researchers, Animal Care and Public
Health Communities (Feb-08).
 Occupational Health Care and Medical Surveillance for Laboratory Workers and Animal Care Staff (Feb-07).
Two day symposium with over 100 participants, consisting of physicians, nurses, and other medical providers,
that support human and animal research programs.
2.
Proposal or development of any procedure that will facilitate harmonisation of international
regulations applicable to the surveillance and control of animal diseases, food safety and animal
welfare
 CDC participated in the development of the CEN- International Biosafety/Biorisk Laboratory Management
Standard (Ref: WHO Laboratory Biosafety Manual). Workshops were held in Brussels with global
participation from both human, animal research and biosafety communities.
 Published: 5th edition, CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL),
electronic version-2007, hardcopy print early-2008
–
Includes new USDA chapter on safety recommendations for working with animal-agriculture pathogens.
 Published: 3rd edition, CDC/NIH Primary Containment for Biohazards: Selection, Installation, and Use of
Biological Safety Cabinets, electronic version-2007, hardcopy print early-2008
–
Contains latest guidance for human and animal research laboratories that utilize biosafety cabinets as
primary containment barrier.
 Produced: Principles of Biosecurity-CD (web-based) for public distribution. Material explains:
–
Concepts of Laboratory Biosecurity (Protecting biological agents)
–
How to Perform a Biosecurity Risk Assessment
–
Components of a Biosecurity Plan
 Developing: CDC/USDA Principles of Biosafety in BSL-2 Laboratories – Classroom training program/9modules (production mid-way). Objectives: Ensure standardized interpretation and implementation of
biosafety concepts within national response laboratories.
Annual reports of OIE Reference Laboratories and Collaborating Centres, 2007
1
Emerging and Re-Emerging Diseases
 Developing: CDC/NLTN Packaging and Transport of Infectious Substances (product almost complete)
 Developing: CDC/LRN Video: Operation of the Biosafety Cabinets (product under development)
 Developing: CDC/LRN Video: Virtual Tour of BSL 1-3 Laboratories (product under development)
 Produced: CDC Select Agent Program Video: Biosafety Level-3 Inspection Process (per BMBL)
 Produced: Select Agent guidance documents and training videos available on the national select agent website
(www.selectagents.gov).
3.
Placement of expert consultants at the disposal of the OIE
 All CDC Subject Matter Experts (SMEs) regularly serve as technical consultants for multiple countries and
entities. Many times our expertise as seen from the above comes in the form of formal and impromptu training.
 CDC participated in an OIE ad hoc committee on vector-borne disease and climate change
 CDC participated in a number of zonotic disease outbreaks providing specific expertise in these diseases:
–
RVF outbreak East Africa (Kenya and Tanzania)
–
EHF in Congo and Uganda;
–
Marburg in Uganda
–
Brucellosis and Q-fever in Bosnia
Other activities related to the mandate
of OIE Collaborating Centres
4.
Provision of scientific and technical training, within the remit of the mandate given by the OIE, to
personnel from Member Countries of the OIE
Multiple trainings have been given on Avian Influenza to many member countries. A list will gladly be provided if
requested.
 CDC provides support to Ministries of Agriculture and safety colleagues the following counties. Support
included biosafety/biosecurity, lab site visits, consultation, lectures and training, lab construction and design
reviews, etc.
Canada
Brazil
Panama
Kenya
Mexico
Thailand
Botswana
Guatemala
China
 Funded and supported the following WHO/OIE Laboratory Safety Projects:
–
WHO workshop - Ensuring effective transport of infectious substances - Geneva 2007 Note-OIE & FAO
were critical participants
–
WHO PAHO Regional MoH/MoAg Biosafety/Biosecurity Awareness and Advocacy workshops
– Guatemala 2006 (11-Countries)
–
WHO AFRO (English) Regional MoH/MoAg Biosafety/Biosecurity Awareness and Advocacy workshop
– Kenya 2007 (21-Countries)
–
WHO AFRO (French) Regional MoH/MoAg Biosafety/Biosecurity Awareness and Advocacy workshop
– Kenya 2008 (22-countries)
–
WHO-Biosafety/Biorisk Management for Laboratories Holding Flu Virus – Laboratory Assessment
Standard and Inspections (under development)
 CDC presented training on laboratory safety, security, occupational health and worker protection at over two
dozen public health, animal/agriculture research, and scientific venues in the past year including:
–
USDA National Animal Disease Center - Safety Forum
2
Annual reports of OIE Reference Laboratories and Collaborating Centres, 2007
Emerging and Re-Emerging Diseases
–
–
–
–
–
–
–
–
–
–
–
5.
American Association of Laboratory Animal Science
International Veterinary Biosafety Association
American Society of Microbiology,
American Biological Safety Association,
Canadian Biological Safety Association
Association of Public Health Laboratories
National Laboratory Training Network, of State Laboratories
American College of Occupational and Environmental Medicine,
National Environmental Health Association,
American Industrial Hygiene Association
Etc.
Organisation of scientific meetings on behalf of the OIE
 International Conference on Emerging Infectious Diseases - CDC is planning the International Conference on
Emerging Infectious Diseases 2008 to be held in Atlanta Georgia USA on March 16-19 2008. Zoonotic disease
has it’s own session
 OIE is a member of the Scientific Planning Committee for ICEID 2008; Dr Alex Thiermann is OIE’s
representative to this committee.
 Chaired a symposium on "Forecasting human risk for of hantavirus disease" at 27th annual International
Symposium on Forecasting, New York, NY, 24-27 June, 2007.
 Organized and chaired session on "Ecology and virus-host interaction" at the VII International Conference on
HFRS, HPS and Hantaviruses, in Buenos Aires, 13-15 June, 2007.
 Organized and chaired a special symposium entitled "Current worldwide status of ecological studies of
hantavirus host ecology" at that same conference in Buenos Aires.
6.
Coordination of scientific and technical studies in collaboration with other laboratories or
organisations
 CDC has a project in collaboration with the Thailand government including the Ministry of Health and
Agriculture, to determine best practices to remediate a zoonotic disease outbreak. This project will have a
meeting with members of regional and local Thai officials as well as members of OIE, FAO, WHO and CDC.
Information gained from this best practices meeting will then be made available to any other country that
wishes to receive it. If future funding allows, trainings will be developed and done by both Thai and other
international partners.
 CDC participates in and provides some funding for the Global Avian Influenza Network for Surveillance
www.gains.org. This system is an international system open to any country to determine the prevalence of AI
in their country. It is operated by the Wildlife Conservation Society.
 CDC has 5 cooperative agreements concentrating on the animal human interface particularly regarding avian
influenza. These cooperative agreements are located in several universities and include international partners.
These cooperative agreements have as their focus, to better understand the science of the animal human
interface including risk factors for disease, cellular changes and adaptations as likely causes of disease.
 Our Centre is engaged in an ongoing collaboration with the Centre for Animal Disease Surveillance Systems
and Risk Analysis (Centers for Epidemiology and Animal HealthUSDA-APHIS-VS-CEAH, Fort Collins,
Colorado USA). Staff from both Centres participate in the Interagency Working Group for Zoonotic Disease
Surveillance whose current focus is on improved coordination of surveillance for foodborne diseases and avian
influenza.
 CDC/USDA/OIE Project: Sustainable laboratory biosafety/biosecurity support to Ministries of Agriculture
(MoAg), primarily BSL-2 Labs.
Annual reports of OIE Reference Laboratories and Collaborating Centres, 2007
3
Emerging and Re-Emerging Diseases
Goal: Explore mechanisms to provide laboratory biosafety/biosecurity support to Ministries of Agriculture
(MoAg), primarily BSL-2 Labs. Note - CDC is receiving increased numbers of biosafety requests from
MoAg's.
Objectives:
(1) Initiate discussion with USDA & OIE;
(2) Request their support in addressing this issue; and
(3) Provide funding to support an OIE stakeholders meeting to discuss support options (to include a review of
WHO's model for global Biosafety Collaborating Centres). Projected meeting date: Spring-Summer 2008.
 WHO Global Salm-Surv
WHO Global Salm-Surv (WHO GSS) is a network of institutions and individuals committed to enhancing the
capacity of national ministries of health and agriculture, as well as reference laboratories, to detect, to respond
and to prevent foodborne and other infectious, enteric diseases. WHO Global Salm-Surv promotes integrated
laboratory-based surveillance and fosters inter-sectoral collaboration among human health, veterinary, and
food-related disciplines through training courses and other activities globally.

In 2007, WHO GSS conducted nine regional and national training courses.
 The following courses were held: an Advanced Workshop for Southeast Asia (Thailand), a Level I
Microbiology Training for the Indian Ocean Islands (Madagascar), a Level III MicrobiologyEpidemiology Training for Central America (Guatemala), an Advanced Workshop for the Middle East
(Egypt), an Advanced Workshop for the Caribbean (Trinidad), an Advanced Workshop for Russia and
the Commonwealth of Independent States (Russia-St. Petersburg), a Level I Microbiology Training
for Anglophone Central and Eastern Africa (Kenya), a Level II Microbiology-Epidemiology Training
for Brazil, and an Advanced Workshop for China.
 Approximately 400 microbiologists and epidemiologists globally were trained at these courses.
7.
Publication and dissemination of any information within the remit of the mandate given by the
OIE that may be useful to Member Countries of the OIE
In the interest of staying as close as possible with the stated guidelines of a 2 – 3 page report, manuscripts have
been left off. We would be glad to provide a full listing of articles that have been published in the area of
zoonoses. This list is greater than 45 articles.
_______________
4
Annual reports of OIE Reference Laboratories and Collaborating Centres, 2007